Recombinant Mouse Fibroblast growth factor 6(Fgf6)

Code CSB-YP008633MO
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Source Yeast
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Code CSB-EP008633MO
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Source E.coli
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Code CSB-EP008633MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP008633MO
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Source Baculovirus
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Code CSB-MP008633MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Fgf6
Uniprot No. P21658
Alternative Names Fgf6; Fgf-6; Hstf2Fibroblast growth factor 6; FGF-6; Heparin secretory-transforming protein 2; HST-2; HSTF-2; Heparin-binding growth factor 6; HBGF-6
Species Mus musculus (Mouse)
Expression Region 38-208
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

(From Uniprot)
Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.
Gene References into Functions
  1. A crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress. PMID: 21188410
  2. In the absence of FGF6, the mechanisms leading to myofibre hypertrophy were mediated specifically by an IGF-II/IGF2R signalling pathway distinct from the classic mechanism involving IGF-I and IGF1R. PMID: 15194422
  3. a role for FGF6 in the maintenance of a reserve pool of progenitor cells in the skeletal muscle PMID: 15389547
  4. At high doses, FGF6 stimulates the proliferation of the myogenic stem cells, whereas at lower doses it regulates both muscle differentiation and muscle phenotype via a calcineurin-signaling pathway. PMID: 15672378
  5. might be involved in the changes of secretory granule content of acinar cells in the sublingual gland during the late gestational and early neonatal stages PMID: 16617195
  6. Involvement of FGF6 in myogenesis. Review. PMID: 16875743
  7. Rescue experiments supported the idea of a specific relationship between FGF6 and Spry 2, both being known for their particular involvement in myogenesis. PMID: 18049951

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Subcellular Location Secreted, extracellular space
Protein Families Heparin-binding growth factors family
Tissue Specificity Embryos, adult muscles and adult testis.
Database Links

KEGG: mmu:14177

STRING: 10090.ENSMUSP00000000187

UniGene: Mm.3403


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