Recombinant Mouse Glutamate receptor ionotropic, NMDA 2A (Grin2a), partial

1. GluN2A knockout mice did not exhibit increases in ethanol drinking or alterations in Ro 25-6981 mediated alteration of decay kinetics of NMDAR-mediated synaptic transmission following chronic intermittent ethanol vapor exposure. PMID: 29953905
2. Study indicates that a lack of GluN2A-containing NMDARs alters the fine control of redox status, leading to a delayed maturation of perineuronal nets, and conferring vulnerability for long-term oxidative stress, microglial activation, and parvalbumin interneurons network dysfunction. PMID: 29024713
3. this study reveals an unexpected role of glycine in eliciting a non-ionotropic activity of GluN2ARs to confer neuroprotection via Akt activation. PMID: 27694970
4. Results show the coupling of GluN subunit 2A with interacting proteins, particularly postsynaptic density-95 (PSD95) is modulated by CIN. PMID: 27212638
5. activity-based anorexia resilience, quantified as suppression of hyperactivity, correlated strongly with reserve pools of NR2A-NMDA receptors in spine cytoplasm PMID: 27915379
6. Drebrin A can be found co-clustering with NR2B-containing NMDARs at the plasma membrane, while NR2A-containing NMDARs co-traffic into the spine cytoplasm but do not co-cluster at the plasma membrane. PMID: 28865018
7. This study demonstrated that Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace. PMID: 27605622
8. Grin2aPKC mice exhibit reduced anxiety in the open field test, light dark emergence test, and elevated plus maze. Overall, these results suggest that at least one of those PKC-mediated phosphorylation sites regulates NMDAR-mediated signaling that modulates anxiety. PMID: 27317637
9. These data suggest that chronic early postnatal SSS influences spatial learning and memory ability, levels of hippocampal NR2B, and NR2A/NR2B ratios in adult males. PMID: 27015584
10. Study demonstrated that GluN2A carboxy-terminal domain is responsible for the impaired long-term olfactory and social memory observed in the GluN2A overexpression mice PMID: 26179233
11. Results establish the GluN2A subunit as a significant contributor to both bidirectional synaptic plasticity and spatial pattern separation in the dentate gyrus PMID: 24554729
12. Best1-mediated astrocytic glutamate activates the synaptic N-methyl-D-aspartate receptor (NMDAR) and modulates NMDAR-dependent synaptic plasticity. PMID: 25645137
13. Data suggest a role for GluN2A in ethanol tolerance. PMID: 24397780
14. We conclude that TSPYL2 contributes to cognitive variability through regulating the expression of Grin2a and Grin2b. PMID: 24413569
15. Results suggest that GluN2B is essential for the survival of animals, and that the GluN2B-GluN2A switching plays a critical role in synaptic integration of AMPARs through regulation of GluA1 in the whole animal. PMID: 25131300
16. GluN2A KO mice showed a specific and significant impairment in ventromedial prefrontal cortex-mediated set-shifting. PMID: 25059550
17. Deletion of the NMDA receptor GluN2A subunit significantly decreases dendritic growth in maturing dentate granule neurons. PMID: 25083703
18. data suggest that basal, but not evoked, N-MethylD-apartate Receptor activity regulates gene expression in part through Histone Deacetylase 4, and, that HDAC4 has neuroprotective functions under conditions of low NMDAR activity. PMID: 25392500
19. A single amino acid substitution (N595Q) in the GluN2A subunit of the NMDA receptor, specifically in the hippocampal dentate gyrus in mice, reduced the Mg2+ block at the medial perforant path-granule cell synapse. PMID: 24893573
20. These findings (a) indicate novel, differential roles for GluN2A, B and D receptors and for GAD65-mediated GABA in the regulation of individual topographies of orofacial movement PMID: 23892010
21. Data indicate that ablation of agouti-related protein (AgRP) neurons results in enhanced expression of NR2B along with a modest suppression of NR2A. PMID: 23964123
22. NR2A-containing NMDAR inhibition as well as NR2A-subunit knockout diminished dendritic spine loss but not the Abeta effect on hTau. PMID: 23618906
23. These data suggest distinct roles of the GluN2A subunit as whole vs. its intracellular domain in modulating anxiety and depression-like symptoms and reveal differential molecular targets for the therapy of mood and anxiety disorders. PMID: 23557693
24. In Mecp2 knockout mice, both cortical function and inhibitory hyperconnectivity were strikingly rescued independent of Mecp2 by early sensory deprivation or genetic deletion of the excitatory NMDA receptor subunit, NR2A. PMID: 23259945
25. The data of this study indicated that vertebrate behavior and synaptic signaling acquired increased complexity from the duplication and diversification of ancestral GluN2a and GLUN2b genes. PMID: 23201971
26. NR2AR-PTEN-TDP-43 signaling pathway is revealed by which nuclear TDP-43 promotes neuronal survival. PMID: 22526419
27. No differences in expression of NR2A, NR2C or NR2D are found in any brain region examined during ethanol consumption and acute ethanol withdrawal. PMID: 21945132
28. The increase in GluN2A-containing receptors between PND 4-6 and 14-16 and the reduction in Pr may contribute to the developmental transition in hippocampal plasticity from long-term depression to long-term potentiation PMID: 22351628
29. NR2A and NR2B subunits play different roles in motor neuron chronic glutamate excitotoxicity in amyotrophic lateral sclerosis. PMID: 21503117
30. Inhibition of the GluN2A subtype reduces long term potentiation to the same level in NCAM-deficient and wild-type (NCAM-positive) littermate mice and abolishes the rescue by d-cycloserine in NCAM-deficient mice. PMID: 22396402
31. Changes in molecular composition support an important role of NR2A subunits in the developmental plasticity of fast-spiking GABAergic circuits during critical period. PMID: 20936660
32. Data show that both GluN2B and GluN2A suppress AMPA receptor expression, albeit by distinct means. PMID: 21943605
33. Retrosplenial cortex-dependent context fear memory retrieval is mediated by NR2A (not NR2B) subunit-containing NMDA receptors. PMID: 21832195
34. presymptomatic mice in an ALS mouse model exhibit a selective decrease of NR2A subunit expression PMID: 20732897
35. NMDA-NR2A mediated potentiation at the mossy fiber to granule cell synapse is not required for basic motor performance PMID: 21185357
36. The discrete contribution of synaptic and total NR2A- and NR2B-containing NMDAR to nuclear transmission vs. membrane retention of ERK kinase signaling may underlie their specific roles in the formation of contextual and trace fear memory. PMID: 19806658
37. dysbindin controls hippocampal LTP by selective regulation of the surface expression of NR2A PMID: 19955431
38. The transfected NR2A subunit localizes in dendritic structures and determines the decay of NMDA-mediated miniature spontaneous excitatory postsynaptic currents in transfected hippocampal neurons. PMID: 11897109
39. Regulated appearance of NMDA receptor subunits and channel functions during in vitro neuronal differentiation. PMID: 11920728
40. GluR epsilon 1 mRNA expression is fundamental to the developing motoneurons of the embryonic hypoglossal nucleus. PMID: 12103442
41. KIF17 contributes to neuronal events required for learning and memory by trafficking fundamental N-methyl-d-aspartate-type glutamate receptor, NR2A. PMID: 12391294
42. NR2A has a role in targeting of PSD-95 to the postsynaptic density in developing synapses PMID: 12552130
43. During postnatal development, absence of brain derived neurotrophic factor induces a reduction of NR2A (but not NR2B) receptor level in visual cortex. PMID: 12735629
44. GluRepsilon1 has locus-specific roles in the development of morphine analgesic tolerance and physical dependence PMID: 12878694
45. Hippocampal neurogenesis is enhanced when wild-type mice are raised in cages with running wheels for 3 weeks, but the wheel exercise does not enhance the neurogenesis in mice lacking the NMDA receptor epsilon 1 subunit. PMID: 12941447
46. We investigated behavioural adaptations to addictive drugs such as phencyclidine, methamphetamine and morphine in mice lacking NMDA receptor GluRepsilon1 subunit; our findings evidence that GluRepsilon1 subunit receptors are involved in drug addiction PMID: 14750973
47. Expression of GluRepsilon 1 is essential for postsynaptic localization and protein stability of the GluRzeta1 subunit. PMID: 15317856
48. mutant mice lacking the N-methyl-D-aspartate receptor GluRepsilon1 subunit were more resistant to ketamine than control mice PMID: 15385364
49. Cerebellar NR2A receptor is important for proper motor coordination and cannot be replaced by long-term expression of the NR2B receptor during cerebellar granule cell maturation. PMID: 15519237
50. The PDZ (PSD-95, discs large, zona occludens-1) binding motif at the distal end of the NR2 C-terminal tail is critical to the actions of PSD-95 on NMDAR function and surface expression. PMID: 15537884

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KEGG: mmu:14811

STRING: 10090.ENSMUSP00000032331

UniGene: Mm.2953