Recombinant Mouse Ephrin-A5 (Efna5)

1. that Epha2 and Efna5 participate in the complex, global patterning of lens fiber cells that is necessary for maximal optical quality PMID: 29800803
2. This study demonstrated for a role of ephrinA signaling for the selective targeting of serotonergic raphe nuclei. We show that EphA5 is differentially expressed across the different hindbrain raphe nuclei, and that this correlates with a different repulsive action of ephrinA on 5-HT axon growth. PMID: 28197551
3. these results suggest that the basic helix-loop-helix transcription factorsbinding site in ECR1 is involved in the positive regulation of ephrin-A5 gene expression during the development of the mesencephalon. PMID: 28614915
4. During urogenital development, different modes of Eph/Ephrin signaling occur at several sites with EphrinB2 and EphrinA5 acting in concert. PMID: 27344203
5. dissociations of N-cadherin and adherens junctions in the associated interlocking domains may result in the formation of isolated globules and nuclear opacities in the ephrin-A5(-/-) mice. PMID: 26643403
6. Overexpression of Ephrin-A5 in mice results in decreasing the size of progenitor pool through inducing apoptosis. PMID: 26674965
7. Ephrin-A5 interacts with Ephrin-A4 to modulate neurogenesis and angiogenesis in a model of temporal lobe epilepsy. PMID: 25502292
8. Data show the effects of genetic loss of ephrin-A5, Eph receptors EphA4, and EphA7 on the development of medulloblastoma tumors in the smoothened (Smo) transgenic mouse model. PMID: 26345456
9. the unique cross-subclass interaction of EphB2 with ephrin A5 has evolved to function upstream of JNK signaling for the purpose of maintaining an adequate pool of progenitor cells to ensure proper closure of the optic fissure. PMID: 26839344
10. Female mice lacking EFNA5 are subfertile, exhibit a compromised response to LH, and display abnormal ovarian histology after superovulation. PMID: 26672804
11. NF-kappaB in NG2(+) cells promotes myoblast migration to the tips of myofibers through cell-cell contact through expression of ephrinA5 from NG2(+) cells PMID: 26777211
12. The reduced nuclear size and diminished gene expression mirrors subtle changes in ephrin A5 expression evident in P1 and P4 enucleated neocortex, 11 and 8 days prior to natural eye opening, respectively. PMID: 26452243
13. These data support the hypothesis that the retinocollicular projection is a superimposition of a number of individual two-dimensional topographic maps that originate from specific types of RGCs, require ephrin-A signaling. PMID: 25649160
14. Ephrin A2 and Ephrin-A5 are important for the functional development of cutaneous innervation. PMID: 25243788
15. ephrin A5 ligands imported by invading thalamic axons interact with EphA4-expressing radial glial cells. PMID: 25480914
16. data show that ephrinA5 drives repellent interactions between temporal and nasal axons within the superior colliculus, and demonstrates for the first time that target-independent mechanisms play an essential role in retinocollicular map formation in vivo. PMID: 25451192
17. multi-protein complex comprising ephrinA5, EphA7, and TNFR1 may constitute a platform for inducing caspase-dependent apoptotic cell death PMID: 23657875
18. Ephrin-A5 has a critical role in postnatal lens fiber organization to maintain lens transparency PMID: 23401654
19. Complementary expression of ephrin-A5 in hair cells and EphA4 receptor among spiral ganglion neuron populations controls the targeting of type I and type II afferent fibres to inner and outer hair cells, respectively. PMID: 23385583
20. ephrin-A5 expression appears to be critical for proper development of central monoaminergic pathways and that its loss results in a number of neurodevelopmental abnormalities PMID: 22954718
21. Ephrin-A5 is induced in reactive astrocytes in periinfarct cortex and is an inhibitor of axonal sprouting and motor recovery in stroke. PMID: 22837401
22. In a growth cone collapse assay, mouse embryonic stem cell-derived spinal motor neurons respond to ephrin-A5, semaphorin(Sema)3f, and Sema3a in a concentration-dependent manner. PMID: 22279234
23. Results demonstrated that the ephrinA5-EphA4/EphA5 system plays an important role in the direct pathway-dependent regulation of the SNr in cocaine responses and would provide valuable therapeutic targets of cocaine addiction. PMID: 21628570
24. Our work shows that ephrinA5 protein is expressed in restrictive regions of the developing mouse brain PMID: 20738842
25. EphA/ephrin-A signaling plays crucial roles in the establishment and/or maintenance of the brain vascular system, as an essential constituent of the adult neurogenic niche. PMID: 20474079
26. Results indicate that on postnatal day 8 (P8), the dendrites in mutant animals exhibit more filopodia and are more branched than dendrites of wildtype cells; on P23, dendrites are still more branched, but possess fewer spines than wildtype cells. PMID: 19827157
27. Optic nerve section in adult rat regulates the expression of EphA5 in the retina.EphA5 was expressed as an increasing naso-temporal gradient. By 1 month, expression was decreased resulting in a uniform expression across the naso-temporal axis. PMID: 11860487
28. Involved in embryonic axon guidance of limbic thalamocortical projections; gene knockout results in "miswiring" of these pathways PMID: 12417660
29. Ephrin A5 receptor in the thalamus and ephrin A5 in the cerebral cortex control intra-areal topographic mapping of thalamocortical axons. PMID: 12895420
30. positional differences in axon terminal areas are eliminated with ephrin-A5 overexpression PMID: 15527895
31. We conclude that ectopic expression of ephrin A5 in murine fibroblasts elevates oncogenic potential, including increased invasive behaviour, anchorage-independent growth, and morphological transformation. PMID: 17022942
32. Ephrin-A5 enhances the motility of cortical neurons that is dependent on the activity of Src-family kinases; Ephrin-A5 further changes the adhesive properties of neurons by inducing the formation of cell aggregates. PMID: 17522309
33. ephrin-A5 specifically regulates branch formation of thalamic axons, but does not affect target layer selection PMID: 18463505
34. Results compare gene expression patterns in the somatosensory cortex of wild type and ephrinA5 deficient mice, which exhibit subtle, but highly reproducible alterations of thalamocortical projections and intrinsic cortical circuits. PMID: 18619851
35. Results suggest that ephrin-A5 acts as an inhibitory flank that contributes to define the pathway of migrating interneurons. PMID: 18662335
36. Ephrin-A5 and B1 localization and signaling in murine fibroblasts and tissues were examined. PMID: 18694724
37. Analysis of the striatal patterning in ephrin A5/EphA4 mutant mice revealed the requirement of EphA4 signalling for the proper sorting of matrix and striosome neuronal populations in vivo. PMID: 18755772
38. ephrin-A5 interacts with the EphA2 receptor to regulate the adherens junction complex, a key role in lens fiber cell shape and cell-cell interactions PMID: 18948590
39. ephrinAs and more specifically ephrinA5, may be actors in the guidance of dopaminergic projections PMID: 19576892

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KEGG: mmu:13640

STRING: 10090.ENSMUSP00000076115

UniGene: Mm.401670