Recombinant Mouse Gamma-aminobutyric acid type B receptor subunit 2 (Gabbr2), partial

1. Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma but decreased that of GABABR1 and GABABR2 at both protein and mRNA levels in the CNC PMID: 25592416
2. GABABR2 has a role as a regulator of glutamine synthetase stability PMID: 25172509
3. siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1. PMID: 23829864
4. Cadm1 specifically interacts with Mupp1, and may form a ternary complex with Mupp1-GABBR2 in the cerebellum. PMID: 22994563
5. Gabbr1 and Gabbr2 transcription levels were altered in cerebral areas related to drug taking only in mice behaviorally classified as "addicted" drinkers PMID: 22579910
6. GABA(B)R is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 expression toward disturbance of osteoclastogenesis after down-regulation of RANKL expression in mouse bone. PMID: 21828041
7. results suggest that GABA(B)R2 protein levels are closely correlated with the partner subunit GABA(B)R1 protein levels in mouse brains during postnatal development in vivo PMID: 21160134
8. GABA(B) receptors are abundantly expressed on the vestibulospinal neurons of Deiters in mice. They contribute to the compensation of static vestibular reflexes following unilateral peripheral damage. PMID: 20394801
9. Our data suggest that association of GABAB(2) with GABAB(1) is essential for receptor localization in distal processes but not absolutely necessary for signaling. Functional GABAB receptors may exist in neurons that naturally lack GABAB(2) subunits. PMID: 15240800
10. heterodimeric GABAB(2) receptors are required for the normal regulation of emotional behaviour. PMID: 15706241
11. postsynaptic, and perhaps presynaptic, GABAB receptors may be expressed at GABAergic synapses between dendrites of periglomerular interneurons and projection neurons. PMID: 16714082
12. The presence of GABA(B)Rs in developing oligodendrocytes provides a new mechanism for neuronal-glial interactions during development and may offer a novel target for promoting remyelination following white matter injury. PMID: 17144904
13. Endogenous modulation of respiratory rhythm by GABA(B)-receptorsis mediated through activation of an inwardly rectifying potassium channel.conductance PMID: 17428748
14. Activation of GABA(B) receptor by either GABA or the selective agonist baclofen induces ERK(1/2) phosphorylation in cultured cerebellar granule neurons. PMID: 17582742
15. Postsynaptic GABA(B) receptors activated GIRK current and would further modulate the activity of FCs. PMID: 18190780
16. GABABR2 are expressed in the cerebellar cortex, supporting previous studies showing that inhibitory neurotransmission is highly patterned in the cerebellar cortex. PMID: 18418671
17. GABA B heteroreceptors regulating glutamate release are predominantly, but not exclusively composed of GABA B(1a) and GABA B(2) subunits PMID: 18665320

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KEGG: mmu:242425

STRING: 10090.ENSMUSP00000103378

UniGene: Mm.101909