Recombinant Mouse Interferon regulatory factor 4 (Irf4)

1. MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression PMID: 28808358
2. study identifies IRF4 as central regulator of TH1 responses and cellular metabolism. We propose that this function of IRF4 is fundamental for the initiation and maintenance of all TH cell responses. PMID: 27762344
3. Nur77 suppresses CD4(+) T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3(+) and IL-4(+) cells. PMID: 28538176
4. Muramyl dipeptide reduces fat inflammation and liver insulin resistance via NOD2. NOD1-activating muropeptides exacerbate glucose intolerance. IRF4 dictates insulin-sensitizing effects of NOD2, but not NOD1, muropeptides. PMID: 28434881
5. Young mice had higher levels of IRF4 in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses. PMID: 28905935
6. IRF4 is highly induced in graft-infiltrating T cells and is required for heart transplant rejection. PMID: 29221730
7. The findings indicate that IRF4 functions as a central node in a TCR-responsive transcriptional circuit that establishes and sustains T cell exhaustion during chronic viral infection. PMID: 29246443
8. RHS6 is a critical regulatory element for allergic airway inflammation and for coordinate regulation of Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4. PMID: 27878828
9. this study shows that epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells PMID: 28189772
10. Cell fate and metabolic state are linked by transcriptional regulators, such as IRF4 and FoxO1, with dual roles in lineage and metabolic choice. Instructing some cells to utilize nutrients for anabolism and differentiation while other cells catabolically self-digest and self-renew may enable growth and repair in metazoa. PMID: 28009285
11. Here the authors show that concomitant loss of Tet2 and Tet3 in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 expression and impaired the germline transcription and rearrangement of the Igkappa locus. PMID: 27869616
12. IRF4 protects arteries against neointima formation by promoting the expression of KLF4 by directly binding to its promoter. PMID: 28851732
13. Data show that Fos-Related Antigen-2 (Fra-2) is a key upstream regulator of forkhead box O1 (Foxo1) and interferon regulatory factor 4 (Irf4) expression and influences proliferation and differentiation of B cells at multiple stages. PMID: 28566276
14. GM-CSF can mediate inflammation and pain by regulating IRF4-induced CCL17 production PMID: 27525438
15. MTORC2 operated in parallel with the IL-4Ralpha-Stat6 pathway. PMID: 27760338
16. IRF4 mRNA and protein expression was remarkably suppressed during the development of myeloid-derived suppressor cells in the tumor microenvironment. IRF4 expression in MDSCs can modulate their activity to inhibit T cell proliferation through IL-10 production and ROS generation, and myeloid-specific deletion of IRF4 leads to the increase of MDSC differentiation. IRF4 reduction induced by tumors can increase MDSC numbers. PMID: 27601624
17. propose that Irf4 is imperative for thymic Treg homeostasis because it regulates thymic epithelial cell-specific expression of several chemokines and costimulatory molecules indicated in thymocyte development and Treg induction PMID: 28108558
18. MHC II(+) resident peritoneal and pleural macrophages are continuously replenished by blood monocytes recruited to the peritoneal and pleural cavities constitutively, starting after birth, where they require IRF4 and signals likely derived from the microbiome to fully differentiate. PMID: 27551152
19. this study shows that PU.1 functions as a positive regulator of CD11c gene expression by directly binding to the Itgax promoter and through transactivation of the Irf4 gene PMID: 28338898
20. this study shows that the affinity of different enhancers for the BATF-IRF4 complex might underlie divergent signaling outcomes in response to various strengths of TCR signaling PMID: 28346410
21. this study shows that baicalin upregulates IRF4 protein expression and alleviates colitis by modulating macrophage polarization to the M2 phenotype PMID: 27039210
22. data reveal that CCR7 plays multifaceted roles in regulating collecting vessel permeability and fibrosis, with one of the key players being IRF4-dependent DCs. PMID: 26999610
23. IRF4 was essential for the survival of plasma cells. PMID: 26779600
