Recombinant Mouse Core histone macro-H2A.1 (H2afy)

1. These data indicate that macroH2A1.1-containing chromatin regulates mitochondrial respiration by limiting nuclear NAD(+) consumption and establishing a buffer of NAD(+) precursors in differentiated cells. PMID: 28991266
2. Both histone H3 lysine 27 acetylation and recruitment of the transcription factor Pbx1 at prospective enhancers are regulated by mH2A1.2. PMID: 26832413
3. The Skp2-mH2A1-CDK8 axis has a critical role in breast cancer development via dysregulation of the G2/M transition, polyploidy, cell growth dysregulation, and loss of tumor suppression. PMID: 25818643
4. tumor suppressive histone variant macroH2A1 is a critical component of the positive feedback loop that maintains the cell senescence-associated secretory phenotype, including activation of ATM PMID: 26300260
5. The macroH2A, a critical component of chromatin, suppresses the development of melanoma through regulating cyclin D1, cyclin D3 and CDK6 genes. PMID: 25119498
6. Data show that MacroH2A.1 and macroH2A.2 regulate gene expression with them acting synergistically on the expression of some genes and apparently having opposing effects on others. PMID: 25312643
7. The results demonstrate that macroH2A1 is a new factor involved in the regulation of rDNA transcription. PMID: 24071584
8. Both macroH2A1 isoforms may play a role in hepatocellular carcinoma pathogenesis. PMID: 23372727
9. macroH2A1 and macroH2A2, together with histone 3 lysine 27 methylated 3, co-occupy pluripotency genes in wild-type (wt) fibroblasts. PMID: 23463008
10. macroH2A1 is a critical chromatin component that regulates the delicate balance between self-renewal and differentiation of embryonic and adult stem cells PMID: 22331466
11. H2AFY is specifically overexpressed in two models of Huntington disease PMID: 21969577
12. MacroH2A1 does not localize to the centrosome. PMID: 21364955
13. Decreased stability of the inactive X chromosome is revealed in mouse epiblast stem cells, highlighting the importance of combinatorial epigenetic repression involving macroH2A in restricting transcriptional reprogramming by oocytes. PMID: 21552206
14. Knockdown of mH2A isoforms in melanoma cells of low malignancy results in significantly increased proliferation and migration in vitro and growth and metastasis in vivo PMID: 21179167
15. macroH2A1 functions primarily as a repressor in adult liver. This repressor activity is further supported by the substantial and relatively uniform macroH2A1 enrichment along the inactive X chromosome, which averages 4-fold. PMID: 20937776
16. C-terminal amino acids of H2A.X function specifically to target this variant histone into chromatin in embryos after fertilization and that the absence of H2A.Z and macroH2A from the chromatin is required for normal development. PMID: 20943707
17. Rapid elimination of MacroH2A from somatic cell heterochromatin after nuclear transfer is reported. PMID: 20132012
18. distributed during the maintainance phase of x inactivation throughout cell cycle PMID: 12082075
19. A maternal store of macroH2A is removed from the maternal genome prior to synkaryogamy. PMID: 15680357
20. distribution of macroH2A1 histone variants in liver chromatin PMID: 16738309
21. The function of macroH2A1 histones is not restricted to gene silencing but also involves fine tuning the expression of specific genes. PMID: 17242180
22. macroH2A1 histones have a significant role in silencing endogenous MLVs in vivo. Specific internal MLV sequences are targeted by a macroH2A1-dependent silencing mechanism. PMID: 18195046

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KEGG: mmu:26914

STRING: 10090.ENSMUSP00000016081

UniGene: Mm.283802