Recombinant Mouse Caspase recruitment domain-containing protein 10(Card10) ,partial

Code CSB-YP004515MO
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Source Yeast
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Code CSB-EP004515MO
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Source E.coli
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Code CSB-EP004515MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004515MO
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Source Baculovirus
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Code CSB-MP004515MO
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Card10; Bimp1Caspase recruitment domain-containing protein 10; Bcl10-interacting MAGUK protein 1; Bimp1
Mus musculus (Mouse)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Activates NF-kappa-B via BCL10 and IKK.
Gene References into Functions
  1. CARMA3 is gradually turned over following vesicular stomatitis virus infection, which may serve as a mechanism to turn off NF-kB activation, it releases MAVS to form functional aggregates to induce interferon regulatory factor 3 activation. PMID: 26947079
  2. CARMA3 is critical for the initiation of allergic airway inflammation. PMID: 26041536
  3. Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3.Bcl10.MALT1 signalosome PMID: 21041303
  4. the type 1 receptor for angiotensin II utilizes the CARMA3-Bcl10-MALT1 signalosome for activation of NF-kappaB in endothelial and vascular smooth muscle cells, thereby inducing pro-inflammatory signals within the vasculature PMID: 20605784
  5. CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in hepatocytes. PMID: 17101977
  6. Together, results provide the genetic evidence that CARMA3 is required for G protein-coupled receptor-induced NF-kappaB activation. PMID: 17438001
  7. Data demonstrate that lysophosphatidic acid stimulates thymic stromal lymphopoietin and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation. PMID: 18757306
  8. components of the CBM complex, Carma3, Bcl10, and Malt1 are key mediators of the CXCL8/IL8-induced NFkappaB activation and VEGF up-regulation. PMID: 19112107

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Tissue Specificity
Highly expressed in kidney, heart followed by brain, lung, liver, skeletal muscle and testis.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
7505 Fannin St Ste 610-322 Houston, TX 77054, USA
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