Recombinant Mouse Axin-2(Axin2) ,partial

Code CSB-YP528352MO
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Source Yeast
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Code CSB-EP528352MO
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Source E.coli
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Code CSB-EP528352MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP528352MO
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Source Baculovirus
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Code CSB-MP528352MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Axin2
Uniprot No. O88566
Alternative Names Axin2; Axin-2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).
Gene References into Functions
  1. Study provides evidence that Axin2-expressing cells execute regeneration after skeletal injury. PMID: 27853243
  2. identify Rap1b acting downstream of Axin2 as a signaling interrogator for FGF and BMP. Genetic analysis reveals that Rap1b is essential for development of craniofacial and body skeletons. Axin2 regulates Rap1b through modulation of canonical BMP signaling. PMID: 28520221
  3. increased mesenchymal Wnt signaling inhibits the sequential formation of teeth, and suggest that Axin2/Runx2 antagonistic interactions modulate the level of mesenchymal Wnt/beta-catenin signaling, underlying the contrasting dental phenotypes caused by human AXIN2 and RUNX2 mutations PMID: 29437780
  4. we found that ESC-derived tissues at day 7 grown in Glasgow Minimum Expression Media (GMEM) containing knockout serum replacement (KSR) exhibited higher levels of expression of axin2, a Wnt target gene, than those grown in chemically defined medium PMID: 27151576
  5. Barx2 and Pax7 regulate the canonical Wnt target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt signals. PMID: 27144473
  6. Axin2 limits Wnt/beta-catenin signalling after birth and allows proper heart valve maturation. Moreover, dysregulation of Wnt/beta-catenin signalling resulting from loss of Axin2 leads to progressive myxomatous valve disease. PMID: 28069701
  7. Wnt/beta-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers PMID: 27578179
  8. Our results reveal a critical role for Axin2 during ocular development, likely by restricting the activity of the Wnt/beta-catenin pathway. PMID: 27701636
  9. The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis PMID: 26929341
  10. Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/beta-catenin signaling. PMID: 26903625
  11. Axin2-expressing prostatic cells express epithelial cell markers and are able to expand cell lineage during prostatic development and maturation. PMID: 26220362
  12. These data demonstrate a dominant role for Runx2 in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation. PMID: 24973690
  13. implants lacking primary stability undergo osseointegration, provided Wnt signalling is amplified. Fibrous encapsulation can be prevented and osseointegration assured if Wnt signalling is elevated at the time of implant placement. PMID: 24164629
  14. Axin2(-/-) PF-sutures lack physiological endochondral ossification PMID: 23936395
  15. Axin2(+) cells can give rise to spatially and functionally restricted populations of adult neural stem cells in the subventricular zone. PMID: 23589866
  16. Axin2-positive tympanic border cells are Wnt responsive and can act as precursors to sensory epithelial cells in the postnatal cochlea. PMID: 23444352
  17. Runx2 protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice PMID: 23300083
  18. Data show that expression of Brachyury targets Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos. PMID: 22479388
  19. Lgr5 and Axin2 differential expression among cell populations highlights the dynamic but complex distribution of Wnt-activated cells in and around the embryonic and postnatal cochlea. PMID: 21472479
  20. although increased stability of Axin2 leads to a loss of canonical Wnt signaling in most tissues, stabilized Axin2 enhances Wnt pathway activity in a specific progenitor population in the late primitive streak. PMID: 21555575
  21. Results suggest a key regulatory pathway of Axin2/beta-catenin/cyclin D1 in development of the suture mesenchyme. PMID: 21108844
  22. Data show that knockout of gene Axin2, a negative regulator of the WNT-beta-catenin pathway, and gene FGFR1 induced ectopic chondrogenesis, leading to abnormal suture morphogenesis and fusion. PMID: 20501936
  23. Expression of Axin2 indicates a role for canonical Wnt signaling in development of the crown and root during pre- and postnatal tooth development. PMID: 19653310
  24. Disruption of Axin2 induces malformations of skull structures resembling craniosynostosis in humans; these are mediated through activation of beta-catenin signaling, suggesting a novel role for the Wnt pathway in skull morphogenesis. PMID: 15790973
  25. Axin 2 was shown to be functionally equivalent to axin. PMID: 15899843
  26. The oscillation of Dact1 occurs in phase with the Wnt signaling component Axin2, and out of phase with the Notch signaling component Lfng. PMID: 17013874
  27. Axin2 negatively regulates both expansion of osteoprogenitors and maturation of osteoblasts through its modulation on Wnt/beta-catenin signaling PMID: 17113065
  28. Axin2 expressing cells that co-express Sca-1 are present in all prostate lobes suggesting that progenitor cells reside within the Wnt active population. PMID: 18563716
  29. Axin2 is a negative regulator in bone remodeling in adult mice and regulates psteoblast differentiation through the beta-catenin-BMP2/4 signaling pathway in osteoblasts. PMID: 19737815

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Subcellular Location Cytoplasm
Database Links

KEGG: mmu:12006

STRING: 10090.ENSMUSP00000051331

UniGene: Mm.71710

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