Recombinant Mouse Glutathione peroxidase 2(Gpx2)

Code CSB-YP872823MO
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Source Yeast
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Code CSB-EP872823MO
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Source E.coli
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Code CSB-EP872823MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP872823MO
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Source Baculovirus
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Code CSB-MP872823MO
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Gpx2Glutathione peroxidase 2; GPx-2; GSHPx-2; EC; Glutathione peroxidase-gastrointestinal; GPx-GI; GSHPx-GI
Mus musculus (Mouse)
Expression Region
Target Protein Sequence
Protein Length
full length protein
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Gene References into Functions
  1. High glutathione peroxidase 2 expression is associated with radiation induced lung disease. PMID: 25150064
  2. we propose that ileocolitis in the GPx1/2-double-knockout mice is caused by Nox1, which is induced by TNF PMID: 24374371
  3. GPx2 is up-regulated in dysplastic colonic crypts, where it appears to act inhibit apoptosis and, thus, supports tumor development. PMID: 23977205
  4. it is concluded that GPx2, although supporting tumor growth, inhibits inflammation-mediated tumorigenesis, but the protective effect of selenium does not strictly depend on GPx2 expression PMID: 22180572
  5. study indicates GI-GPx is spatiotemporally expressed in embryonic organs during organogenesis and may also perform a mutual compensatory role with cGPx in protecting embryos and extraembryonic tissues against reactive oxygen species PMID: 21323725
  6. Loss of Gpx2 is associated with diet induced severe colitis. PMID: 20848490
  7. Genes encoding the antioxidants GPX2 and GSTO 1-1 are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility. PMID: 19897562
  8. A trace amount of Gpx2 is protective against ileocolitis, and selenium and Gpx2 deficient mice will develop pathology similar to normal mice. PMID: 15795427
  9. Glutathione peroxidase 2 (GPX2) is the major oxidative stress-inducible cellular GPX isoform in the lungs, and its basal as well as inducible expression is dependent on Nrf2. PMID: 16794261
  10. GPX2 activity is confined to the mucosal epithelium of the GI tract. Activity is detected all along the crypt-villus axis with concentration in the crypts. GPX1 activity is found in all layers of the gut and all parts of the mucosal epithelium. PMID: 9685647
  11. Mice homozygous for combined targeted mutations of the Gpx1 and Gpx2 genes develop colitis at 11 days of age and ileitis by 21 days of age. This suggests that glutathione peroxidases function to prevent inflammation in the GI tract. PMID: 11518697
  12. In the presence of normal microflora, mice deficient in Gpx1 and Gpx2 by targeted mutation develop ileocolitis at weaning. In the germfree state the mice display no GI tract pathology. PMID: 12751789

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Subcellular Location
Protein Families
Glutathione peroxidase family
Database Links
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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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