Recombinant Mouse GRB2-associated-binding protein 1 (Gab1)

1. Conditional Gab1 knockout mice showed general retardation in muscular growth and hypotrophy of extrafusal muscle fibers. Muscle-specific Gab1 knockout mutant exhibited significant underdevelopment of muscle spindles, which are normally regulated by NRG1, and abnormal proprioceptive behavior. Selective knockdown of Gab1 in C2C12 muscle cells reduced NRG1-induced expression of Egr3. PMID: 28542067
2. Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r, synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r = interleukin-4 receptor) PMID: 28687632
3. these findings suggest that the striated muscle-specific high-MW isoform of Gab1 has a crucial role for NRG-1/ErbB signaling in cardiomyocytes. PMID: 27861634
4. These findings provide the direct evidence about the roles of docking protein Gab1 in lungs. PMID: 27793798
5. These results demonstrate that cardiomyocyte Gab1 is a critical regulator of the compensatory cardiac response to aging and hemodynamic stress. PMID: 26517531
6. Gab1 is essential regulator of the hair cycle and the self-renewal of hair follicle stem cells. PMID: 26456821
7. Hepatocyte Gab1 is required for liver fibrosis and that hepatocyte CCL5 could be an important contributor to this process. PMID: 25617348
8. endothelial Gab1 signaling inhibited splenomegaly in portal hypertension independent of angiogenesis. PMID: 25501549
9. Suggest that Gab1 is essential for cardioprotection against ischemia reperfusion oxidative injury, mediating survival signaling. PMID: 24951957
10. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development PMID: 24284065
11. endothelial Gab1 deletion accelerates AngII-dependent vascular inflammation and atherosclerosis on ApoE-null background presumably in association with downregulation of KLF2 and KLF4. PMID: 22664868
12. The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 and PAR3. PMID: 22883624
13. Gab1 is essential for postnatal angiogenesis through mediating angiogenic and survival signaling. PMID: 21372298
14. PECAM-1-mediated inhibition of GPVI-dependent platelet responses result from recruitment of SHP-2-p85 complexes to tyrosine-phosphorylated PECAM-1, which diminishes the association of PI3K with activatory signaling molecules Gab1 and LAT PMID: 20723025
15. in myeloid cells, Gab1 is likely to enhance HGF mitogenicity by coupling Met to Shp-2 and GATA-2 expression, thereby potentially contributing to normal myeloid differentiation as well as oncogenic transformation PMID: 20506405
16. These data show that a Gab1-Nck signalling complex interacts with several receptor tyrosine kinases to promote polarised actin remodelling and downstream biological responses. PMID: 20332103
17. Gab1 is needed for full activation of TLR3/4- and RIG-I-triggered innate responses by promoting activation of PI3K/Akt, MAPKs, and NF-kappaB pathways PMID: 20435932
18. Results show that Gab1-mediated signals in osteoblasts are crucial for normal postnatal bone homeostasis. PMID: 20124419
19. comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat PMID: 11701952
20. Gab1 is a unique negative regulator of the thymus-independent antigen-2 response specifically expressed in splenic marginal zone B cells. PMID: 11994464
21. distinct recruitment and function in Met receptor-mediated epithelial morphogenesis PMID: 12058075
22. Gab1 is an integrator of cell death versus cell survival signals in oxidative stress PMID: 12808090
23. Gab1-deficient mouse fibroblast cells were defective in induction of JNK activity by UV exposure or heat shock PMID: 14749370
24. Gab1 plays a selective role in the regulation of the mitogen-activated protein kinases Erk and p38 downstream of the PDGF beta-receptor, and contributes to cytoskeletal reorganization and chemotaxis in response to PDGF PMID: 14973141
25. coupling of Gab1 to PI3K is important for biological responses in RET-expressing cells PMID: 15351743
26. Gab1 acts to attenuate, through promotion of the Erk pathway, insulin-elicited signals flowing through IRS and Akt proteins, which represents a novel balancing mechanism for control of insulin signal strength in the liver. PMID: 15821749
27. Gab1 and Cxcr4 cooperate to control the development of migrating muscle stem cells. PMID: 16166380
28. shear stress-induced activation of eNOS depends on Gab1 and SHP2, which, in turn, regulate the phosphorylation and activity of eNOS by a PKA-dependent but Akt-independent mechanism. PMID: 16284184
29. physiological significance of the Gab1/Shp2 link in promoting mitogenic signaling through the Erk pathway in liver regeneration PMID: 16738330
30. This study provides the first evidence that Gab1 is a key binding partner of the Met receptor for induction of cell cycle progression, proliferation, and oncogenic morphological transformation. PMID: 16775003
31. These results underscore the non-redundant and essential roles of Gab1 and Gab2 in endothelial cells, and suggest major contributions of these proteins during in vivo angiogenesis. PMID: 19233262

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KEGG: mmu:14388

STRING: 10090.ENSMUSP00000034150

UniGene: Mm.277409