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Recombinant Mouse GTP-binding protein REM 1 (Rem1)

Recombinant Mouse GTP-binding protein REM 1 (Rem1)

Code	CSB-YP019559MO
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Yeast
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Code	CSB-EP019559MO
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
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Code	CSB-EP019559MO-B
MSDS	MSDS Datasheet
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP019559MO
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP019559MO
MSDS	MSDS Datasheet
Size	Pls inquire
Source	Mammalian cell
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Rem1

Uniprot No.

O35929

Alternative Names

Rem1; Rem; GTP-binding protein REM 1; Rad and Gem-like GTP-binding protein 1

Species

Mus musculus (Mouse)

Expression Region

1-297

Target Protein Sequence

MTLNTQQEAK TTLRRRASTP LPLSSRGHQP GRLCTAPSAP SQHPRLGQSV SLNPPVRKPS PAQDGWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF AEKQDRDPHE QLGGVYERTL SVDGEDTTLV VMDTWEAEKL DESWCQESCL QAGSAYVIVY SIADRSSFES ASELRIQLRR THQANHVPII LVGNKADLAR CREVSVEEGR ACAVVFDCKF IETSATLQHN VTELFEGVVR QLRLRRQDNA APETPSPRRR ASLGQRARRF LARLTARSAR RRALKARSKS CHNLAVL

Protein Length

Full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function

Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.

Gene References into Functions

These results reveal that similar molecular determinants on Rem are repurposed to initiate 2 independent mechanisms of CaV1.2 inhibition. PMID: 27115600
Rad, Gem and Rem all reduce depolarization-dependent Ca2+ entry in developing myotubes. PMID: 24476902
amino-termini of Rad and Rem as the structural elements dictating the specific modes of inhibition of CaV1.1 PMID: 24806927
Loss of an REM1 protein increased L-type calcium current density in vivo in cardiac myocytes. PMID: 22854599
both Rem and Rad bind directly to Ca2+ channel beta-subunits (CaV beta) in vivo PMID: 14623965
We conclude that Rem is capable of regulating L-type current, that release of Rem block is modulated by cellular kinase pathways, and that the Ca(V)1.2 COOH terminus contributes to Rem-dependent channel inhibition. PMID: 16648185
Rem-dependent Ca2+ channel modulation involves formation of a Rem x CaVbeta x alpha-interaction domain regulatory complex without the need to disrupt CaValpha1 x CaVbeta association or alter CaValpha1 expression at the plasma membrane. PMID: 16790445
Nuclear localization of RGK proteins (Rad, Rem, and Rem2) contributes to the suppression of RGK-mediated cell shape remodeling. PMID: 17605760
a role for the Rem C terminus in plasma membrane localization through association with phosphatidylinositol lipids. PMID: 17686775