Recombinant Mouse Gamma-aminobutyric acid type B receptor subunit 1 (Gabbr1), partial

1. These data suggest that GABA, acting through both presynaptic GABAA and GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result not possible from activation of either receptor type alone PMID: 27061582
2. presynaptic gamma-aminobutyric acid type B receptor deficits contribute to altered neuronal excitability in fragile X syndrome PMID: 28213518
3. This study showed that increase dorsal raphe GABA(B1a) expression via epigenetic regulation is associated with abnormal responses to social stimulation such as encounter-induced hyperactivity and aggressive behavior in isolation-reared mice PMID: 26365570
4. activation of presynaptic hippocampal GABAB receptors is important for acquisition of a learning task and for learning-associated synaptic changes and network dynamics. PMID: 26848590
5. These results suggest a role for GABAB receptor in Fmrp regulation and a potential interest of GABAB receptor signaling in Fragile X syndrome improvement. PMID: 26020477
6. Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2+) transients and striatal field potentials. PMID: 25781000
7. Embryonic GABA-B receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice. PMID: 25162235
8. Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 and GABABR2 at both protein and mRNA levels in the CNC PMID: 25592416
9. Results show GABA(B(1a,2)) and GABA(B(1b,2)) receptor subtypes differentially modulate Granule Cell outputs via selective axonal terminal and dendritic locations in the hilar pathways. PMID: 23186302
10. GABAB(1) receptor subunit isoforms differentially regulate the deleterious effects of stress and, thus, may be important therapeutic targets for the treatment of depression PMID: 25288769
11. Results establish an endogenous GABA/GABAB1 feedback mechanism that keeps TRPV1-mediated pain hypersensitivity in check. PMID: 25679765
12. The Gabbr1 has an important role in mediating the anxiety-related effects induced by nicotine. PMID: 24486711
13. The results of this study suggested a complex role for GABAB receptors in mediating neocortical circuit function. PMID: 24873729
14. Results show that GABAB(1a) receptors are required for the maintenance, but not encoding, of a precise fear memory; and are required for the maintenance, but not encoding, of spatial memories PMID: 24634352
15. The study suggested that the altered pain sensitivity derives from a Schwann cell-specific loss of GABA-B receptor functions, pointing to a role for GABA-B receptors in the regulation of Schwann cell maturation towards the non-myelinating phenotype. PMID: 24474699
16. Sex differences in reproductive genes Gnrh1, Gad1, and Kiss1 are critically disturbed in GABAB1-deficient mice, probably altering the organization and development of neural circuits governing the reproductive axis. PMID: 24080944
17. GABAB signaling may normally directly or indirectly inhibit Kiss1 expression, particularly in the bed nucleus of the stria terminalis and medial amygdala PMID: 24424047
18. Pharmacological inhibition of GABAB receptors stimulated neural stem cell proliferation and genetic deletion of GABAB1 receptor subunits increased neural stem cell proliferation and differentiation of neuroblasts in vivo. PMID: 24284211
19. Enhanced GABA B receptor activity reduces expression of Arg3.1, which is critical for long-term memory. PMID: 24431439
20. These data indicate that stimulation of GABAergic neurons with the GABAB receptor agonist, baclofen, enhances ubiquitin-proteasome system (UPS) function and cell survival in in vitro and in vivo models of HD. PMID: 24333873
21. Deletion of GABAB1 receptors in proopiomelanocortin neurons in the male mice on a high fat diet results in obesity, insulin resistance, and hypothalamic inflammation. PMID: 24155320
22. Cell type-specific up-regulation of GABA(B)R-mediated autoinhibition in CCK(+) basket cells promotes aberrant high frequency oscillations and hyperexcitability in hippocampal networks in chronic epilepsy. PMID: 23980149
23. siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1. PMID: 23829864
24. These results suggest that presynaptic GABAB receptors contribute to spontaneous DOWN state transitions, and postsynaptic GABAB receptors are essential for afferent termination of the UP state. PMID: 23266934
25. data indicate that PP2A dephosphorylates GABA(B)R2(S783) less efficiently than AMPK(T172), and that additional phosphatases might be involved in S783 dephosphorylation PMID: 23238131
