Recombinant Mouse Cyclin-A2 (Ccna2)

1. We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice. PMID: 27425845
2. cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle. PMID: 28819014
3. These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis. PMID: 27657745
4. Meioc-deficient spermatocytes that have initiated synapsis mis-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program. PMID: 28380054
5. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2, and E2F1 proteins. PMID: 28003426
6. cyclin A2 controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation. PMID: 27708105
7. hese data suggest that mmu-miR-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K and CCNA2 expression. PMID: 27020049
8. Ccn2 is a regulator of the transition through cytokinesis during terminal erythropoiesis. PMID: 25615569
9. Loss of CCNA2 decreases cell proliferation and induces cerebellar cortical dyslamination. PMID: 25668568
10. Data indicate that cyclin A2-depleted epithelial cells adopt a fibroblastic morphology and undergo epithelial to mesenchymal transition (EMT). PMID: 24879294
11. The activity of PCTK3 is increased via interaction with cyclin A2 and phosphorylation by PKA. PMID: 24831015
12. AMPKalpha1 controlled cyclin A2 transcription mainly through the ATF/CREB element PMID: 24012615
13. Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. PMID: 24802190
14. Conditional knockout of cyclin A2 or the SHH proliferative target Nmyc in CGNP also resulted in PC neuron dyslamination PMID: 24184637
15. decreased miR-124 expression could increase CCNA2 in cell and animal model of HD and is involved in deregulation of cell cycle in STHdh(Q111)/Hdh(Q111) cells PMID: 23796713
16. The requirement of cyclin A2 for entry into meiosis I and for sister chromatid segregation in meiosis II in mouse oocytes. PMID: 23122964
17. Cyclin A expression confirmed a prolifer-ative response in cirrhotic livers in response to mitogens. PMID: 22243368
18. Study suggested that OGP may increase the bone formation in OPG-deficient mice by stimulating MSC proliferation rather than differentiation, and probably by triggering CDK2/cyclin A pathway. PMID: 20926513
19. CCN1 is a novel, endogenous "parent compound" for chemotaxis modulation. PMID: 21135363
20. transcription of the gene for cyclin-A2 appears to be a direct target of JDP2 in the suppression of cell proliferation PMID: 20802531
21. cyclin A may induce S phase arrest associated with apoptosis in 3-methylcholanthrene-induced fibrosarcomas. PMID: 18621517
22. cyclin A expression is inhibited by bicalutamide both in androgen-dependent and -independent cell lines PMID: 20126974
23. CCN1 is a novel component of the extracellular matrix that activates proinflammatory genes in macrophages, implicating its role in regulating macrophage function during inflammation. PMID: 20164416
24. Data show that the presence of the truncated form of cyclin A2 in differentiating embryonic stem cells is not a function of cell density but is correlated with differentiation. PMID: 12646244
25. cyclin A levels are regulated by c-Fos in osteoblast growth control PMID: 14699150
26. critical role in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium. PMID: 15159393
27. expression pattern during the first three cell cycles of mouse embryo development PMID: 15214576
28. B-Myb represses SMC elastin gene expression and cyclin A plays a role in the developmental regulation of elastin gene expression in the aorta PMID: 15615710
29. recruitment of maternal cyclin A2 mRNA following egg activation is linked to embryonic gene activation PMID: 16137671
30. Expression of cyclin A2 augments endogenous regenerative mechanisms via induction of enhanced cell proliferative capacity. Ability of cultured transgenic cardiomyocytes to undergo cytokinesis provides support for the regenerative capacity of cyclin A2. PMID: 17495221
31. Results indicate that the NFAT1 transcription factor represses cyclin A2 expression in lymphocytes, and may act as a silencer of gene transcription during the cell cycle. PMID: 17637565
32. PtdIns(4,5)P2 down-regulation caused a delay in phorbol ester-induced S phase entry and that this was at least in part channeled through cyclin A2 at the transcriptional level. PMID: 18077453
33. REVIEW.Some cyclins exhibit unique patterns of expression in germ cells that suggest possible concomitant distinct functions; embryonic lethality has obviated understanding of the germline functions of cyclin A2 and cyclin B1 PMID: 19001847
34. cyclin A2-Cdk1 is a key regulator of S-phase programs PMID: 19221029
35. Results identify the phosphorylated residues in mouse Cyclin-A2 and CDK2 recombinant proteins, after individual expression and after formation of the heterodimer complex. PMID: 19233286
36. MLL5 plays an integral role in novel chromatin regulatory mechanisms that suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. PMID: 19264965
37. Study found that acute ablation of cyclin A in fibroblasts did not affect cell proliferation, in contrast, cyclin A function was essential for cell-cycle progression of hematopoietic and embryonic stem cells. PMID: 19592082

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KEGG: mmu:12428

STRING: 10090.ENSMUSP00000029270

UniGene: Mm.4189