G protein-coupled receptor kinase 5 is a protein in humans that is encoded by GRK5 gene. Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates.
The following GRK5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
GRK5 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA009926GA01HU | GRK5 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA794868 | GRK5 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA002827 | GRK5 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA009926LA01HU | GRK5 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA009926LB01HU | GRK5 Antibody, HRP conjugated | Human | ELISA |
CSB-PA009926LC01HU | GRK5 Antibody, FITC conjugated | Human | |
CSB-PA009926LD01HU | GRK5 Antibody, Biotin conjugated | Human | ELISA |
GRK5 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP009926HU CSB-EP009926HU CSB-BP009926HU CSB-MP009926HU CSB-EP009926HU-B |
Recombinant Human G protein-coupled receptor kinase 5 (GRK5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GRK5 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP009926BO CSB-EP009926BO CSB-BP009926BO CSB-MP009926BO CSB-EP009926BO-B |
Recombinant Bovine G protein-coupled receptor kinase 5 (GRK5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GRK5 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP009926RA CSB-EP009926RA CSB-BP009926RA CSB-MP009926RA CSB-EP009926RA-B |
Recombinant Rat G protein-coupled receptor kinase 5 (Grk5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GRK5 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP009926MO CSB-EP009926MO CSB-BP009926MO CSB-MP009926MO CSB-EP009926MO-B |
Recombinant Mouse G protein-coupled receptor kinase 5 (Grk5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |