Recombinant Mouse Integrin alpha-8 (Itga8), partial

Code CSB-YP011871MO
MSDS
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Source Yeast
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Code CSB-EP011871MO
MSDS
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Source E.coli
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Code CSB-EP011871MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011871MO
MSDS
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Source Baculovirus
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Code CSB-MP011871MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Itga8; Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Gene References into Functions
  1. Role of integrin alpha8 in murine model of lung fibrosis PMID: 29813125
  2. Itga8-/- renal mesangial cells showed reduced phagocytosis of matrix-coated beads and apoptotic cells compared to WT renal mesangial cells. PMID: 29544224
  3. alpha8 Integrin is expressed in functional placental compartments among its ligands, OPN and/or FN, across species. Although this may point to a regulatory role in trophoblast function, our data from alpha8 integrin-deficient mice indicated only mild placental pathology. PMID: 28136130
  4. Study observed that in the Apoe-deficient model of atherosclerosis, the female sex is a risk factor to develop more severe atherosclerotic lesions, although serum fat levels are not higher in females than in males. In contrast, female mice are protected from renal damage induced by the concomitant deficiency of Apoe and Itga8 PMID: 28572914
  5. Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism. PMID: 27092791
  6. Itga8 seems to attenuate tubulointerstitial fibrosis in unilateral ureteral obstruction not via regulation of cell turnover, but via regulation of TGF-beta signalling, fibroblast activation and/or immune cell infiltration PMID: 26938996
  7. Fibrillin-1 and alpha8 integrin interact, and thus, regulate mesangial cell adhesion and migration. PMID: 25482639
  8. Alpha 8 integrin expression is strongly induced in a mouse model of renal fibrosis. PMID: 23144868
  9. The findings indicate that QBRICK facilitates the integrin alpha8beta1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome. PMID: 22613833
  10. Lack of alpha8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells. PMID: 21194485
  11. Mice mutant for alpha8-integrin exhibit a specific impairment of long-term potentiation at synapses of Schaffer collateral-CA1 field of the hippocampus. PMID: 20132319
  12. alpha8-integrin is protective for the structure and function of the glomerulus and maintains podocyte integrity during the development of diabetic nephropathy PMID: 20826576
  13. Lack of alpha8 causes unilateral or bilateral renal agenesis, significantly reduced renal mass, and higher blood pressure. Many alpha8-deficient mice had malformations of the kidney with collapse or atrophy of tubuli and interstitial cell infiltrates. PMID: 12386295
  14. Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury. PMID: 12787402
  15. Integrin alpha8beta1-fibronectin-mediated survival appears to be mediated by the PI3 kinase pathway PMID: 15721307
  16. Interactions between alpha(8)-integrin and the mesangial matrix may contribute to healing of glomerular injury by influencing cell proliferation and apoptosis PMID: 17951999
  17. Lack of alpha8 integrin does not reduce fibrotic changes in the hearts of DOCA-salt hypertensive mice. PMID: 19008864
  18. The induction of -integrin in -smooth muscle actin (-SMA) positive myofibroblasts of the liver and heart suggests that -integrin might modulate the function of activated myofibroblasts, cells contributing to fibrotic remodeling. PMID: 19096376
  19. we propose that integrin alpha8beta1 plays a critical role in lung morphogenesis by regulating mesenchymal cell adhesion and migration PMID: 19769957

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Subcellular Location
Membrane; Single-pass type I membrane protein. Cell membrane.
Protein Families
Integrin alpha chain family
Tissue Specificity
In brain, expressed in deep cortex, hippocampal CA1, basolateral amygdala and striatum. In kidney, expressed in glomerular mesengium (at protein level).
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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