Recombinant Mouse C-C motif chemokine 6(Ccl6)

Code CSB-YP329756MO
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Source Yeast
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Code CSB-EP329756MO
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Source E.coli
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Code CSB-EP329756MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP329756MO
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Source Baculovirus
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Code CSB-MP329756MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ccl6
Uniprot No. P27784
Alternative Names Ccl6; C10; Scya6C-C motif chemokine 6; Protein C10; Small-inducible cytokine A6) [Cleaved into: CCL6(22-95); CCL6(23-95)]
Species Mus musculus (Mouse)
Expression Region 22-116
Target Protein Sequence GLIQEMEKE DRRYNPPIIH QGFQDTSSDC CFSYATQIPC KRFIYYFPTS GGCIKPGIIF ISRRGTQVCA DPSDRRVQRC LSTLKQGPRS GNKVIA
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
CCL6(22-95) and CCL6(23-95) are potent chemoattractants.
Gene References into Functions
  1. Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis. PMID: 20498053
  2. enhanced expression in intestinal epithelium following immunostimulation with LPS or pro-inflammatory cytokines PMID: 19812544
  3. the injury-induced expression of C10 at the mRNA and protein level PMID: 11895334
  4. c10 promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung PMID: 12356575
  5. CCL6 gene activation and production induced by SCF in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK/MAPK pathway but not the PI-3K pathway was crucial for the SCF-induced CCL6 gene activation. PMID: 17234680
  6. the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP PMID: 19171873

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Subcellular Location Secreted.
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
Database Links

KEGG: mmu:20305

STRING: 10090.ENSMUSP00000019071

UniGene: Mm.137

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