Recombinant Mouse Cell division control protein 6 homolog (Cdc6)

Code CSB-YP005022MO
MSDS
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Source Yeast
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Code CSB-EP005022MO
MSDS
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Source E.coli
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Code CSB-EP005022MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005022MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP005022MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Cdc6
Uniprot No.
Alternative Names
Cdc6Cell division control protein 6 homolog; CDC6-related protein; p62(cdc6)
Species
Mus musculus (Mouse)
Expression Region
1-562
Target Protein Sequence
MPQTRSQTQA TIGFPKKKLS NTLKKPNSRD CEVKLRNVQP VPTTPCVDVK LLPLSPRKRL GDDNLCNTPR LSPCSPPKLG KKENGPPRSH TWKGCRLVFD DEPTFKASPP KEQDRVRQHQ IRSSSAQRSP ESKADPEQKC PPEKESVCIR LFKQEGTCYQ QAKLVLNTAV PDRLPAREQE MGVIRNFLKE HICGKKAGSL YLSGAPGTGK TACLSRILQD FKKEVKGFKS ILLNCMSLRS AQAVFPAIAQ EIGREELCRP AGKDLMRKLE KHLTAEKGPM IVLVLDEMDQ LDSKGQDVLY TLFEWPWLSN SRLVLIGIAN TLDLTDRILP RLEARENCKP QLLNFPPYTR NQIAAILQDR LSQVSKDQVL DSAAIQFCAR KVSAVSGDIR KALDVCRRAI EIVESDVRSQ TVLKPLSECK SPSESPVPKR VGLAHISQVI SEVDGNRVTL SQENTQDSLP LQQKILVCSL LLLTRRLKIK EVTLGKLYEA YSSICRKQQV TAVDQSECLS LSGLLESRGL VGLKKNKESR LTKVSLKIEE KEIEHVLNGK AFTGNILAAG LP
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Gene References into Functions
  1. Dele and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function. PMID: 28655335
  2. CDK1 activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle PMID: 25264619
  3. Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation PMID: 22493447
  4. show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity. PMID: 20048262
  5. CDC6 is essential for spindle formation in mouse oocytes PMID: 15385409
  6. hCdt1 and hCdc6 expression promote malignant behavior PMID: 18006835

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Subcellular Location
Nucleus. Cytoplasm.
Protein Families
CDC6/cdc18 family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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