Recombinant Mouse Bcl-2-binding component 3 (Bbc3)

1. Expression from a luciferase reporter construct containing the 2 kb fragment of the promoter region of bcl-2-binding component 3 (PUMA) is enhanced by activation of the muscle regulatory transcription factor MyoD in both myoblasts and fibroblasts and diminishes by silencing of MyoD in myoblasts. E-Box Sequences at position - 857 of PUMA is the binding site for MyoD. PMID: 28918507
2. Proapoptotic proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL. PMID: 28682312
3. The mitochondrial apoptotic pathway, activated by BH3-only proteins, BIM and PUMA, is essential for endoplasmic reticulum stress-induced cell death; DR5 as well as caspase-8 are not required for this process. PMID: 28409774
4. Mir143-BBC3 has roles in microglial survival in the context of drug abuse PMID: 27464000
5. In the mouse model of silicosis, Bbc3 knockout mice clearly exhibited decreased levels of autophagy and fibrosis progression. These results suggest that downregulation of BBC3 expression may become a novel therapeutic strategy for the treatment of silicosis. PMID: 28277537
6. This study has demonstrated that methamphetamine-mediated pericytes migration involves PUMA up-regulation. PMID: 28408317
7. Data show that Emu-Myc mice lacking both p21 and PUMA developed lymphoma at a rate considerably longer latency than Emu-Myc;p53(+/-)mice. PMID: 26640149
8. Our data show a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic host cell death during Listeria infection. PMID: 27064265
9. Overexpression of miR-29 or miR-24 is sufficient to inhibit the induction of Bim and Puma in young sympathetic neurons. PMID: 27797453
10. loss of PUMA had no impact on the loss of platelets caused by loss of BCL-XL. It therefore remains to be established whether other BH3-only proteins play a critical role in induction of apoptosis in platelets or whether their death is controlled solely by the interactions between BCL-XL with BAK and BAX. PMID: 27221652
11. PUMA is dispensable for glucose homeostasis in lean and obese mice, but it can affect leptin levels and food intake during obesity. PMID: 27033313
12. MYSM1 is a critical negative regulator of p53 transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cel function. PMID: 26768662
13. Therapeutic response to non-genotoxic activation of p53 by Nutlin3a is driven by PUMA-mediated apoptosis in lymphoma cells. PMID: 26904937
14. Bim and Puma overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles. PMID: 26179069
15. Beta-arrestin 2 promotes inflammation-induced intestinal epithelial apoptosis through endoplasmic reticulum stress/PUMA in colitis. PMID: 25354317
16. Puma is the major mediator of virus-induced Bax/Bak activation and mitochondrial membrane permeabilization induction. PMID: 26030884
17. Oxidative stress increases PUMA expression regulated by FoxO1 in follicular granulosa cells. PMID: 25425107
18. Results indicate that PUMA is involved in the apoptosis of cerebral astrocytes upon ischemia/reperfusion injury PMID: 25451294
19. by preventing the consumption of IL-15, Bim limits the role of Noxa and Puma in causing the death of effector cells with less memory potential. PMID: 25124553
20. These results demonstrate that antagonism between PUMA and MCL-1 constitutes the major axis of control of hematopoietic stem cell survival. PMID: 25847014
21. caspase-9 mediates Puma activation to determine the threshold for overcoming chemoresistance in cancer cells. PMID: 25356864
22. Stable knockdown of Bim or PUMA expression prevented cell toxicity induced by loss of Keap1. PMID: 24769730
23. Loss of Bbc3 results in prolonged fertility. PMID: 24859845
24. c-Jun transactivates Puma gene expression to promote osteoarthritis. PMID: 24566851
25. Data demonstrate that high concentrations of glucose induce endoplasmic reticulum and oxidative stress, which causes pancreatic beta cell death mediated by Bim and Puma. PMID: 24625983
26. PUMA mediates endoplasmic reticulum stress-induced mucosal epithelial apoptosis through the mitochondrial apoptotic pathway in portal hypertensive gastropathy. PMID: 24625987
27. Pdx1 gene expression was knocked down in mouse MIN6 insulinoma cells resulting in apoptotic cell death that was found to be associated with increased expression of BH3-only molecules Bim and Puma. PMID: 24658302
28. Slug promotes survival during metastasis through suppression of Puma-mediated apoptosis. PMID: 24830722
29. The data if this study demonstrated that Puma is pivotal for oligodendroglial cell death induced by different cell death stimuli. PMID: 23922240
30. these results provide strong evidence that Puma, like Bim, Noxa, and tBid, is able to act as a direct Bak activator. PMID: 24265320
31. PUMA deficiency leads to a better survival rate associated with reduced DNA damage and fewer chromosomal aberrations in induced pluripotent stem cells, whereas loss of p21 or p53 results in an opposite outcome. PMID: 23873265
32. Induction of senescence was only impaired in cells from the p21-/- puma-/- noxa-/- mice but abrogated in cells from the p53-/- mice. PMID: 23665218
33. Microglia-derived TNF-alpha induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma. PMID: 23492769
34. amino acid (AA) starvation elevates PUMA, an effect that is blocked by extracellular acidity. PMID: 23261451
35. PUMA protein regulates autophagy, Erk activation, and intracellular calcium level. PMID: 23122957
36. a novel and critical link between the AKT, GSK3beta and JNK kinases and the regulation of Puma induction PMID: 23056511
37. Transforming growth factor-beta directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas PMID: 23243310
38. Our study demonstrates a role for PUMA in the death of retinal ganglion cells. PMID: 23365256
39. Data show that PUMA and NOXA are critical for DNA damage-induced, TAp63-mediated primordial follicle oocyte apoptosis. PMID: 23000175
40. TLR4 is expressed on intestinal stem cells where it regulates their proliferation and apoptosis through activation of PUMA. PMID: 22955282
41. Data show that Puma cooperates with Bim to impose a thymic-deletion checkpoint to peripheral self-antigens and cement the notion that defects in apoptosis alone are sufficient to cause autoimmune disease. PMID: 22960223
42. Context-dependent enhancement of induced pluripotent stem cell reprogramming by silencing Puma PMID: 22311782
43. identify Puma and Bim as key mediators of DNA damage-induced bone marrow failure and provide mechanistic insight into how BH3-only proteins trigger cell death. PMID: 22015606
44. Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. PMID: 21997190
45. Deletion of Puma improves stem- and progenitor-cell function. PMID: 22138576
46. Regulatory T cells can suppress the proliferation of Bim-deficient/Puma-deficient conventional T cells in a manner largely indistinguishable from wild-type conventional T cells. PMID: 21949016
47. in response to DNA-damage, Noxa efficiently induces apoptosis by "release" of Puma from Mcl-1. PMID: 21945433
48. Puma is a major regulator of memory B lymphocyte survival and therefore a key molecule in the control of the immune response. PMID: 21868573
49. In mice and humans, colon inflammation induces apoptosis of intestinal epithelial cells via p53-dependent and - independent mechanisms; PUMA also activates an intrinsic apoptosis pathway associated with colitis. PMID: 21699775
50. Bim and Puma expression is induced by endogenous ROS in a SIRT1-dependent manner. PMID: 21083429

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KEGG: mmu:170770

STRING: 10090.ENSMUSP00000002152

UniGene: Mm.7660