Recombinant Mouse Interleukin-18 receptor 1 (Il18r1), partial

Code CSB-YP726734MO
MSDS
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Source Yeast
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Code CSB-EP726734MO
MSDS
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Source E.coli
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Code CSB-EP726734MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP726734MO
MSDS
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Source Baculovirus
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Code CSB-MP726734MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Il18r1; Interleukin-18 receptor 1; IL-18R-1; IL-18R1; EC 3.2.2.6; CD218 antigen-like family member A; IL1 receptor-related protein; IL-1Rrp; IL1R-rp; Interleukin-18 receptor alpha; IL-18R-alpha; IL-18Ralpha; CD antigen CD218a
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3.
Gene References into Functions
  1. IL-18R-immunoreactive neurons were present in layers II, III and VI of the retrosplenial cortex in 2-week-old mice, whereas they were sparsely observed in only layer III in 3-week-old mice. No IL-18R-ir neurons were present in 4- and 5-week-old mice. In older than 6-week-old mice, many IL-18R-ir neurons were present in layers V and VI. PMID: 29681594
  2. IL-18Ralpha-mediated signaling pathway plays critical role in CD4+ T cells and antigen-presenting cells response in LPS-induced acute kidney injury. PMID: 29261164
  3. These findings establish the T-cell intrinsic IL-18R/MyD88 pathway as a crucial element for induction of cognate Th1 responses against an important human pathogen. PMID: 28895840
  4. Despite these findings however, IL-18Ralpha-deficient CD4(+) T cells induced comparable intestinal pathology to WT CD4(+) T cells. These findings suggest that IL-18-dependent cytokine induced activation of CD4(+) T cells is not critical for the development of T-cell-mediated colitis. PMID: 27062602
  5. strong evidence that IL-18 and IL18Ralpha have important functions in the pathogenesis of allergic asthma PMID: 26561030
  6. IL-37 requires IL-18Ralpha and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice PMID: 25557042
  7. IL-37 requires the receptors IL-18Ralpha and IL-1R8 to carry out its multifaceted anti-inflammatory program upon innate signal transduction. PMID: 25729923
  8. data reveal that IL-18Ralpha has an anti-inflammatory effect in IRI-induced AKI. Above all, IL-18 enhanced the inflammatory mechanisms and the apoptosis of TECs through the Fas/FasL pathway by blocking IL-18Ralpha PMID: 25329004
  9. compared IL-18Ralpha knockout with wild-type mice in cisplatin-induced acute kidney injury and found deteriorated kidney function, tubular damage, and increased accumulation of leukocytes PMID: 22673883
  10. The presence or absence of IL-18 receptor alpha signals governs pathogenic versus protective immunity in a model of Ehrlichia-induced immunopathology. PMID: 21715688
  11. These data suggest a role for IL-1F family members in psoriasis. PMID: 20833839
  12. review of structure, function and tissue distribution of IL-18R [review] PMID: 15323361
  13. IL-18R alpha and IL-17-producing T helper cells are required for autoimmune central nervous system inflammation. PMID: 16906165
  14. IL-18Ralpha gene expression is regulated by estrogen and progesterone and that the uterine IL-18 system is involved in the regulation of uterine functions in a paracrine manner PMID: 17062984
  15. islets from mice deficient in IL-18 receptor alpha chain (IL-18R) exhibited rapid graft failure PMID: 17075045
  16. IL-18 signaling in BSA nephritis mice significantly alleviates immune complex renal disorder; this may thus represent a novel approach to the treatment of patients with immune complex nephritis. PMID: 18462998
  17. Ectopic expression of GATA-3 in differentiated Th1 cells repressed Il18r1 mRNA and surface expression of IL-18Ralpha. PMID: 18714006
  18. The authors found that signaling through the IL-18 receptor is not required for normal T-cell response kinetics and survival of immunized mice challenged with a lethal L. monocytogenes infection. PMID: 19223481
  19. a role for SOCS1 and -3 in the seemingly paradoxical hyperresponsive state in cells deficient in IL-18Ralpha, supporting the concept that IL-18Ralpha participates in both pro- and anti-inflammatory responses PMID: 19592492

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Interleukin-1 receptor family
Database Links
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