Recombinant Mouse Bcl-2-related ovarian killer protein(Bok)

Code CSB-YP002773MO
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Source Yeast
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Code CSB-EP002773MO
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Source E.coli
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Code CSB-EP002773MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002773MO
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Source Baculovirus
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Code CSB-MP002773MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Bok
Uniprot No. O35425
Alternative Names Bok; MtdBcl-2-related ovarian killer protein; Apoptosis activator Mtd; Protein matador
Species Mus musculus (Mouse)
Expression Region 1-213
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

(From Uniprot)
Apoptosis regulator that functions through different apoptotic signaling pathways
Gene References into Functions
  1. we show that BOK(C) can permeabilize liposomes, and cooperate with cBID, but its role in directly mediating mitochondrial permeabilization is unclear and may underlie a yet to be determined negative regulation. PMID: 28064468
  2. Bok controls neuronal Ca(2+) homeostasis and bioenergetics in seizure-induced neuronal injury. PMID: 27098698
  3. Study reports that BCL-2 ovarian killer (BOK) is a bona fide yet unconventional effector of mitochondrial outer membrane permeabilization that can trigger apoptosis in the absence of both BAX and BAK. PMID: 26949185
  4. findings support a selective and distinguishing role for BOK in regulating the apoptotic response to ER stress, revealing--to our knowledge--the first bona fide apoptotic defect linked to Bok deletion PMID: 26015568
  5. BOK-deficient mice have no readily discernible abnormalities, and its function therefore remains unresolved. PMID: 23744350
  6. Bok may govern IP3R cleavage and activity during apoptosis. PMID: 23884412
  7. two proapoptotic Bcl-2 family members Bok and Noxa/Pmaip are directly transcriptionally induced by activated MAL and upon activation of the actin-MAL-SRF pathway PMID: 22185759
  8. Bok protein have a role that largely overlaps with that of other members of the Bcl-2 family, or may have a function restricted to specific stress stimuli and/or tissues. PMID: 22281706
  9. Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 family PMID: 16772296

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Subcellular Location Mitochondrion membrane, Single-pass membrane protein, Endoplasmic reticulum membrane, Single-pass membrane protein, Mitochondrion inner membrane, Cytoplasm, Nucleus, Mitochondrion, Endoplasmic reticulum, Mitochondrion outer membrane, Early endosome membrane, Recycling endosome membrane, Nucleus outer membrane, Golgi apparatus, cis-Golgi network membrane, Golgi apparatus, trans-Golgi network membrane, Membrane
Protein Families Bcl-2 family
Tissue Specificity Widely expressed (PubMed:9535847, PubMed:23429263). Highly expressed in brain, kidney, and spleen (PubMed:27098698).
Database Links

KEGG: mmu:51800

STRING: 10090.ENSMUSP00000027499

UniGene: Mm.3295


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