Recombinant Mouse FUN14 domain-containing protein 1 (Fundc1), partial

Code CSB-YP861601MO1
MSDS
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Source Yeast
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Code CSB-EP861601MO1
MSDS
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Source E.coli
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Code CSB-EP861601MO1-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP861601MO1
MSDS
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Source Baculovirus
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Code CSB-MP861601MO1
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Fundc1
Uniprot No.
Alternative Names
Fundc1; FUN14 domain-containing protein 1
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Gene References into Functions
  1. By facilitating Mff-mediated mitochondrial fission and FUNDC1-required mitophagy, NR4A1 disturbed mitochondrial homeostasis, enhanced endothelial apoptosis and provoked microvascular dysfunction in myocardial ischemia reperfusion injury. PMID: 29744594
  2. FUNDC1 is required for cardiac ischemia reperfusion injury activated mitophagy. PMID: 28732308
  3. hypoxic preconditioning induces FUNDC1-dependent mitophagy in platelets and reduces Ischemia/Reperfusion-induced heart injury, suggesting a new strategy to protect cardiac function and fight cardiovascular diseases. PMID: 28323531
  4. FUNDC1 binds to IP3R2 to modulate ER Ca(2+) release into mitochondria and cytosol. Disruption of the FUNDC1 and IP3R2 interaction lowers the levels of Ca(2+) in mitochondria and cytosol, both of which instigate aberrant mitochondrial fission, mitochondrial dysfunction, cardiac dysfunction, and heart failure. PMID: 28942427
  5. MicroRNA-137 has a role in inhibiting mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX PMID: 24573672

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Subcellular Location
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein Families
FUN14 family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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