Recombinant Mouse Excitatory amino acid transporter 1 (Slc1a3), partial

1. glutamate transporter function by GLAST on Bergmann glia plays important roles in development and maintenance of proper synaptic wiring and wrapping in Purkinje cells PMID: 28655840
2. Loss of EAAT4 accounts for the initial hyper-excitability of Purkinje cells lacking b-III spectrin and that loss of GLAST appears to work synergistically to worsen motor deficits. When levels of both EAAT4 and GLAST are compromised in b-III(-/-) mice, the proximal dendrites of Purkinje cells within the posterior cerebellum are the most vulnerable to degeneration. PMID: 28173092
3. The results of this study concluded that EAAT anion channels play an important and unexpected role in adjusting glial intracellular anion concentration during maturation and in response to cerebellar activity. PMID: 27859594
4. SLC1A3 maintains a constant import of acidic amino acids independently of nutritional status in adipocytes. PMID: 28032905
5. glutamate/aspartate transporter (GLAST) was elevated in 8- to 10- and/or 20- to 22-month GHR-KO mice when comparing genotypes PMID: 25711529
6. This study findings demonstrate that Ascl1(CreERT2) and Glast(CreERT2) mouse lines enable simple and reliable labeling of adult-born GC lineages within restricted time windows. PMID: 26586824
7. arundic acid treatment prevented RGC death by upregulating GLAST in heterozygous (GLAST(+/-)) mice PMID: 25789968
8. Results show that expression of GLAST is decreased in cerebellar astrocytes in a mouse model of SCA1; decrease occurs in non-cell autonomous manner late in disease and correlates well with the loss of Purkinje neurons PMID: 25255716
9. The result showed significant correlation between changes in GLUT 8 and glucose levels with changes in StAR level in the testis and circulating testosterone level in the mice from birth to senescence PMID: 25078271
10. EAAT1 activity and sodium potassium-ATPase activity are co-regulated by a tightly coupled homeostatic relationship in astrocytes. PMID: 24095695
11. TNR is expressed in a subset of astrocytes and contributes to glutamate homeostasis by regulating astrocytic GLAST expression. PMID: 24337573
12. Results suggest that an impairment of astrocytic ascorbate-release may exacerbate neuronal dysfunction in neurodegenerative disorders and acute brain injury in which excitotoxicity and/or GLAST deregulation have been implicated. PMID: 22886112
13. deletion appeared to preferentially affect the maintenance of a normal postsynaptic/neuronal phenotype, evident only with increasing age PMID: 22350511
14. BDNF can up-regulate GLAST and GS and increase glutamate uptake during hypoxia, and these functions may underlie its neuroprotective effects. PMID: 21448920
15. Together, these studies strongly suggest that NF-kappaB contributes to neuron-dependent regulation of astrocytic GLT-1 transcription. PMID: 21697367
16. Glutamate substrate increases GLAST activity and up-regulates the expression of GLAST protein in retinal Muller cells. PMID: 18844020
17. Increased susceptibility to seizures in GLAST (-/-) mice is due to increased Glu-R1 in the hippocampus coupled with decreased cortical Glu-R2 and increased NMDA-R1 and -2A, -2B expression. PMID: 12225864
18. GLT-1 and GLAST glutamate transporters are early and selectively expressed in barrel cortex of newborn mice. Confocal and electron microscopy confirm that the expression is restricted to the astroglial membrane. PMID: 12967927
19. This study found that the retinal GABA level was about two-fold higher in the GLAST-/- mouse retina compared to that in the wild type. Endogenous glutamate level was also increased about 2-fold in the mutant. PMID: 15305132
20. Glutamate uptake assays indicated that the Km value for glutamate uptake was similar in wild-type and GLAST-/- mouse retinas PMID: 15390100
21. Lactate production and release not altered in retinas of GLAST -/- mice, suggesting that metabolic coupling between photoreceptors and Muller cells is not mediated by glial glutamate transporter, GLAST. PMID: 15579226
22. GLAST protein contributes mainly to the uptake of glutamate that floods out of the synaptic cleft at early times after transmitter release. PMID: 16177048
23. Tg mice carrying the human FRDP-17 mutant of tau protein manifest compromised motor function that correlates with altered expression of the glial glutamate-aspartate transporter and occurs before the development of tau pathology. PMID: 16407562
24. Decreased glutamate transporter is associated with Niemann-Pick disease, type C PMID: 16429462
25. This result demonstrates that GLAST plays a role in preventing excitotoxic cerebellar damage after ischemia in concert with EAAT4. PMID: 16647773
26. evidence for a Glu-dependent regulation of GLAST protein levels and activity, and an increase in AP-1 DNA binding activity to the glast promoter that is strictly dependent on AMPA receptor activation was found PMID: 17151912
27. Data show that GLT-1 of EL mice at 5 weeks of age decreased more than those of DDY at the same age. PMID: 18621028
28. EAATs play an early homeostatic and protective role in the pathologic milieu. Moreover, the differential profiles of injury produced by oxidative and excitotoxic insults identify two distinct phases of injury which parallel important aspects of ALS. PMID: 18661557
29. GLAST-deficient mice exhibited abnormalities on certain behavioral measures considered relevant to the negative and attentional/cognitive symptoms of schizophrenia PMID: 19078949

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KEGG: mmu:20512

STRING: 10090.ENSMUSP00000005493

UniGene: Mm.204834