Recombinant Mouse Bcl-2-like protein 11(Bcl2l11)

Code CSB-YP002615MO
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Source Yeast
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Code CSB-EP002615MO
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Source E.coli
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Code CSB-EP002615MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002615MO
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Source Baculovirus
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Code CSB-MP002615MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Bcl2l11
Uniprot No. O54918
Alternative Names Bcl2l11; BimBcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death
Species Mus musculus (Mouse)
Expression Region 1-196
Target Protein Sequence MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QGNPDGEGDR CPHGSPQGPL APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS PAPMSCDKST QTPSPPCQAF NHYLSAMASI RQSQEEPEDL RPEIRIAQEL RRIGDEFNET YTRRVFANDY REAEDHPQMV ILQLLRFIFR LVWRRH
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Induces apoptosis and anoikis. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent.
Gene References into Functions
  1. data suggest a role for BIM in regulating mitochondrial bioenergetics and metabolism and support the idea that regulation of metabolism and cell death are connected. PMID: 29053141
  2. the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thymocyte survival. PMID: 29038463
  3. Increased expression of miR-214 suppresses PTEN expression and represses Bim1 expression. PMID: 27894079
  4. Study provides evidence that Bim transcription which is dependent of FOXO3A protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in Kupffer cells. PMID: 28427239
  5. The mitochondrial apoptotic pathway, activated by BH3-only proteins, BIM and PUMA, is essential for endoplasmic reticulum stress-induced cell death; DR5 as well as caspase-8 are not required for this process. PMID: 28409774
  6. Bcl2l11 as the direct target of miR-9 and manipulation of miR-9 induces the corresponding changing of Bcl2l11 protein level. PMID: 26660116
  7. these data suggest that the Bim may be a novel therapeutic target in the treatment of systemic lupus erythematosus. PMID: 29114065
  8. Data show that the induction of BIM in the MYC- and RAS-driven leukemia is mediated by the downregulation of miR-17-92, and suggest that induction of BIM-mediated apoptosis may be a therapeutic approach for acute lymphoblastic leukemia (ALL). PMID: 27095570
  9. Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction. PMID: 27195679
  10. understanding the cell autonomous role Bim plays in the retinal vascular homeostasis will give us new insight into how to modulate pathological retinal neovascularization and vessel regression to preserve vision PMID: 28552963
  11. The central role of Bim-dependent apoptosis in Buruli Ulcer pathogenesis PMID: 28294596
  12. we found a temporal and tissue-specific role for Bim in limiting thymic agonist selection of CD8alphaalpha precursors and their TCRbeta repertoire, but not in the maintenance of CD8alphaalpha intraepithelial lymphocytes in the intestine. PMID: 27852740
  13. loss of the BH3-only protein BIM accelerated lymphoma development in p53-deficient mice. This process was negated by concomitant loss of RAG1/2-mediated antigen receptor gene rearrangement. PMID: 27621418
  14. Overexpression of miR-29 or miR-24 is sufficient to inhibit the induction of Bim and Puma in young sympathetic neurons. PMID: 27797453
  15. the activation of ERK5-AKT-FoxO3a signaling pathways by fluid shear stress resulted in a decreased expression of FasL and Bim and an inhibition of caspase-3 activation, which exerts a protective effect that prevents osteoblasts from apoptosis. PMID: 27060196
  16. long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan PMID: 27525555
  17. Results indicate that upregulation of miR-124 could regulate apoptosis and impaired autophagy process in the MPTP model of Parkinson's disease, thus reducing the loss of dopaminergic neurons PMID: 25976060
  18. Rapid activation of AMPK was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 activation but not increased intracellular AMP levels or CaMKKbeta activation. PMID: 26856538
  19. Consistent with a contribution of BCL2 family proteins to the second wave of cell death during involution, loss of Bim reduced the number of apoptotic cells in this irreversible phase PMID: 26045049
  20. The current study demonstrated that the BH3-only protein, Bim, might regulate a subset of inflammatory cells in the gastric mucosa during H. pylori-mediated gastritis. PMID: 26197709
