Recombinant Mouse Growth/differentiation factor 8 (Mstn)

1. the prodomain:GDF8 complex can exist in a fully latent state and an activated or "triggered" state where the prodomain remains in complex with the mature domain PMID: 29348202
2. Myostatin deletion increases lean muscle mass and results in muscle-specific increases in endothelium-dependent vasodilation. PMID: 29192067
3. Indoxyl sulfate enhanced the production of myostatin by enhancing oxidative stress in skeletal muscle, leading to muscle atrophy. PMID: 27549031
4. Myostatin inhibition therapy for insulin-deficient type 1 diabetes has been proposed in an experimental model. PMID: 27581061
5. maternal myostatin deficiency altered fetal growth and calvarial collagen content of newborn mice and conferred a lasting impact on bone geometry and biomechanical integrity of offspring at 4 mo of age. PMID: 27821779
6. Mstn regulates Fndc5/Irisin expression and secretion through a novel miR-34a-dependent post-transcriptional mechanism; loss of Mstn in mice leads to the increased Fndc5/Irisin expression, which contributes to the browning of white adipocytes PMID: 27297797
7. Axon diameter and myelin thickness were increased in motor axons of myostatin deficient animals. PMID: 28073155
8. These data illustrate the importance of lipids as a link by which MSTN deficiency can impact mitochondrial bioenergetics in skeletal muscle. PMID: 28676454
9. Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis. PMID: 29024627
10. These results demonstrate that a greater than additive effect is observed on the growth of skeletal muscle and in the reduction of body fat when myostatin is absent and IGF1 is in excess, and that myostatin and IGF1 regulate skeletal muscle size, myofibre type and gonadal fat through distinct mechanisms. PMID: 28533420
11. Mstn deficiency but not anti-myostatin blockade induces marked proteomic changes in mouse skeletal muscle. PMID: 27214824
12. GDF8 plays a significant regulatory role in bone formation and bone resorption PMID: 28074479
13. Genetic inactivation of myostatin increases maximal force and power, but in return it reduces muscle quality, particularly in male mice. PMID: 27312354
14. findings indicate that myostatin directly influences osteocyte function and thereby inhibits osteoblastic differentiation, at least in part, through the suppression of osteocyte-derived exosomal miR-218, suggesting a novel mechanism in muscle-bone communication. PMID: 28465350
15. The 12-bp Mstn(Cmpt-dl1Abc) deletion decreases adiposity and improves whole body glucose uptake, insulin sensitivity, and (18)FDG uptake of skeletal muscle and white adipose tissue. PMID: 27965203
16. In this model, increased LTBP4 led to greater muscle mass with proportionally increased strength, and decreased fibrosis. The increase in muscle mass and reduction in fibrosis were similar to what occurs when myostatin, a related TGFbeta family member and negative regulator of muscle mass, was deleted in mdx mice PMID: 27148972
17. myostatin dysfunction impairs adaptation of the soleus muscle to high functional demands. PMID: 26304113
18. Evidences indicate that the suppression of MSTN cause to increase the regenerative potential of injured soleus muscle via the increase in the population of muscle satellite cells regardless of unloading conditions. PMID: 27647997
19. A role for Nfix in postnatal skeletal muscle development and regeneration and Myostatin gene expression regulation. PMID: 26923583
20. Myostatin deletion specifically affects skeletal muscle mitochondrial function and redox status. Decreased mitochondrial function and oxidative markers persisted in aged mstn KO mice. However, muscle hypertrophy and the redox status related to this genotype appeared as beneficial side effects attenuating the age effect, as metabolic changes become less pronounced in comparison with WT mice. PMID: 26944368
21. A synthetic peptide corresponding to this decorin region dose-dependently inhibited the response to myostatin in cardiomyocytes PMID: 27559042
22. myostatin may play an important role in maintaining ankle and wrist joint health. PMID: 26549246
23. Agouti-related peptide (AgRP) neuron activation acutely reprograms gene expression in BAT toward a myogenic signature, including increased expression of myostatin. Interference with myostatin activity improves insulin sensitivity that was impaired by AgRP neurons activation. PMID: 27015310