26. Glucose metabolism and energy balance disruptions were more pronounced in GABAB1KO males, which develop peripheral insulin resistance probably due to augmented insulin secretion. PMID: 23178152
27. The transport of axonal GABA(B)R1a is microtubule-dependent and kinesin-1, a molecular motor of the kinesin family, determines axonal localization. PMID: 22952914
28. investigation of role of GABA receptor B subunit 1 (GABABR1) in acute and chronic responses to nicotine; studies include knockout mice lacking GABABR1 and role of GABABR1 in nicotine withdrawal syndrome (induced by nicotinic antagonist) PMID: 22727822
29. Gabbr1 and Gabbr2 transcription levels were altered in cerebral areas related to drug taking only in mice behaviorally classified as "addicted" drinkers PMID: 22579910
30. RyR-1 and -2 expression facilitated by D1DR stimulation are negatively regulated by GABA(B) receptor via suppression of cAMP production. PMID: 22504960
31. activation increases the energy barrier for vesicle fusion PMID: 21852427
32. Data show that L. rhamnosus (JB-1) induced region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus. PMID: 21876150
33. GABA(B)R is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 expression toward disturbance of osteoclastogenesis after down-regulation of RANKL expression in mouse bone. PMID: 21828041
34. This immunohistochemical (IHC) analysis revealed increased levels of CRH in the PVN of newborn mice lacking functional GABA(B) receptors. PMID: 21236282
35. Results indicate that GABA(B)R1 subunit is constitutively expressed by adipocytes to primarily regulate leptin expression at the transcriptional level. PMID: 21655283
36. The heterodimeric GABA(B) receptor can form higher-ordered oligomers in the brain, as suggested by the close proximity of the GABA (B1) subunits. PMID: 21552208
37. results suggest that GABA(B)R2 protein levels are closely correlated with the partner subunit GABA(B)R1 protein levels in mouse brains during postnatal development in vivo PMID: 21160134
38. This study shows a possible mechanistic link between maternal epilepsy induced neurodegeneration alteration of GABAB1R and PKA expression level during prenatal brain development. PMID: 19545402
39. NMDA-dependent S867 phosphorylation and internalization is predominantly detectable with the GABAB1b subunit isoform, which is the isoform that clusters with inhibitory effector K+ channels in the spines. PMID: 20643921
40. The betagamma subunits produced by the Gi-coupled GABA(B) receptor enhance the mGlu1a-mediated Gq response.[mGlu1a] PMID: 19590495
41. MPTP-induced denervation is associated with a decrease of GABA(B) receptors restricted to the substantia nigra pars compacta PMID: 11304760
42. Functional GABA(B) receptors expressed in cultured calvarial osteoblasts PMID: 12054677
43. results suggest that GABA(B) receptors regulate the constipating effect of gamma-hydroxybutyric acid and NCS-382 PMID: 12138019
44. As in the central nervous system, the GABA(B1) receptor subunit is an essential requirement for GABA(B) receptor function in the enteric and peripheral nervous systems. PMID: 12452899
45. Our data suggest that association of GABAB(2) with GABAB(1) is essential for receptor localization in distal processes but not absolutely necessary for signaling. Functional GABAB receptors may exist in neurons that naturally lack GABAB(2) subunits. PMID: 15240800
46. identification of the minimal functional domain which still binds a competitive radioligand and leads to a functional, GABA-responding receptor when co-expressed with GABA(B2) PMID: 15482257
47. Conservation of GABABR1 micro-exon 4 across species suggests a conserved functional role, facilitating either N-terminal protein production or post-transcriptional gene regulation through regulated splicing coupled to transcript decay. PMID: 15968089
48. GABA(B) receptors appear to be involved in hippocampal CA3 pyramidal cell death induced by kainic acid administered i.c.v. in mice. PMID: 16391514
49. Loss of GABAB activity results in a sustained moderate hyperdopaminergic state, which is phenotypically revealed by contextual hyperlocomotor activity. PMID: 16606363
50. A high degree of coclustering of Kir3.2 and GABA(B1) receptor is revealed around excitatory synapses PMID: 16624949

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KEGG: mmu:54393

STRING: 10090.ENSMUSP00000025338

UniGene: Mm.32191