Recombinant Mouse Cyclin-dependent kinase 4 inhibitor C (Cdkn2c)

1. Gata3 deficiency promotes B cell differentiation and proliferation, and cooperates with p18 loss to induce B cell lymphomas PMID: 27588406
2. Host Tumor Suppressor p18(INK4c) Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis. PMID: 29298882
3. CD4+ T cells from mice genetically deficient for p18ink4c divide more rapidly than wild-type cells in response to antigenic, costimulatory and growth factor signals. PMID: 24614758
4. p18 represents a potent and specific target for enhancing the self-renewal property of HSC, as demonstrated the effect of inhibitors PMID: 25692908
5. p18 may play protective roles and may be associated with or partially account for the cytoprotective effects of HO-1 in cisplatin-induced acute kidney injury. PMID: 24993528
6. Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. PMID: 24167278
7. deletion of P18 results in a deacreased proliferation of hematopoietic progenitor cells (HPCs) suggesting a positive role for P18 on HPCs in vivo PMID: 21936707
8. A p18 -74 C/T mutation is the leading causal variant for the cell expansion that characterizes NZB and NZM2410 lupus-prone mouse strains. PMID: 22504641
9. Cdkn2c plays a critical role in B1a cell self-renewal and its impaired expression leads to an accumulation of these cells with high autoreactive potential. PMID: 21543644
10. define the first physiologic function for Noxa and suggest that by repressing Noxa, induction of G arrest by p18INK4c bypasses a homeostatic cell-cycle checkpoint in intermediate plasma cells (iPCs) for PC differentiation PMID: 21163929
11. CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells PMID: 12196289
12. Here we show that treatment of p18 null and heterozygous mice with a chemical carcinogen resulted in tumor development at an accelerated rate.Hence, p18 is a haploinsufficient tumor suppressor in mice. PMID: 12556487
13. p18 is involved in cell cycle progression after partial hepatectomy. PMID: 12668976
14. Ink4 proteins might function in governing neuronal cell cycle exit as well as in a non-cell-autonomous manner in controlling the production of diffusible mitogens and chemokines that influence postnatal development of the cerebellar EGL. PMID: 14500377
15. p19(INK4d) in addition to p21(WAF1/Cip1) is an important molecular target of HDAC inhibitors inducing growth arrest PMID: 15107822
16. Results show that deletion of p18(INK4C) results in strikingly improved long-term engraftment, largely by increasing self-renewing divisions of the primitive cells in murine transplant models. PMID: 15122268
17. p18(Ink4c) is functionally dependent on CDK4 PMID: 15254233
18. Antagonistic cell-cycle regulation by tumor necrosis factor (ligand) superfamily, member 13b and p18(INK4c) is functionally linked to apoptotic control PMID: 15591344
19. Coinactivation of Ink4c and p53 provides cultured cerebellar granule neuronal precursor cells with an additive proliferative advantage and induces medulloblastoma with low penetrance but with greatly increased incidence following postnatal irradiation. PMID: 16260494
20. p18Ink4c and Pten cooperate in tumor suppression by constraining a positive regulatory loop between cell growth and cell cycle control pathways. PMID: 16738322
21. Results describe the expression of p18(Ink4c) and p19(Ink4d) in spermatogenic and supporting cells in the testis and in pituitary gonadotropes. PMID: 17342741
22. Data suggest that EKLF is a direct regulator of p18(INK4c) gene expression, and much of EKLF's role in driving erythroid cell differentiation may occur via p18(INK4c). PMID: 17442339
23. oncogenic RET and loss of p18 cooperate in the multistep tumorigenesis of medullary thyroid carcinoma PMID: 18316595
24. Studies identify p18(INK4c) as a glioblastoma multiforme tumor suppressor gene, revealing an additional mechanism leading to aberrant activation of cyclin/cdk complexes in this terrible malignancy. PMID: 18381405
25. p18Ink4c and p19Ink4d protein levels are not only differentially regulated by the ubiquitin-proteasome pathway, but are subject to completely opposite modes of regulation when associated with their target Cdks. PMID: 19029828
26. Cdk4 inhibitor p18(Ink4c) is a tumor suppressor in cyclin D1-driven PNET. PMID: 19147556
27. p18(INK4C) is a downstream target of GATA3, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland PMID: 19411068

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KEGG: mmu:12580

STRING: 10090.ENSMUSP00000070313

UniGene: Mm.1912