Recombinant Mouse Growth arrest and DNA damage-inducible protein GADD45 beta (Gadd45b)

1. Results indicate a role for Gadd45b in stress-induced senescence and in tissue aging. PMID: 27105496
2. Using whole-body knockout mice as well as liver/hepatocyte-specific gain- and loss-of-function strategies, the authors revealed a role for liver GADD45beta in the coordination of liver fatty acid uptake, through cytoplasmic retention of FABP1, ultimately impacting obesity-driven hyperglycaemia. PMID: 27137487
3. This study indicates that PPAR alpha activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver and that epigenetic change at the Gadd45b promoter is critical for Gadd45b induction. PMID: 27233605
4. Data suggest that the increased expression of Gadd45beta induced by repeated administration of L-DOPA may be beneficial in patients with Parkinson's disease. PMID: 26875664
5. lower nucleus accumbens levels may affect Bdnf expression possibly leading to altered alcohol-drinking behavior PMID: 26842245
6. Gadd45b mediates the action of electroconvulsive shock-induced neural stem cell proliferation in the hippocampus. PMID: 26281755
7. Results suggest the possibility that differential Gadd45a, Gadd45b and Gadd45g expression during development affects neurons, contributing cortical evolution and diversity PMID: 25450958
8. Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3. PMID: 23939942
9. Modulation of the TGFbeta/NFkappaB/Gadd45b signaling pathway may provide a means to enhance the neuroprotective effect of Gadd45b in RGCs. PMID: 23329662
10. These results implicate Gadd45b as a learning-induced gene and a regulator of memory formation and are consistent with its potential role in active DNA demethylation in memory. PMID: 23197699
11. The data suggest that GADD45beta plays a complex role in regulating adaptive immunity and, depending on the model, either enhances or suppresses inflammation. PMID: 21702006
12. The current studies suggest that Gadd45b may be important for long-term hippocampus-dependent memory storage. PMID: 22802593
13. these data highlight a novel role for both Gadd45a and Gadd45b in myeloid innate immune functions by differential modulation of p38 and JNK signaling in granulocytes compared to macrophages. PMID: 22307729
14. Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development. PMID: 21843656
15. defined separate Gadd45beta domains that mediated binding to CAR and transcriptional activation PMID: 21965327
16. The synergism between GADD45beta and C/EBPbeta may play an important role in cellular senescence in the aging articular cartilage. PMID: 21353395
17. Gadd45b was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions. PMID: 20938992
18. CAR may repress death of mouse primary hepatocytes by forming a GADD45B complex and repressing MKK7-mediated phosphorylation of JNK1 PMID: 20404936
19. Findings suggest that Gadd45b mediates p38-induced Rb phosphorylation by enhancing the interaction between p38 and Rb during Fas-induced apoptosis in murine hepatocytes. PMID: 20558744
20. we have uncovered a novel molecular mechanism linking GADD45beta via the MTK1/MKK3/6/p38 axis to C/EBPbeta-TAD4 activation of Col10a1 transcription in terminally differentiating chondrocytes PMID: 20048163
21. members of the Gadd45 gene family are important for anti-tumor immune responses. PMID: 19688743
22. GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. PMID: 12124778
23. participation of NF-kappaB in the regulation of Gadd45beta PMID: 12162804
24. are induced by acute hypertonicity in murine kidney collecting duct cells. PMID: 12372778
25. gadd45b deletion doesn't affect TNF-alpha nor cell survival PMID: 12917673
26. GADD45b participates in TGF-beta-induced apoptosis by acting upstream of p38 activation PMID: 12933797
27. Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells. PMID: 14691480
28. Results identify MKK7/JNKK2 as a target of Gadd45 beta. PMID: 14743220
29. During Th1 differentiation, the GADD45beta/GADD45gamma/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12/STAT4, leading to augmented interferon-gamma production in a process independent of STAT4. PMID: 15044949
30. Gadd45alpha/beta induction transiently increases early caspase 3/7 and annexin V binding but inhibits later stages of apoptosis during severe hyperosmolality PMID: 15262964
31. NF-kappaB signaling involves induction of GADD45beta expression, which has a role in protecting cells against DNA damaged under various stress conditions PMID: 15797874
32. Hematopoietic cells from Gadd45b-deficient mice are sensitized to genotoxic-stress-induced-apoptosis. PMID: 16170381
33. In the liver, Gadd45 can be induced by a distinctive pathway that requires constitutive androstane receptor and is independent of TNF-alpha-nuclear factor B. PMID: 16231353
34. Gadd45beta plays a critical role in the resolution of immune responses that prevent autoimmunity PMID: 16287712
35. in hematopoietic cells exposed to UV radiation Gaddd45a and Gadd45b cooperate to promote cell survival via two distinct signaling pathways PMID: 16636063
36. data indicate that both gadd45a and gadd45b play a role in modulating physiological stress responses of myeloid cells to acute stimulation with differentiating cytokines, myelo-ablation and inflammation PMID: 16732331
37. Datas show that immunization of mice with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45beta. PMID: 16826163
38. Gadd45 is an oncogenic pro-survival factor; overexpression of Gadd45 transforms NIH3T3 mouse fibroblasts and supports tumorigenesis. PMID: 17891184
39. GADD45B, acting as a CAR coactivator and coregulating CAR target genes, may be involved in hepatic drug metabolism and excretion of xenobiotics PMID: 18362160
40. These data provide a basis for JNK suppression during liver regeneration and identify Gadd45beta as a potential therapeutic target in liver diseases. PMID: 18382767
41. Gadd45b is upregulated in retinal ganglion cells in response to oxidative stress and aging, and protects retinal ganglion cells from dying against oxidative stress in vivo in Gadd45b knockout mice. PMID: 18977442
42. study identifes Gadd45b as a neural activity-induced immediate early gene in mature hippocampal neurons; Gadd45b is required for activity-induced DNA demethylation of specific promoters and expression of corresponding genes critical for adult neurogenesis PMID: 19119186
43. Deficient Gadd45beta expression in RA can contribute to activation of JNK, exacerbate clinical arthritis, and augment joint destruction. PMID: 19877043

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KEGG: mmu:17873

STRING: 10090.ENSMUSP00000015456

UniGene: Mm.1360