Recombinant Mouse Actin-related protein 2/3 complex subunit 3(Arpc3)

Code CSB-YP867558MO
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Source Yeast
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Code CSB-EP867558MO
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Source E.coli
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Code CSB-EP867558MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP867558MO
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Source Baculovirus
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Code CSB-MP867558MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Arpc3
Uniprot No. Q9JM76
Alternative Names Arpc3Actin-related protein 2/3 complex subunit 3; Arp2/3 complex 21 kDa subunit; p21-ARC
Species Mus musculus (Mouse)
Expression Region 2-178
Target Protein Sequence PAYHSSLMD PDTKLIGNMA LLPLRSQFKG PAPRETKDTD IVDEAIYYFK ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI TNFPIPGEPG FPLNAIYAKP ASKQEDEMMR AYLQQLRQET GLRLCEKVFD PQSDKPSKWW TCFVKRQFMN KSLSGPGQ
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Gene References into Functions
  1. This study provided the first evidence that the Arp2/3 complex, a key actin nucleator, is involved in distinct stages of spine formation and is required for synapse unsilencing. PMID: 27629719
  2. In the absence of ArpC3, enterocytes had defects in the organization of the endolysosomal system: transcytosis of IgG was disrupted, lipid absorption was perturbed, and neonatal mice died within days of birth. PMID: 25833710
  3. GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch. PMID: 23727094
  4. Together with the observation that Gadkin-mediated inhibition of cell spreading requires its binding to ARP2/3, these data indicate that Gadkin is a negative regulator of ARP2/3 function present on intracellular membranes PMID: 22689987
  5. results demonstrate a critical role for the Arp2/3 complex in the assembly of lamellipodia-based leading edges and directional cell motility PMID: 22492726
  6. that targeting of Arpc3 by miR-29a/b fine tunes structural plasticity by regulating actin network branching in mature and developing spines PMID: 21930776
  7. These data indicate the importance of Arpc3 in the Arp2/3 complex for trophoblast outgrowth and suggest that Arpc3 may be indispensable for implantation. PMID: 16880528

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Subcellular Location Cytoplasm, cytoskeleton, Cell projection
Protein Families ARPC3 family
Database Links

KEGG: mmu:56378

STRING: 10090.ENSMUSP00000099584

UniGene: Mm.275942

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