Product Details

Purity

>85% (SDS-PAGE)

Target Names

Cd180

Uniprot No.

Q62192

Alternative Names

Cd180; Ly78; Rp105; CD180 antigen; Lymphocyte antigen 78; Ly-78; Radioprotective 105 kDa protein; CD antigen CD180

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.

Gene References into Functions

Silencing Cd180 results in increased phagocytosis while tempering the production of the proinflammatory cytokine TNF during Borrelia burgdorferi infection. PMID: 29511161
the close association between the increased proportion of CD180-negative B cells and the activation of IFN-alpha signaling in Systemic lupus erythematosus, is reported. PMID: 26277892
Data show that RP105 knockout (-/-) smooth muscle cells and mast cells secreted higher levels of chemokine (C-C motif) ligand 2 protein (CCL2). PMID: 27053419
These data unveil a novel innate immune signaling axis that orchestrates key cytokine responses of macrophages and provide molecular insight into the functions of RP105 as an innate immune receptor for mycobacteria. PMID: 26371254
RP105 regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model. PMID: 24945347
RP105 deficiency results in reduced early atherosclerotic plaque development with a marked decrease in lesional macrophage content, which may be due to disturbed migration of RP105 deficient monocytes resulting from CCR2 downregulation PMID: 25484103
Deficiency of the endogenous TLR4 inhibitor, RP105, leads to pronounced cardiac dilation after myocardial infarction. PMID: 25156852
Data indicate that RP105 and TLR4 are both expressed by vascular smooth muscle cells (VSMC). PMID: 23844130
RP105 deficiency on circulating cells results in an intriguing unexpected TLR-associated mechanisms that decrease atherosclerotic lesion formation with alterations on proinflammatory B2 B cells. PMID: 24115036
The function of TLR2 and TLR4 in response to TLR ligands could be associated with each other by RP105. PMID: 23483427
Data show that both RP105/MD-1 and TLR4/MD-2 are expressed in marginal zone (MZ) B cells. PMID: 22354914
The RP105/MD-1 complex is a major mediator of adipose tissue inflammation independent of TLR4 signaling and may represent a novel therapeutic target for obesity-associated metabolic disorders. PMID: 22396206
Modulation of B cell proliferation by RP105 is not a function of B cell-intrinsic expression of RP105. PMID: 22291190
Both mouse and human RP105/MD-1 exhibit dimerization of the 1:1 RP105/MD-1 complex, demonstrating a novel organization. PMID: 21959264
CD180 stimulation induces intrinsic B cell proliferation and differentiation PMID: 21918197
RP105 regulated TLR4 signaling in dendritic cells PMID: 15852007
A signal via RP105 is uniquely important for regulating Toll-like receptor-dependent antibody production to microbial membranes. PMID: 15905547
RP105 regulates the antigen-presenting cell function and Treg development, which induced the attenuation of the cell-mediated immune responses and, as a result, suppressed the development of collagen-induced arthritis . PMID: 18847495
The data identify RP105 as an accessory molecule for TLR2, forming part of the receptor complex for innate immune recognition of mycobacterial lipoproteins. PMID: 19154986

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Toll-like receptor family

Tissue Specificity

B-lymphocytes and spleen. Not detected in thymus, kidney, muscle, heart, brain or liver.

Database Links

KEGG: mmu:17079

STRING: 10090.ENSMUSP00000022124

UniGene: Mm.373974

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Recombinant Mouse CD180 antigen (Cd180), partial

Product Details

Customer Reviews and Q&A

Target Background

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