Ccl6 Antibody

Code CSB-PA031049
Size US$299
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA031049(Ccl6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No. P27784
Target Names Ccl6
Alternative Names Ccl6 antibody; C10 antibody; Scya6C-C motif chemokine 6 antibody; Protein C10 antibody; Small-inducible cytokine A6) [Cleaved into: CCL6(22-95); CCL6(23-95)] antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthetic peptide of Mouse CCL6
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:500-1:5000
IHC 1:25-1:100
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
CCL6(22-95) and CCL6(23-95) are potent chemoattractants.
Gene References into Functions
  1. Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis. PMID: 20498053
  2. enhanced expression in intestinal epithelium following immunostimulation with LPS or pro-inflammatory cytokines PMID: 19812544
  3. the injury-induced expression of C10 at the mRNA and protein level PMID: 11895334
  4. c10 promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung PMID: 12356575
  5. CCL6 gene activation and production induced by SCF in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK/MAPK pathway but not the PI-3K pathway was crucial for the SCF-induced CCL6 gene activation. PMID: 17234680
  6. the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP PMID: 19171873

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Subcellular Location Secreted.
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
Database Links

KEGG: mmu:20305

STRING: 10090.ENSMUSP00000019071

UniGene: Mm.137

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