Recombinant Mouse Fibroblast growth factor 20 (Fgf20)

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Code CSB-EP008626MO
Size US$554
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Greater than 85% as determined by SDS-PAGE.
Target Names
Uniprot No.
Research Area
Alternative Names
Fgf20Fibroblast growth factor 20; FGF-20
Mus musculus (Mouse)
Expression Region
Target Protein Sequence
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
23.6 kDa
Protein Length
Full Length
Tag Info
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Tris-based buffer,50% glycerol
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

This Recombinant Mouse Fgf20 protein was made through genetic engineering. By putting the Fgf20 gene into the genetic material of E.coli cell, the E.coli could be used as factories or producers to make the desired Fgf20 protein for research uses. The expression region of this protein is at 1-211aa. No tag was used in the expression process. The purity is 85%+ determined by SDS-PAGE.

Fibroblast growth factor 20 (FGF20), a member of the FGF family, is a paracrine growth factor whose orthologs are highly conserved among vertebrates. Human FGF20 is highly similar to rat FGF20 and mouse FGF20 (nearly 95% amino acid identity). FGF20, expressed mainly in the brain, has been suggested to be a critical factor involved in brain development and neuronal homeostasis. Reports identified the therapeutic effects of FGF20 on CNS conditions, PD and Alzheimer's disease. According to a previous study, rhFGF20 protected against BBB disruption by suppressing the inflammatory response, an effect that might be mediated through inhibition of the JNK and NF-κB signaling pathways. aFGF has been reported to inhibit the activity of JNK and NFκB through TAK/TAB to exert anti-inflammatory effects, and FGF21 can inhibit the JNK/NFκB pathway. The positive roles of FGF20 in Parkinson’s disease (PD) imply that it may play a neuroprotective role in other CNS disorders.

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Target Background

Neurotrophic factor that regulates central nervous development and function.
Gene References into Functions
  1. Data show that Fibroblast Growth Factors (FGF) 9 and 20 regulate the number of cochlear progenitors. PMID: 25915623
  2. fibroblast growth factor 20 (Fgf20) is expressed in hair placodes and is induced by and functions downstream from epithelial ectodysplasin (Eda)/Edar and Wnt/beta-Catenin signaling to initiate formation of the underlying dermal condensation PMID: 23431057
  3. We hypothesized that Fgf20 plays a role in specification, amplification, or maintenance of Sox2 expression in prosensory progenitors of the developing mammalian cochlea. PMID: 22973011
  4. Fgf20 is a major downstream effector of ectodysplasin and affects ectodysplasin-regulated characteristics of tooth morphogenesis, including the number, size and shape of teeth. PMID: 22833125
  5. The data suggested that, at a minimum, Fgf9/20 and Bmp7 organize the nephron progenitor niche. FGF signaling likely regulates multiple important steps in the niche, including survival, proliferation, and competence. PMID: 22698282
  6. Data indicate that the viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans. PMID: 22235191
  7. expression of FGF20 in calvarial and limb development PMID: 11900978
  8. Fgf20 is expressed at the right time and place to mediate sensory cell specification and is the likely activator/ligand of fibroblast growth factor (FGF) receptor 1 during cochlear development. PMID: 18524904

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Subcellular Location
Protein Families
Heparin-binding growth factors family
Database Links
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