Recombinant Mouse Cytochrome P450 7A1 (Cyp7a1)

1. vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol. PMID: 29243851
2. Hypercholesterolemia in TALLYHO/jng mice might increase the Bile acids amounts via the interrupted Fxr/Fgf15/Fgfr4-mediated feedback regulation of Cyp7a1. PMID: 28843503
3. although feeding LS-Xbp1(-/-) mice cholesterol did not increase CYP7A1 expression, serum C4 levels increased significantly up to levels similar to chow-fed Xbp1(fl/fl) mice and the total bile acid pool normalized. In conclusion, loss of hepatic XBP1 decreased the bile acid pool and CYP7A1 synthetic activity. PMID: 28039331
4. Cyp7a1(-/-) mice have improved glucose sensitivity with reduced liver triglycerides and fecal bile acid excretion, but increased fecal fatty acid excretion and respiratory exchange ratio (RER) when fed a high-fat/high-cholesterol diet PMID: 27146480
5. Current studies suggest that increased Cyp7a1 expression and bile acid synthesis ameliorate hepatic inflammation through activation of FXR PMID: 27534992
6. HSF-1 ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 and MDR1/P-gp axis in WD-diet fed HSF-1(-/-)/LDLr(-/-) mice to reduce atherosclerosis. PMID: 27131506
7. Mice deficient in cholesterol 7 alpha-hydroxylase, supplemented with chenodeoxycholic acid, have altered liver and intestinal bile acids. PMID: 25447797
8. Activation of the VDR represses hepatic SHP to increase levels of CYP7A1 and reduce cholesterol. PMID: 24365583
9. Cholesterol lowering properties of oats involve increased production of bile acids via the classic pathway with up-regulation of CYP7A1 and CYP8B1. PMID: 23262749
10. A CYP7A1/SREBP2/miR-33a axis plays a critical role in regulation of hepatic cholesterol, bile acid, and fatty acid synthesis. PMID: 23536474
11. Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt(-/-)apoE(-/-) mice and was inversely correlated with expression of hepatic cholesterol 7-hydroxylase (Cyp7a1). PMID: 23880190
12. HNF4alpha and LRH-1 promote active transcription histone marks on the Cyp7a1 promoter that are reversed by FGF19 in a SHP-dependent manner PMID: 23038264
13. these data suggest that FGF7 is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis. PMID: 22713451
14. Results indicate that although PPARgamma activation increased PCSK9 expression, PPARgamma activation induced LDLR and CYP7A1 expression that enhanced LDL cholesterol metabolism. PMID: 22593575
15. Cyanidin-3-O-beta-glucoside consumption reduced hypercholesterolemia, promoted fecal bile acid excretion and upregulated hepatic cholesterol 7a-hydroxylase expression (CYP7A1). PMID: 22495986
16. Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice PMID: 22302708
17. Although gene expressions of HMG-CoAR and CYP7A1 in diabetic buckwheat sprout-fed groups were higher than in the diabetic control group, the elevation of mRNA level of CYP7A1 was greater than that of HMG-CoAR. PMID: 21535603
18. Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration. PMID: 21391220
19. induction of CYP7A1 expression and expansion of a hydrophobic bile acid pool stimulate cholesterol conversion into bile acids, de novo cholesterol synthesis, and biliary free cholesterol secretion, without increasing intestinal cholesterol absorption. PMID: 21319191
20. lack of stimulation of gene by dietary cholesterol PMID: 11967256
21. interaction of peroxisome proliferator-activted receptor alpha with liver x receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene promoter PMID: 12117567
22. transcription suppressed by alpha1-antitrypsin peptide via interaction with AFP PMID: 12223476
23. Feedback regulation of the rate-limiting biosynthetic enzyme CYP7A1 is lost in Cyp8b1(-/-) mice, causing expansion of the bile acid pool and alterations in cholesterol metabolism. PMID: 12393855
24. bile acids suppress transcription of the gene (CYP7A1) encoding cholesterol 7alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis PMID: 12865425
25. CYP7a1 synthesis is not stimulated by leptin PMID: 12917427
26. CYP7A1 is activated by PGC-1alpha PMID: 14522988
27. dietary cholesterol regulates bile acid pool size, fecal bile acid excretion, and plasma cholesterol independently of Cyp7a1 activity PMID: 14762172
28. LC omega-3 fatty acid-rich diet upregulated transcriptional level of Cyp7a1, D-site binding protein, and liver X receptor-alpha. PMID: 14960319
29. Cyp7a1 deficiency in APOE*3-Leiden mice decreases the VLDL particle production rate, as a consequence of a strongly reduced bile acid biosynthesis, leading to a decrease in plasma triglycerides. PMID: 14962946
30. Expression of gene Cyp7a1 indicates hepatic differentiation in embryonid bodies. PMID: 15569160
31. Hepatic neutral cytosolic cholesteryl ester hydrolase decreased mRNAs for cholesterol 7alpha-hydroxylase, sterol 27-hydroxylase, and HMG-CoA reductase on day 7 after transfection, coinciding with peak hepatic free cholesterol concentrations PMID: 15825828
32. LDL receptor-deficient mice expressing the CYP7A1 transgene exhibited complete resistance to diet-induced hypercholesterolemia and to the accumulation of cholesterol in the liver. PMID: 16609145
33. Identification of two new functional thyroid hormone receptor-binding sites in the CYP7A1 5' flanking sequence located 3 kb upstream from the transcription start site. PMID: 16899449
34. Strongly reduced bile acid synthesis in Cyp7a1-/-.APOE*3-Leiden mice leads to increased plasma HDL-cholesterol levels, as related to an increased hepatic expression of ABCA1. PMID: 17008588
35. The expression pattern of Cyp7a1 was studied in hepatocytes. PMID: 17237956
36. SREBP-1c functions as a non-DNA-binding inhibitor and mediates, in part, suppression of Cyp7a1 by blocking functional interaction of HNF-4 and PGC-1alpha PMID: 17636037
37. PGC-1alpha is an important co-activator for LRH-1 and that SHP targets the interaction between LRH-1 and PGC-1alpha to inhibit CYP7A1 expression. PMID: 18385139
38. The mouse Cyp7A1 promoter, used for trasient transfection of fluorescent gene reporters in ES spontaneously differentiated into hepatocytes, was better than the albumin promoter for cell sorting. PMID: 18942772
39. Results suggest that CYP7a1 suppression is required for liver protection after 70% partial hepatectomy and there are two distinct phases of CYP7a1 gene regulation during liver regeneration. PMID: 19056864
40. The present findings demonstrate that IL-1alpha and IL-1beta are positive regulators for the Cyp7a1 gene in steady-state mice and that Cyp7a1 is one of the factors that mediate the difference in serum total cholesterol level between sexes. PMID: 19101514
41. the AU-rich RNA binding-protein Apobec-1 mediates post-transcriptional regulation of Cyp7a1 expression and influences susceptibility to diet-induced gallstone formation PMID: 19386592
42. Impaired regulation of FoxO1 may cause down-regulation of CYP7A1 gene expression and contribute to dyslipidemia in insulin resistance. PMID: 19463968

Show More

Hide All

KEGG: mmu:13122

STRING: 10090.ENSMUSP00000029905

UniGene: Mm.57029