Recombinant Mouse Interleukin-21 receptor (Il21r), partial

1. In mice, IL-21:IL-21R interactions influence the phenotype of T follicular cells, reducing the expression of CXCR4 and inhibiting the expansion of Tfr cells after T-cell-dependent immunization. The negative effect of IL-21 on Tfr cells in mice is cell intrinsic and associated with decreased expression of the high affinity IL-2 receptor (CD25). PMID: 28303891
2. IL21R signal my contribute to anti-adenine nucleotide translocator antibody production and expansion of B cells in viral myocarditis PMID: 28550395
3. this study shows that IL-21R signaling is essential for the optimal control of Mycobacterium tuberculosis infection PMID: 28855309
4. natural genetic variation in murine Il21r influences neuronal cell viability after ischemia by modulating receptor function and downstream signal transduction PMID: 27400126
5. IL-21 may play an important role in the pathogenesis of SSc as a Th17 effector cytokine, and IL-21 may induce the differentiation of Th17 cells in the BLM-induced systemic sclerosis mouse model via Il21R. PMID: 25545680
6. Gene expression analyses of angioimmunoblastic T-cell lymphoma (AITL), showed that essentially all cases expressed elevated levels of transcripts for IL21, IL21R, and a series of genes associated with TFH cell development and function. PMID: 26363366
7. IIl21r deletion reduced spontaneous EAE associated with defective Th17 cell generation. IL-21R deficiency limited IL-23R expression on Th17 cells and inhibited expression of key molecules for pathogenic Th17 cell generation. PMID: 26413871
8. our data demonstrate the novel finding that the IL-21R plays a critical role in regulating innate immune responses against HSV-2 infection. PMID: 24358128
9. During experimental arthritis, IL-21R deficiency protected against severe inflammation and joint destruction. This was accompanied by suppressed serum IgG1 levels and antigen-specific T cell responses. PMID: 24757141
10. in the absence of IL-21/IL-21R signaling, Il2(-/-) mice retained a deficiency in Tregs yet exhibited a reduced and delayed inflammatory disease which was reflected in reduced pancreatitis and hemolytic anemia PMID: 24446516
11. IL-21R expression on donor CD4+ T cells is essential for sustaining T cell number and help for B cells, resulting in more severe lupus-like renal disease, but it does not alter the balance of T helper (Th)17 cells and regulatory T cells. PMID: 22723520
12. IL-21R controls both antigen transport by DCs and the crucial beacon function of CD4(+) cells for autoreactive CD8(+) cells to reach the islets. PMID: 22579473
13. Data indicate that CD8KO recipients given either C57Bl/6 or IL-21RKO CD8+ cells showed the recipients given C57Bl/6 CD8+ cells with significantly greater myocarditis than recipients of IL-21RKO CD8+ cells. PMID: 22465422
14. IL-21 and IL-2 can have overlapping roles in promoting conventional T-cell responses but play distinct roles in controlling Treg homeostasis and function. PMID: 22442347
15. study demonstrated T-extrafollicular helper cells are dependent on IL-21R for their generation; study highlighted that IL-21R signaling is necessary for the spontaneous accumulation of multiple B and T cell effector populations in MRLlpr mice PMID: 22231702
16. IL-21R KO and wild-type donor T cells showed equivalent alloactivation, but IL-21R KO T cells showed decreased infiltration and inflammatory cytokine production within the mesenteric lymph nodes. PMID: 21596854
17. Following secondary immunization of IL-21 receptor knockout mice, IgG antibody responses to hapten-onjugated chicken gamma globulin are significantly impaired, identifying the IL-21 pathway as a critical component of the memory B cell response. PMID: 21169545
18. Recipients of donor CD4-positive T cells lacking IL-21 receptor exhibit diminished graft-versus-host disease symptoms, with reduced inflammatory cell infiltration into the liver and intestine, leading to prolonged survival PMID: 20574002
19. Germinal center reactions and B cell responses induced by immunization with virus-like particles are strongly reduced in both global and B cell-specific IL-21 receptor-deficient mice. PMID: 20368279
20. Increased IL-21 and IL-21R expression may be involved in the development of experimental autoimmune uveitis, possibly by promoting IL-17 secretion. PMID: 20057909
21. The common gamma chain (gamma c) is a required signaling component and supports IL-21-induced cell proliferation via JAK3 PMID: 12093291
22. IL-21 plays a crucial role in supporting polarized Th2 responses in vivo, while appearing superfluous for Th1 and Th17 responses PMID: 17077330
23. provides preliminary evidence for a role of IL-21 in modulating the severity of systemic lupus erythematosus in BXSB-Yaa mice PMID: 17911475
24. data demonstrate that the absence of IL-21 or IL-21R does not critically influence FoxP3+ Treg and Th17 cell differentiation, organ recruitment, and associated inflammatory diseases in models of CNS and heart autoimmunity PMID: 18546146
25. These results suggest an important role for IL-21R in the mobilization of skin dendritic cells to draining lymph nodes and the subsequent allergic response to epicutaneously introduced antigen. PMID: 19075398
26. IL-21 arising from an abnormal population of CD4 T cells is thus central to the development of SLE, and, more generally, could play an important role in human SLE and related autoimmune disorders. PMID: 19164519
27. endogenous IL-21/IL-21R is not required for NK, NKT, and CD8(+) T cell-mediated tumor immunity PMID: 19915059
28. The IL-21 receptor is a target for the therapy of fibrosis and diseases asssociated with chronic Th2 cytokine responses, including liver cirrhosis and asthma. PMID: 16778988

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KEGG: mmu:60504

STRING: 10090.ENSMUSP00000033000

UniGene: Mm.155643