Recombinant Mouse Fibroblast growth factor 18 (Fgf18)

1. Study found that Fgf18 mRNA was one of the spinal motor neurons (SMNs)-specific FGFs in adult mice. Fgf18 mRNA was expressed in the spinal cord, and to a lesser extent in the diaphragm, in mouse embryos. In C2C12 myotubes, FGF18 enhanced AChR clustering. These data propose that FGF18 plays a pivotal role in AChR clustering and NMJ formation in mouse embryogenesis. PMID: 29323161
2. Elevation of FGF signaling, mainly due to increased Fgf18 expression upon inactivation of Evc2 in the perichondrium, critically contributes to the pathogenesis of limb dwarfism. The limb dwarfism phenotype is partially rescued by inactivation of one allele of Fgf18 in the Evc2 mutant mice PMID: 28027321
3. Loss of alleles of Fgf9 and Fgf18 also affect the expression of genes encoding other key intrinsic skeletal regulators, including IHH, PTHLH (PTHrP), and RUNX2, revealing potential direct, indirect, and compensatory mechanisms to coordinate chondrogenesis and osteogenesis. PMID: 26794256
4. retinoic acid is produced by pulmonary endothelial cells and regulates pulmonary angiogenesis and elastin synthesis by induction of VEGF-A and fibroblast growth factor (FGF)-18, respectively PMID: 26566904
5. novel Shh-Foxf-Fgf18-Shh circuit in the palate development molecular network, in which Foxf1 and Foxf2 regulate palatal shelf growth downstream of Shh signaling, at least in part, by repressing Fgf18 expression PMID: 26745863
6. post-natal induction of chondrocyte autophagy is mediated by the growth factor FGF18 through FGFR4 and JNK-dependent activation of the autophagy initiation complex VPS34-beclin-1 PMID: 26595272
7. Phlpp1 deficiency increases Akt2 activity, which diminishes FoxO1 levels and induces Fgf18 expression to stimulate chondrocyte proliferation. PMID: 25953896
8. Foxp1 regulates the quiescent stem cell state in the hair follicle stem cell niche by controlling Fgf18 expression. PMID: 23946441
9. These findings therefore argue for an involvement of FGF18 in the control of various developmental events during the alveolar stage. PMID: 21878612
10. Fgf-18 is an important mediator of bone regeneration, which is required during later stages of bone regeneration. PMID: 21457097
11. FGF18 is upregulated during osteoblast differentiation induced by dexamethasone in murine mesenchymal stem cells. PMID: 20432451
12. Regulation of Hmgn1 and Fgf18 at the digit-interdigit junction suggests retinoic acid controls tissue remodeling as well as apoptosis. PMID: 20034106
13. Data revealed interaction between Glg1 and Fgf18 both genetically and physically and reveals a novel regulatory mechanism for Fgf18 signaling involving Glg1 and Dlk. PMID: 20023171
14. The expression from early streak stage to midgestation of Fgf18 is measured. It is, closely related to Fgf8 (56.8% identical at the amino acid level). Fgf18 RNA is not expressed until later, in paraxial mesoderm. PMID: 9651520
15. FGF-18 may therefore compensate for the action of FGF-2 on bone and cartilage. PMID: 11741978
16. expression of FGF18 in calvarial and limb development PMID: 11900978
17. Fibroblast growth factor 18 influences proximal programming during lung morphogenesis PMID: 11927601
18. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18 PMID: 11937493
19. FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis PMID: 11937494
20. FGF18 represses noggin expression and is induced by calcineurin PMID: 15252029
21. Cell proliferation in the Fgf18-/- lungs was also transiently reduced in embryonic lung alveoli. PMID: 15336546
22. data identified fibroblast growth factor (FGF) 18 as a selective ligand for fibroblast growth factor receptor 3(FGFR3) in limb bud mesenchymal cells, which suppressed proliferation and promoted their differentiation and production of cartilage matrix PMID: 15781473
23. These findings support a model in which FGF18 regulates skeletal vascularization and subsequent recruitment of osteoblasts/osteoclasts through regulation of early stages of chondrogenesis and VEGF expression. PMID: 17014841
24. FGF18 may play a prominent role in chondrogenesis and osteogenesis during skeletal development and growth (review) PMID: 17128416
25. Fgf18 may function as an essential component of the Wnt-dependent steps of osteoblastogenesis that are genetically downstream of Runx2. PMID: 17158875
26. promotion of osteoblast differentiation by Glis3 involves increased expression of FGF18 PMID: 17488195
27. Data indicate that FGF18 and FGFR3 are involved, possibly as partners, in the control of intestinal precursor cell proliferation. PMID: 18286540
28. FGF18 provided both directional and proliferative cues to chondrocytes in the developing upper respiratory tract. PMID: 19358209

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KEGG: mmu:14172

STRING: 10090.ENSMUSP00000020507

UniGene: Mm.339812