Recombinant Mouse Krueppel-like factor 2 (Klf2)

1. miRNA-92a may function through regulating KLF2. PMID: 29660330
2. the data revealed that puerarin inhibited the monocyte adhesion in vitro and in vivo and thus reduced atherosclerotic lesions in apoE-/- mice; the protective effects were mediated by activation of ERK5/KLF2 signaling pathway. PMID: 29723698
3. Suberanilohydroxamic acid has KLF2-dependent anti-inflammatory effects, repressing vascular inflammation and atherosclerosis. PMID: 29191808
4. any one of Klf2, Klf4 and Klf5 was sufficient to support self-renewal of mouse embryonic stem cells, whereas the removal of all three compromised it. PMID: 29739838
5. KLF2 induces an antiproliferative secretome, including activin A, which attenuates liver regeneration. PMID: 28348240
6. miRNA92a targets KLF2 and PTEN signaling to promote human T follicular helper precursors in type 1 diabetes mellitus islet autoimmunity. PMID: 27791035
7. peripheral tolerance is enhanced or diminished through modulation of Treg trafficking tosecondary lymphoid organs (SLOs), a process that can be controlled by adjusting KLF2 protein levels. PMID: 27462110
8. KLF2 and KLF4 serve as important regulators that promote hemoglobin alpha expression in the endothelium. PMID: 28825355
9. Mouse embryos deficient in Orai1, Klf2, or Klf4 showed a significantly reduced lymphatic density and impaired lymphatic development. PMID: 28167653
10. this study shows that KLF2 governs the degree of dendritic cells activation and hence the intensity of proatherogenic T cell responses PMID: 27837103
11. Transcription factor Kruppel-like factor 2 (KLF2) of the zinc finger family of DNA-binding proteins has recently emerged as a major molecular switch that controls endothelial homeostasis. PMID: 27855271
12. our data demonstrate a protective role of KLF2 against glomerular endothelial cell injury and progression of chronic kidney disease in the model of compensatory renal hypertrophy PMID: 27317905
13. KLF2 knockdown markedly reduced expression of miR-155 in macrophages and macrophage activation. PMID: 26406238
14. study therefore establishes the pivotal role of Klf2 and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt/beta-catenin signaling. PMID: 26321140
15. endothelial-specific loss of Mekk3, Klf2 or Klf4 markedly prevents cerebral cavernous malformation lesion formation, reverses the increase in Rho activity, and rescues lethality PMID: 27027284
16. knockdown of Klf2 expression in endothelial cells induced more endothelial cell injury in early diabetic nephropathy PMID: 25185079
17. Cineromycin B inhibited adipocyte differentiation in 3T3-L1 cells mainly via upregulation of KLF2 and KLF3 mRNA expression at an early stage of the differentiation. PMID: 26092481
18. Data reveal a novel role of HDAC5 in modulating the KLF2 transcriptional activation and eNOS expression. PMID: 25096223
19. inhibition of leukocyte adhesion by Myocyte enhancer factor 2 C was partially mediated by induction of KLF2 PMID: 25474999
20. KLF2 is pivotal for coordinating CD4(+) T cell differentiation through two distinct and complementary mechanisms: via control of T cell localization and by regulation of lineage-defining transcription factors. PMID: 25692701
21. The Kruppel-like factor 2 (Klf2) is phosphorylated by Erk2 and that phospho-Klf2 is proteosomally degraded. PMID: 24905170
22. reveals a beta1 integrin-Klf2-Egfl7-signaling pathway that is tightly regulated by cerebral cavernous malformation proteins PMID: 25625207
23. ICOS maintains the T follicular helper cell phenotype by down-regulating Kruppel-like factor 2. PMID: 25646266
24. Data show that Kruppel-like transcription factors KLF2 expression is decreased in mediator complex Med23 null thymocytes. PMID: 25054639
25. Shear stress-mediated repression of endothelial cell metabolism via KLF2 and PFKFB3 controls endothelial cell phenotype. PMID: 25359860
26. microRNAs miR-124a and miR-150 are reduced when proinflammatory mediator expression is increased in KLF2-deficient macrophages PMID: 25248747
27. KLF2 is not only a key player in terminating pre-B cell clonal expansion but also a potent suppressor of B cell activation. PMID: 24874925
28. This study represents the first description of a significant role of myeloid KLF2 in neuroinflammation. PMID: 25052583
29. KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. PMID: 24979767
30. The thromboprotective effect of bortezomib is KLF2 dependent. PMID: 24771858
31. a novel link between KLF2-induced hepatic triglyceride accumulation and the expression of CD36. PMID: 23861552
32. The present study explores the importance of KLF2 downregulation and reveals that the loss of KLF2 controls a select portion of the CD8 effector T cell transcriptional program. PMID: 24155966
33. Study defines the roles of KLF2 and KLF4 in the embryonic development of blood vessels. It indicates that the two genes interact to maintain an intact endothelial layer. KLF2 and KLF4 positively regulate the eNOS, VEGFR2 and occludin genes. PMID: 24261709
34. Kruppel-like factor 2 might mediate the rapamycin-induced arterial thrombosis in vivo. PMID: 23876886
35. Data indicate taht regulation of KLF2 and S1P1 (S1pr1) provides a switch that dictates whether CD8(+) T cells commit to recirculating or tissue-resident memory populations. PMID: 24162775
36. Plaque vulnerability correlated negatively with KLF2 but positively with PAR-1. Upregulation of KLF2 and downregulation of PAR-1 could be direct or indirect effects of statin therapy. PMID: 23395513
37. IL-17 suppresses expression of PPARgamma, C/EBPalpha, KLF15, a pro-adipogenic transcription factor, and enhances expression of KLF2 and KLF3, which are anti-adipogenic. PMID: 23332504
38. Echocardiography of KLF2-/- embryos indicates that they have abnormal heart function compared to wild-type. PMID: 23457456
39. KLF2 protects blood-brain barrier through regulation of occludin. PMID: 23335794
40. This study documents a role for myeloid KLF2 expression in modulating atherosclerosis. PMID: 22474254
41. The data provide new insights and evidences of KLF2-mediated transcriptional regulation of arthritis via modulation of monocyte differentiation and function. PMID: 22280353
42. Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2. PMID: 22267843
43. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells PMID: 22143796
44. identify HIF-1alpha and KLF2 as critical regulators of gram-positive endotoxin-mediated sepsis. PMID: 22110137
45. KLF2 directly transactivates the reelin promoter in erythroid cells. PMID: 21530336
46. identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo PMID: 21565532
47. An ERK5/Sp1/Klf module plays a key role in the fusion process during skeletal muscle differentiation. PMID: 21316587
48. KLF2 has a role in B cell homeostasis and plasma cell homing PMID: 21187409
49. KLF2 plays a critical role in dictating normal subset differentiation and functional reactivity of mature B cells PMID: 21187410
50. Although KLF2 has a direct and profound effect on expression of key trafficking molecules, such as sphingosine-1-phosphate receptor-1 (SIP1) and CD62L, transcription of cell cycle-related genes is only modestly influenced by endogenous KLF2. PMID: 21160050

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KEGG: mmu:16598

STRING: 10090.ENSMUSP00000064823

UniGene: Mm.26938