24. Increased expression of myostatin in heart muscle cells caused interstitial fibrosis via activation of the TAK-1-MKK3/6-p38 signaling pathway PMID: 25725788
25. study is the first to report an in vivo association between vitamin D, myostatin, and the regulation of muscle mass PMID: 26340892
26. Report myostatin expression in early postnatal mouse masseter and rectus femoris muscles. PMID: 25982068
27. An age-dependent decline in serum Gdf8 levels was identified. PMID: 26489925
28. Mstn may negatively regulate Igf2 expression to control postnatal skeletal muscle growth, however differences in growth between male and female mice are not readily explained by changes in expression of Igf family members. PMID: 26198127
29. the phenotypic and physiologic impact of postnatal myostatin inhibition on bite mechanics, were examined. PMID: 26252892
30. Data (including data from studies in knockout mice) suggest that myostatin attenuation stimulates adipogenesis in vivo; reduced adiposity in mstn-/- knockout mice results from nutrient partitioning away from fat and in support of muscle. PMID: 26580671
31. analysis of dual exon skipping of dystrophin and myostatin pre-mRNAs using phosphorodiamidate morpholino oligomers conjugated with an arginine-rich peptide PMID: 25959011
32. Data show that circulating myostatin levels decreased with age and estimates of growth differentiation factor 11 (GDF11) levels using myostatin null mice indicate that they were almost 500 times lower than those for myostatin. PMID: 26372181
33. MSTN haploinsufficiency protects against aging-related declines in muscle function and enhances the longevity of mice. PMID: 25808276
34. results reveal that there is a novel pathway in skeletal muscle development in which miR-128 regulates myostatin at CDS region to inhibit proliferation but promote differentiation of myoblast cells. PMID: 25958325
35. Myostatin modulates the expression and secretion of adipokines in fully differentiated 3T3-L1 adipocytes. PMID: 25878062
36. Myostatin deficiency or antibody-mediated inhibition leads to an amelioration of arthritis severity in hTNFtg mice PMID: 26236992
37. Established the myostatin mutated-mouse model in order to study myostatin, which is expressed primarily in skeletal muscle, and negatively regulates skeletal muscle mass. PMID: 25695746
38. novel insights into myostatin regulation at three different mouse developmental timepoints PMID: 25695797
39. FST, SMAD3, TGFBR1, and AcvR1a genes play a vital role in skeletal muscle hypertrophy in the myostatin propeptide transgenic mice. PMID: 25147795
40. Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. PMID: 25304272
41. Myostatin acted through the Ras-Mek-Erk signaling pathway to transcriptionally regulate miR-431 expression C2C12 cells. PMID: 25869071
42. present the First low resolution solution structure of myostatin-free and myostatin-bound states of GASP-1 and GASP-2 PMID: 25657005
43. The susceptibility of skeletal muscles of Mstn(-/-) mice to atrophy during hindlimb suspension is due to an up- and downregulation, respectively, of the mechanisms regulating atrophy of myofibres and translation of mRNA. PMID: 24718581
44. Gasp-1 overexpression resulted in increased myostatin expression. PMID: 25277978
45. Cardiac MTSN activation occurs rapidly after cardiac ischemia. PMID: 25528587
46. reduced sarcoplasmic reticulum calcium release underlies the reduced muscle force in mutant Cmpt animals PMID: 24445322
47. our results reveal an essential role for myostatin in the pathogenesis of cancer cachexia and link this condition to tumor growth, with implications for furthering understanding of cancer as a systemic disease. PMID: 25336187
48. role of myostatin in cardiovascular disease and cachexia PMID: 24680839
49. MyoD expression was detected to identify impact of IGF-1 on myoblasts differentiation when exposed to myostatin. PMID: 24575400
50. mechanical vibration strongly down-regulates atrophy genes myostatin and atrogin-1 both in vivo and in vitro. PMID: 22711460

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KEGG: mmu:17700

STRING: 10090.ENSMUSP00000027269

UniGene: Mm.3514