  21. Bcl2 interacting mediator of cell death (Bim) and Bcl2 modifying factor (Bmf), mediate apoptosis in the context of TACI-Ig overexpression that effectively neutralizes BAFF as well as APRIL. PMID: 25698446
  22. these results indicate that 1alpha,25(OH)2D3 and TX 527 trigger apoptosis by Bim protein increase which turns into the activation of caspase-3 in SVEC and vGPCR cells PMID: 26254608
  23. miR-155 regulates the delicate balance between PAK1-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function. PMID: 26121028
  24. The findings reveal an essential role for TRIM33 in preventing apoptosis in B lymphoblastic leukemia by interfering with enhancer-mediated Bim activation. PMID: 25919951
  25. BIM deficiency prevents diabetes in NOD mice by diverting thymocytes to Treg cells via reduced thymic deletion. PMID: 25948683
  26. with age, enhanced ICOS expression on eTregs likely limits Bim expression via activation of the PI3K/Akt/FOXO pathway, promoting eTreg survival. PMID: 26109645
  27. SNAI2-driven BIM-induced apoptosis may temper metastasis by governing the survival of disseminating breast tumor cells. PMID: 25263453
  28. Hsp27 binding to the 3'UTR of Bim mRNA prevents neuronal death during oxidative stress-induced injury. PMID: 25187648
  29. Dicer ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth. PMID: 24500693
  30. by preventing the consumption of IL-15, Bim limits the role of Noxa and Puma in causing the death of effector cells with less memory potential. PMID: 25124553
  31. Loss of BIM in the adult mouse rapidly results in the hematopoietic phenotypes. PMID: 25299771
  32. Cafestol overcomes ABT-737 resistance in Mcl-1-overexpressed renal carcinoma Caki cells through downregulation of Mcl-1 expression and upregulation of Bim expression. PMID: 25375379
  33. Data indicate that combined deficiency in Bcl2l11 protein Bim and nuclear hormone receptor Nur77 impaired clonal deletion efficiency and significantly increased positive selection efficiency. PMID: 25687757
  34. loss of even a single Bim allele sufficed to substantially accelerate lymphomagenesis, and only loss of both but not loss of a single allele of Bclx could attenuate this acceleration. PMID: 24858047
  35. miR-148a controls cell survival by regulating Bim expression. PMID: 25486906
  36. Bim is a master regulator of apoptosis induced by M. tuberculosis. PMID: 25032866
  37. The mitochondrial apoptotic pathway activated via Bim is critically involved in apoptosis induced by mouse granzyme B. PMID: 25605735
  38. Reduced miR-9 and miR-181a expression down-regulates Bim concentration and promotes survival of osteoclasts from fractured tibias. PMID: 24966929
  39. E4BP4 plays a crucial role in glucocorticoid -evoked apoptosis of osteoblasts by enabling induction of Bim PMID: 24658772
  40. These results suggest that Bim plays an important role in mediating the increase in beta-cell apoptosis and the reduction in beta-cell mass that occurs in IRS2-deficient diabetes. PMID: 24760140
  41. Pro-apoptotic Bim and anti-apoptotic Mcl-1. PMID: 24825007
  42. Data demonstrate that high concentrations of glucose induce endoplasmic reticulum and oxidative stress, which causes pancreatic beta cell death mediated by Bim and Puma. PMID: 24625983
  43. three miRNA families, miR-20, miR-92, and miR-302, control the mitochondrial apoptotic machinery by fine-tuning the levels of expression of the proapoptotic protein BIM PMID: 25184675
  44. Pdx1 gene expression was knocked down in mouse MIN6 insulinoma cells resulting in apoptotic cell death that was found to be associated with increased expression of BH3-only molecules Bim and Puma. PMID: 24658302
  45. Bim-mediated apoptosis drives selective contraction of effector NK cells to generate a pool of mature, MCMV-specific memory cells. PMID: 24958849
  46. STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose medium. PMID: 24407239
  47. IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints. PMID: 24835393
  48. Bim controls both T-cell activation and death in response to alloantigen stimulation. PMID: 24700126
  49. Bim and Bmf act in concert to prevent autoimmunity and malignant disease PMID: 24632712
  50. Deletion of Bim in B cells, in the context of cyclin D1 overexpression, disrupts a critical control point in lymphoid maturation and predisposes to the development of mantle cell lymphoma. PMID: 24352880

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Subcellular Location Membrane; Peripheral membrane protein. Mitochondrion. Note=Associated with intracytoplasmic membranes.
Protein Families Bcl-2 family
Tissue Specificity Expressed in a number of B- and T-lymphoid cell lines.
Database Links

KEGG: mmu:12125

STRING: 10090.ENSMUSP00000105970

UniGene: Mm.141083

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