Recombinant Mouse G protein-coupled receptor kinase 5 (Grk5)

1. Along with other supporting evidence, the authors propose that GRK5 deficiency selectively renders basal forebrain cholinergic neurons more vulnerable to degeneration. PMID: 27193825
2. Overall, these data suggest that GRK5 negatively regulates CXCL1/KC levels during bacterial pneumonia but that the role of GRK5 in the clinical outcome in this model is dependent on the bacterial dose. PMID: 26975990
3. Generated mice with genetic knockout (KO) of the G protein-coupled receptor kinase (GRK) 5 gene by microinjection of TALEN mRNA. TALEN vectors were designed to target exons 1, 3, and 5 of the mouse GRK5 gene. PMID: 27565865
4. These results of this study suggest that GRK5 deficiency indeed makes the mice more susceptible to wide range of behavioral impairments, including cognitive impairments. PMID: 26778781
5. MOR phosphorylation is regulated by agonist-selective recruitment of distinct GRK isoforms that influence different opioid-related behaviors. Modulation of GRK5 function could serve as a new approach for preventing addiction to opioids. PMID: 24629717
6. GRK5, acting in a kinase independent manner, is a facilitator of NFAT activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription. PMID: 25332207
7. influence of GRK5 on NF-kappaB expression and activity PMID: 24174526
8. regulator of inflammation and thymic apoptosis in polymicrobial sepsis PMID: 23485819
9. these data identified GRK5 as a positive regulator of insulin sensitivity. PMID: 23111327
10. metoprolol is a biased ligand that selectively activates a G protein-independent and GRK5/beta-arrestin2-dependent pathway, and induces cardiac fibrosis. PMID: 22888001
11. These results define myocyte GRK5 as a critical regulator of pathological cardiac growth after ventricular pressure overload, supporting its role as an endogenous (patho)-physiological HDAC kinase. PMID: 22859683
12. these results suggest that GRK5 is an important regulator of adipogenesis and is crucial for the development of diet-induced obesity. PMID: 22507984
13. GRK5 regulates IL-12p40 and G-CSF via a mechanism that is common to both MyD88 and TRIF. PMID: 22078319
14. G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. PMID: 22095977
15. GRK5 is a positive regulator of TLR4-induced IkappaBalpha-NFkappaB pathway as well as a key modulator of LPS-induced inflammatory response. PMID: 20945396
16. GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity PMID: 21041302
17. GRK5 as a novel kinase of p53, as well as a negative regulator of p53-mediated signal transduction. PMID: 20124405
18. Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling. PMID: 19801552
19. Results demonstrate that both GRK2 and GRK5 are important and novel mediators of a non-traditional IkappaBalpha/NF-kappaB signalling pathway. PMID: 19796012
20. GRK5 regulates pulmonary responses in a tissue- and receptor-specific manner but does not regulate peripheral cardiac muscarinic receptors. PMID: 14565944
21. in both male and female mice, vascular smooth muscle-specific overexpression of GRK5 elevates blood pressure mediated by Gi and by beta1AR in males and Ang II receptors in females PMID: 16103237
22. Taken together, these findings not only strongly support an important role of GRK5 deficiency in early Alzheimer's pathogenesis, but also promote the GRK5 knockout mouse as an additional model for early Alzheimer-related studies. PMID: 17011668
23. These results demonstrate previously unknown crucial regulatory mechanisms that alter ARR/GRK expression levels in macrophages that might modify many, if not all, GPCR-mediated innate immune responses. PMID: 18180038
24. GRK5 deficiency in vivo significantly exaggerates microgliosis and astrogliosis in the presence of an inflammatory initiator, such as the excess fibrillar Abeta and the subsequent active inflammatory reactions. PMID: 18522748
25. Data show that GRK5 knockout female mouse displays increased hippocampal axonal defects and synaptic degenerative changes. PMID: 18955119

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KEGG: mmu:14773

STRING: 10090.ENSMUSP00000003313

UniGene: Mm.279400