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| Code | CSB-EP002658MO |
| Product Type | Recombinant Protein |
| Size | US$2466 |
| Uniprot No. | O88597 |
| Relevance | Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity). |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | Coiled-coil myosin-like BCL2-interacting protein |
| Species | Mus musculus (Mouse) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | MEGSKASSSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEEANSGEEPFIETRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK |
| Research Area | Epigenetics and Nuclear Signaling |
| Source | E.coli |
| Gene Names | Becn1 |
| Protein Names | Recommended name: Beclin-1 Alternative name(s): Coiled-coil myosin-like BCL2-interacting protein |
| Expression Region | 1-448aa |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Mol. Weight | 67.6kDa |
| Protein Description | Full Length |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Plays a central role in autophagy |
| Subcellular Location | Cytoplasm, Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein, Endosome membrane, Peripheral membrane protein, Endoplasmic reticulum membrane, Peripheral membrane protein, Mitochondrion membrane, Peripheral membrane protein, Endosome, Cytoplasmic vesicle, autophagosome |
| Protein Families | Beclin family |
| Database Links |
KEGG: mmu:56208 STRING: 10090.ENSMUSP00000119369 UniGene: Mm.178947 |
| Pathway |
Autophagy
Mitophagy Apelin signaling pathway |
Becn1 Antibodies for Mus musculus (Mouse)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002658ZA01MO | Becn1 Antibody | Mus musculus | ELISA, WB (ensure identification of antigen) |
Becn1 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002658MO CSB-BP002658MO CSB-MP002658MO |
Recombinant Mouse Beclin-1(Becn1) | Yeast Baculovirus Mammalian cell |
Recombinant Mouse Complement receptor type 2(Cr2),partial
Express system: Yeast
Species: Mus musculus (Mouse)
Recombinant Human Von Hippel-Lindau disease tumor suppressor(VHL)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Proteasome subunit beta type-8(PSMB8)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Pyruvate kinase isozymes R/L(PKLR)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Macaca mulatta Interleukin-15(IL15)
Express system: Yeast
Species: Macaca mulatta (Rhesus macaque)
