Recombinant Mouse Beclin-1(Becn1)

1. data demonstrate that disruption of the beclin 1-BCL2 complex is an effective mechanism to increase autophagy, prevent premature ageing, improve healthspan and promote longevity in mammals PMID: 29849149
2. HER2 interacts with Beclin 1 in breast cancer cells and inhibits autophagy. Mice with increased basal autophagy due to a genetically engineered mutation in Becn1 are protected from human HER2-driven mammary tumorigenesis, and HER2 fails to inhibit autophagy in primary cells derived from these mice. PMID: 29610308
3. Catalase ameliorates diabetes-induced cardiomyopathy through reduced RelA-mediated transcription of BECN1. PMID: 28643395
4. TRIM50, via the RING domain, ubiquitinates Beclin 1 in a K63-dependent manner enhancing its binding with ULK1 and autophagy activity. PMID: 29604308
5. findings suggested E. faecalis LTA may increased macrophages autophagy via inhibiting PI3K/Akt/mTOR pathway and this process was Beclin1 dependent. PMID: 29551680
6. The results suggest that SPK2 interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 and activating autophagy while protecting neurons against ischemic injury. PMID: 28682313
7. alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP activation, and enhanced macrophage beclin1 dependent autophagy. PMID: 28088783
8. These results suggest that the phosphorylated CAV1 functions to activate autophagy through binding to the BECN1/VPS34 complex under oxidative stress and to protect against ischemic damage. PMID: 28542134
9. Intracerebral hemorrhage contributes to microglia autophagic activation through BECN1 (and ATG5) pathway. PMID: 26732594
10. These data demonstrate the essential role of Beclin-1 in the formation of autophagosomes and lysosome biogenesis and underline that deletion of this key system is deleterious for cell viability. PMID: 26456737
11. AMP-activated protein kinase (AMPK) regulates autophagy by phosphorylating BECN1 at Thr388 PMID: 27304906
12. BECN1/Beclin 1 binding to viral phosphoprotein (P) induced an incomplete autophagy via activating the pathways CASP2-AMPK-AKT-MTOR and CASP2-AMPK-MAPK by decreasing CASP2. PMID: 28129024
13. proteostasis regulator cysteamine, which rescues the function of the most common F508del-CFTR mutant and hence reduces lung inflammation in CF patients, can also repair the defects of CF macrophages, thus restoring both bacterial internalization and clearance through a process that involves upregulation of the pro-autophagic protein Beclin 1 and re-establishment of the autophagic pathway. PMID: 28079883
14. Genetically disrupting BECN1-BCL2 binding hyperactivates autophagy in vivo, which sequestrates amyloid oligomers and prevents Alzheimer's disease progression. PMID: 28806762
15. Data show that 1-month of oral treatment with beta-asarone reduces AChE, Abeta42, APP and Beclin-1 levels and alleviates some behavioral impairments by inhibiting the autophagy via regulating the PI3K/Akt/mTOR pathway in APP/PS1 transgenic mice. The results further support the exploration of beta-asarone as a possible disease-modifying agent for the treatment of Alzheimer's disease. PMID: 27737765
16. identify FAK as a novel negative regulator of Beclin1-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth PMID: 27994061
17. The results not only demonstrate that BECN1 as a PI3K-III component is essential for cytokinesis, but also suggest that BECN1 is not associated with autophagy pathway in mouse oocytes. PMID: 27149384
18. this study shows that knockdown of beclin1 enhances macrophage-associated phagocytosis and intracellular killing of Pseudomonas aeruginosa PMID: 27295610
19. provide the novel evidence that GADD45A inhibits autophagy via impairing the BECN1-PIK3C3 complex formation PMID: 26636486
20. in-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death. PMID: 26386349
21. suggest that neuronal death induced by decreased beclin 1 levels may also be due to impaired trophic factor signaling PMID: 26692002
22. Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. PMID: 25275521
