Recombinant Mouse Inositol hexakisphosphate kinase 1 (Ip6k1)

Code CSB-YP011770MO
MSDS
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Source Yeast
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Code CSB-EP011770MO
MSDS
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Source E.coli
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Code CSB-EP011770MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011770MO
MSDS
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Source Baculovirus
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Code CSB-MP011770MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Ip6k1
Uniprot No.
Alternative Names
Ip6k1; Ihpk1; Inositol hexakisphosphate kinase 1; InsP6 kinase 1; EC 2.7.4.21; Inositol hexaphosphate kinase 1
Species
Mus musculus (Mouse)
Expression Region
1-433
Target Protein Sequence
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE TVEQDDTPER EQPRRKHSRR SLHRSGSGSD HKEEKASLSF ETSESSQEAK SPKVELHSHS DVPFQMLDSN SGLSSEKISY NPWSLRCHKQ QLSRMRSESK DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ STSATLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL KHVDMGLPEV PPPCGPSTSP SSTSLEAGPS SPPKVDVRMI DFAHSTFKGF RDDPTVHDGP DRGYVFGLEN LISIMEQMRD ENQ
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Gene References into Functions
  1. these findings reveal an important role for IP6K1 in regulating Mesenchymal stem/stromal cell fitness and differentiation fate. PMID: 28577302
  2. IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and alpha-actinin through its product 5-diphosphoinositol pentakisphosphate. PMID: 28154132
  3. IP6K1 is a novel regulator of PLIN1 mediated lipolysis PMID: 27373682
  4. IP6K1 regulates energy metabolism via a mechanism that could potentially be targeted in obesity. PMID: 27701146
  5. provides the first evidence for the involvement of IP6Ks in dynein function and proposes that inositol pyrophosphate-mediated pyrophosphorylation may act as a regulatory signal to enhance dynein-driven transport PMID: 27474409
  6. IP6K1 is also involved in early cytoskeleton remodeling events during cancer progression. PMID: 27140681
  7. IP6K1 preferentially bound to the phospholipid phosphatidic acid, and this binding was required for IP6K1 nuclear localization and the regulation of inositol-3-phosphate synthase transcription. PMID: 26953345
  8. IP6K1 is a novel CRL4 subunit that transduces UV signals to mediate disassembly of the CRL4-CSN complex, thereby regulating nucleotide excision repair and cell death. PMID: 25349427
  9. present study demonstrates that IP6K1 physiologically regulates GSK3 kinases. PMID: 23439485
  10. FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression. PMID: 23322705
  11. IP6K1 has a role in regulation of mammalian hemostasis via its control of platelet polyP levels PMID: 23782934
  12. Mouse embryonic fibroblasts (MEFs) lacking IP6K1 exhibit impaired DNA damage repair via homologous recombination. PMID: 23255604
  13. Defects in the mutants indicate important roles for IP6K1 and inositol pyrophosphates in several physiological functions PMID: 18268345

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Inositol phosphokinase (IPK) family
Tissue Specificity
Highly expressed in brain and testis. Detected at much lower levels in heart, kidney, liver, lung and spleen.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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