24. a critical role for IRF4 in regulating protective anti-viral CD8+ T cell responses by ensuring a balanced ratio of T-bet to Eomes PMID: 26714260
25. variation in IRF4 or IRF8 levels resulting from genetic polymorphisms or environmental cues will govern tissue dendritic cells numbers and regulate the magnitude of their functional responses. PMID: 26746189
26. DC dysfunction in lupus-prone mice relies on both IRF4-dependent and IRF4-independent pathways PMID: 26544714
27. APN can help to reduce periodontitis-related bone loss, modulate JMJD3 and IRF4 expression, and macrophage infiltration. PMID: 26399931
28. Data indicate that interferon regulatory factors IRF4 and IRF8 control distinct activated B cell states. PMID: 26437243
29. this study determined the small angle x-ray scattering solution structure of full-length IRF4, which, together with circular dichroism studies, suggests that the linker region is not extended but folds into a domain structure PMID: 26405037
30. data support a novel and critical role for Nr4a1 in the regulation of CD8(+) T cell expansion and effector function through transcriptional repression of Irf4. PMID: 26363057
31. inhibition of IRF4 attenuates acute liver allograft rejection in mice, and this is associated with promoted M2 macrophage differentiation. PMID: 26095713
32. NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6. PMID: 24670424
33. The transcription factors IRF4 and BATF are major regulators of antiviral cytotoxic T-cell immunity. PMID: 24531538
34. miR-125b induces myeloid and B-cell leukemia by inhibiting IRF4 through distinct mechanisms, inducing myeloid leukemia through repressing IRF4 at the mRNA level without altering genomic DNA and B-cell leukemia via deletion of the gene encoding IRF4 PMID: 25006123
35. we have shown that the IRF4-SRF axis is a novel signalling pathway critical for neuronal survival in the setting of ischaemic stroke. PMID: 24510125
36. both IRF3 and IRF4 are induced by adiponectin, with adiponectin-AMPK and adiponectin-PPARalpha signalling regulating IRF3 and IRF4, respectively. PMID: 24627105
37. Murine gammaherpesvirus 68 reactivation from B cells requires IRF4 but not XBP1. PMID: 25078688
38. Study shows that IRF4 is transcriptionally regulated by cold and cAMP in murine and human brown adipose tissue (BAT) prior to the induction of Ucp1 and that mice that overexpress IRF4 transgenically in BAT display enhanced thermogenic gene expression, energy expenditure, and cold tolerance. PMID: 24995979
39. IRF4 is a key component that translates the strength of TCR signaling into a graded response of virus-specific CD8(+) T cells. PMID: 24835398
40. The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity. PMID: 24711583
41. IRF4 expression is upregulated during osteoclast differentiation induced by RANKL. PMID: 24039733
42. Data indicate that transcription factor IFN regulatory factor 4 (IRF4) was required for the development of early germinal centers (GCs) B cells. PMID: 24591370
43. These results imply that IRF4 expression in DCs inhibits their ability to produce IL-12 while promoting their migratory behavior, thus regulating CD4(+) T cell responses against local infection with L. major. PMID: 24489086
44. IRF4 functions as a specific regulatory determinant for CD11b+ DC subsets and programs the enhanced expression of genes required for MHC class II antigen presentation, thereby enabling such cells to more efficiently prime helper T cell responses in vivo. PMID: 24362890
45. T-bet negatively regulates Th17 lineage commitment via direct repression of IRF4. PMID: 24249732
46. IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression PMID: 24323359
47. IRF4 was vital for sustaining the expansion & effector differentiation of T8 cells. It promoted Blimp1 & T-bet expression & function, & repressed cell-cycle-arrest & apoptosis genes. Loss impaired antiviral immunity. PMID: 24211184
48. IRF4 is a novel regulator in the pathogenesis of chronic lymphocytic leukemia PMID: 23897826
49. IRF4 is crucial for the protective CD8+ T-cell response to L. monocytogenes. IRF4-deficient mice could not clear L. monocytogenes infection and generated decreased numbers of L. monocytogenes-specific CD8+ T cells with impaired phenotype and function. PMID: 23980171
50. The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. PMID: 24056747

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KEGG: mmu:16364

STRING: 10090.ENSMUSP00000021784

UniGene: Mm.4677