Recombinant Mouse Growth factor receptor-bound protein 10 (Grb10)

1. ablation of growth factor receptor bound protein 10 (Grb10) in muscle is sufficient to affect muscle size and metabolism, supporting an important role for this protein in growth and metabolic pathways PMID: 29370381
2. DNA methylation at CpG island 1 (CGI1) of Grb10 in blastocysts were also significantly decreased after vitrification PMID: 28696244
3. This study reveals a function for the imprinted gene Grb10 in regulating hematopoietic stem cell self-renewal. PMID: 27806297
4. In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development. PMID: 26000738
5. This study identified Grb10 as a critical regulator of lipid metabolism, the programming of the browning phenotype, and thermogenesis in adipose tissues. PMID: 24746805
6. Negative regulation of Grb10 Interacting GIGYF2 protein on IGF-1 receptor signaling pathway caused diabetic mice cognitive impairment. PMID: 25268761
7. Grb10 is involved in BCR-ABL-positive leukemia in mice. PMID: 25249015
8. Grb10 is a key genetic component of developmental programming. PMID: 24586114
9. Glucose uptake was higher in Grb10(-/-) primary myotubes in the basal state and was associated with enhanced insulin signaling and an increase in GLUT4 translocation to the plasma membrane. PMID: 24664951
10. Grb10 expression in mouse embryo is regulated by Lmx1a transcription factor. PMID: 23106268
11. Results suggest consecutive passaging may affect epigenetic modifications of Grb10 in adult fibroblast cells. PMID: 22971350
12. Study has identified Grb10 as an important regulator of beta-cell proliferation and demonstrated that reducing the expression level of Grb10 could provide a novel means to increase beta-cell mass and reduce beta-cell apoptosis. PMID: 22923474
13. Grb10-ablated muscle from adult mice shows coordinate gene changes that oppose those of muscle wasting pathologies, highlighting Grb10 as a potential therapeutic target for these conditions PMID: 22623587
14. Data suggest that GRB10 is involved in pancreatic alpha cell survival and, as result, plays an important role in regulating basal glucagon secretion and glucose tolerance; studies include both apoptotic and anti-apoptotic signaling of GRB10. PMID: 22222503
15. mTORC1-mediated phosphorylation stabilized Grb10, leading to feedback inhibition of the phosphatidylinositol 3-kinase (PI3K) and extracellular signal-regulated, mitogen-activated protein kinase (ERK-MAPK) pathways PMID: 21659605
16. analysis of the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4 PMID: 20980250
17. Grb10 is, so far, a unique imprinted gene, able to influence distinct physiological processes, fetal growth and adult behaviour, owing to actions of the two parental alleles in different tissues PMID: 21270893
18. Grb10 gene is expressed from the paternal allele in brain, but from the maternal allele in most other tissues. PMID: 17101788
19. These results suggest a role for the Grb10/Nedd4 complex in regulating ubiquitination and stability of the IGF-IR, and they suggest that Grb10 serves as an adapter to form a bridge between Nedd4 and the IGF-IR. PMID: 12697834
20. Grb10 is a critical component of the insulin receptor (IR) signaling complex that provides a functional link between IR and p85 phosphatidylinositol (PI) 3-kinase and regulates PI 3-kinase activity. PMID: 12783867
21. The majority of Grb10 expression arising from the maternally inherited allele. Grb10 action is essentially independent of insulin-like growth factor 2. Grb10 is a potent growth inhibitor. PMID: 12829789
22. Ovexpressed Grb10 effects insulin-regulated glucose transport. PMID: 15664450
23. Taken together, these results indicate that Meg1/Grb10 interacts with both insulin and IGF1 receptors in vivo, and negatively regulates the IGF growth pathways via these receptors. PMID: 15752742
24. Grb10 functions as a specific endogenous suppressor of IGF-I-stimulated cell signaling and DNA synthesis. PMID: 16037382
25. Grb10 adapter protein creates a subpopulation of Raf-1 with specific anti-apoptotic activity in fibroblasts. PMID: 17535812
26. Grb10 forms a link between fetal growth and glucose-regulated metabolism in postnatal life and is a candidate for involvement in the process of fetal programming of adult metabolic health. PMID: 17562854
27. Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo. PMID: 17620412
28. These results indicate that Grb10 and Nedd4 play a critical role in mediating IGF-IR down-regulation by promoting ligand-dependent multiubiquitination of the IGF-IR, which is required for receptor internalization and regulates mitogenesis. PMID: 18286479
29. With high fat diet, the diabetes onset rate of Meg1 Tg mice increased up to 60%. These results suggest that Meg1 Tg mice resemble human 2DM. PMID: 18633161
30. Data indicate that bivalent chromatin, in combination with neuronal factors, controls the paternal expression of Grb10 in brain. PMID: 18650936
31. study reports co-localization of adaptor proteins nShc & Grb10, with Kv1.3 channel in the olfactory bulb neural lamina; BDNF-induced current suppression of the Kv1.3 channel was prevented by both nShc and Grb10 PMID: 19166614
32. Fetal and neonatal growth was very sensitive to the expression level of Meg1/Grb10 Type I, indicating that the 2-fold increment of the Meg1/Grb10 Type I is one of the major causes of the growth retardation. PMID: 19174477
33. Grb10 and Grb14 have roles in regulation of insulin signaling and glucose homeostasis PMID: 19541746
34. Grb10 may play an important role during the development process in mouse. PMID: 19586879
35. Grb10 can influence reproductive strategy through the allocation of maternal resources such that offspring number is offset against size. PMID: 19833122

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KEGG: mmu:14783

STRING: 10090.ENSMUSP00000091011

UniGene: Mm.273117