23. a mechanism of inverse coregulation between BECN1 and MCL1 significantly contributes to their opposing roles in tumorigenesis PMID: 25837021
24. FKBP5 associates with BECN1, changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux PMID: 25714272
25. identifies a novel negative regulator of autophagy and suggests that RNF216 may be a target for treatment of inflammatory diseases PMID: 25484083
26. Inverse co-regulation of Beclin 1 and Mcl-1 represents a mechanism of functional counteraction in cancer. PMID: 25472497
27. Beclin 1-mediated autophagy alleviates cerebral ischemic injury following down-regulation of miRNA-30a. PMID: 24771295
28. CFTR and BECN1 function can be restored with cysteamine and EGCG in a model of the F508del-CFTR mutation PMID: 25350163
29. a neuroprotective role for ARRB1, in the context of cerebral ischemia, centered on the regulation of BECN1-dependent autophagosome formation PMID: 24988431
30. Data show that beclin1 (Becn1) provides essential functions in the ovary that are essential for mammalian reproduction. PMID: 25246579
31. ALDH2 deficiency exacerbates the pressure overload induced cardiac dysfunction partly by inhibiting Beclin-1 dependent autophagy pathway. PMID: 25086229
32. These data support a dual role of BECN1 in amyotrophic lateral sclerosis. PMID: 24905722
33. Becn1 heterozygous knockout mice displayed a prolonged bleeding time and reduced platelet aggregation PMID: 24458007
34. Our findings demonstrate a novel protective effect of CO in sepsis, dependent on autophagy protein Beclin 1, in a murine model of CLP-induced polymicrobial sepsis PMID: 23971531
35. Beclin1 is involved, and might be responsible for the crosstalk between autophagy and apoptosis in mouse odontogenesis. PMID: 23793984
36. Suppression of the Beclin-1-dependent pathway reduced autophagy in pressure-overload heart failure. PMID: 24550138
37. Rhes robustly binds the autophagy regulator Beclin-1, decreasing its inhibitory interaction with Bcl-2 independent of JNK-1 signaling. PMID: 24324270
38. Mst1 promoted cardiac dysfunction in mice subjected to myocardial infarction by inhibiting autophagy, associated with increased levels of Thr108-phosphorylated Beclin1. PMID: 24141421
39. beclin 1 is required for efficient phagocytosis in a microglial cell line and in mouse brains. PMID: 24012002
40. ATG (BECN1 or ATG7) knockdown compromised mammary epithelial cell-mediated apoptotic body clearance in association with decreased RAC1 activation. PMID: 23380905
41. Lack of the beclin-binding domain increases autophagy response and activation of NLRP3 inflammasome, which in turn induces a more rapid innate immune response in HSV-1 infection. PMID: 23611643
42. Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress. PMID: 23589298
43. Attenuation of autophagy by a knockdown of beclin-1 enhanced neurons susceptibility to proapoptotic signals induced by amino acid starvation. PMID: 23011054
44. IL-2 induced HMGB1 cytoplasmic translocation in MEFs and promoted interaction between HMGB1 and beclin1, which is required for autophagy induction. PMID: 23195496
45. Aerosol delivery of beclin1 enhanced the anti-tumor effect of radiation in the lungs of K-rasLA1 mice PMID: 22843615
46. Bim inhibits autophagy by interacting with Beclin 1, an autophagy regulator, an interaction facilitated by LC8. PMID: 22742832
47. Ischemia/reperfusion injury impairs autophagosome clearance mediated in part by reactive oxygen species-induced decline in lysosome-associated membrane protein-2 and upregulation of BECLIN-1, contributing to increased cardiomyocyte death. PMID: 22592897
48. in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 interacts with the class III PI3K Vps34 in a complex with Beclin-1 and UVRAG PMID: 22493499
49. Beclin 1 coordinates actin dynamics and membrane phospholipid synthesis to promote efficient apoptotic cell engulfment with Rac1 PMID: 22393062
50. Beclin 1 is involved in regulation of apoptosis and autophagy during replication of ectromelia virus in permissive L929 cells. PMID: 21972018

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KEGG: mmu:56208

STRING: 10090.ENSMUSP00000119369

UniGene: Mm.178947