Recombinant Mouse Follistatin-related protein 1 (Fstl1)

1. Haploinsufficiency of Fstl1 in mice contributed to an exacerbated hypoxia-induced Pulmonary hypertension, as demonstrated by increased right ventricular systolic pressure, pulmonary arterial muscularization and right ventricular hypertrophy index PMID: 28361925
2. this study shows that FSTL-1 modulates IL-17 signaling via IL-17RC regulation in stromal cells PMID: 28377613
3. FSTL1 may exert its actions through the modulation of Akt signaling. PMID: 28765894
4. FSTL1 is a secreted osteoclastogenic factor that plays a critical role in osteoclast formation via the NF-kappaB and MAPKs signaling pathways. PMID: 27234130
5. study indicates a pivotal role for Fstl1 in early stage of lung airway smooth muscle development PMID: 28574994
6. This study reveals that Fstl1 is essential for the acute repair of the infarcted myocardium and that stimulation of early fibroblast activation is a novel function of Fstl1. PMID: 27234440
7. Deletion of Fstl1 from the endocardial/endothelial lineage results in deformed mitral valves, which cause regurgitation, heart failure, and early cardiac death. PMID: 28705792
8. A critical role for the Smad3-c-Jun pathway in the regulation of Fstl1. PMID: 28495857
9. FSTL1 may induce epithelial mesenchymal transition and airway remodeling by activating autophagy. PMID: 28473327
10. a new role for FSTL1 in the development of radial glial scaffolds and the neuronal migration of upper-layer projection neurons, is reported. PMID: 26382033
11. administration of Fstl1 induced airway remodeling and increased OSM, whereas administration of an anti-OSM Ab blocked the effect of Fstl1 on inducing airway remodeling, eosinophilic airway inflammation PMID: 26355153
12. epicardial cells contain a potent cardiogenic activity identified as follistatin-like 1 (Fstl1) PMID: 26375005
13. FSTL1 is a potent regulator of chondrocyte proliferation, differentiation and expression of extracellular matrix molecules. PMID: 24641944
14. muscle-derived Fstl1 attenuates neointimal formation in response to arterial injury by suppressing smooth muscle cell proliferation through an AMPK-dependent mechanism PMID: 24743592
15. functions in cardiorenal communication; lack of Fstl1 production by myocytes promotes glomerular and tubulointerstitial damage in the kidney PMID: 25071081
16. Fstl1 is induced in response to lung injury and promotes the accumulation of myofibroblasts and subsequent fibrosis. These data suggest that Fstl1 may serve as a novel therapeutic target for treatment of progressive lung fibrosis. PMID: 25584011
17. FSTL1 is elevated in various inflammatory conditions and decreased during the course of treatment. FSTL1 may therefore be a valuable biomarker for such diseases. PMID: 24838142
18. This study is the first to describe a role for FSTL-1 in the development of Lyme arthritis and anti-Borrelia response. PMID: 24768929
19. FSTL1 is a potential mediator of inflammation and insulin resistance in obesity. PMID: 24347831
20. These results suggest that FSTL-1 may act on the NLRP3 inflammasome to promote IL-1beta secretion from monocytes/macrophages. PMID: 24470197
21. preliminary X-ray crystallographic analysis of recombinant murine Follistatin-like 1 PMID: 23612079
22. identified FSTL1 as an independent prognostic biomarker in ACS. PMID: 22675198
23. Fstl1 is essential in maintaining normal ureter development by antagonizing BMP signaling. PMID: 22485132
24. FRP has the function of evoking innate immune responses as one of the endogenous TLR4 agonists. PMID: 22265692
25. Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload. PMID: 21987816
26. Fstl1 KO mice die at birth from respiratory distress and show multiple defects in lung development. Also, skeletal development is affected. PMID: 21826198
27. FSTL1-dependent activation of Na(+),K(+)-ATPase regulates the threshold of somatic sensation. PMID: 21382556
28. Fstl1 transgenic mice have improved glucose tolerance were resistant to high-fat diet-induced obesity and hepatic steatosis PMID: 21205933
29. reduction of Fstl1 expression sensitizes the kidney to acute cisplatin nephrotoxicity, suggesting a role for FSTL1-mediated Il-1beta suppression in protection of the kidney from acute nephrotoxic injury. PMID: 20861081
30. data suggest downregulation of Fstl1 expression may be an important feature of preadipocyte to adipocyte conversion PMID: 20043993
31. Studies show that Fstl1 is one of the mesenchymal factors determining oviductal epithelial cell fate. PMID: 20176958
32. These data indicate that DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. PMID: 20054002
33. Fstl1 expression is repressed by the microRNA miR-206. PMID: 17030984
34. In this study, developmental expression pattern of Fstl1 in the mouse was analyzed; Fstl1 is ubiquitously expressed in the early embryo, and that expression becomes regionalized later during development. PMID: 17129766
35. Fstl1 is a cardiac-secreted factor that functions as an antiapoptotic protein and may play a role in myocardial maintenance and repair in response to harmful stimuli. PMID: 18519848
36. Fstl1 is a secreted muscle protein or myokine that can function to promote endothelial cell function and stimulates revascularization in response to ischemic insult through its ability to activate Akt-eNOS signaling PMID: 18718903
37. Endogenous FSTL-1 can be induced by innate immune signals and plays a proinflammatory role in collagen-induced arthritis by enhancing T cell interferon-gamma production. PMID: 19109154

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KEGG: mmu:14314

STRING: 10090.ENSMUSP00000110411

UniGene: Mm.182434