Recombinant Mouse Leucyl-cystinyl aminopeptidase (Lnpep), partial

1. Significant role for IRAP in postnatal brain development and normal function of the hippocampus in adulthood. PMID: 27713012
2. IRAP is more highly expressed in pro-inflammatory M1-activated macrophages. PMID: 24532823
3. IRAP deficiency may lead to suppression of PAI-1 expression in adipocytes and upregulation of UCP-1-mediated thermogenesis in brown adipose tissue and increased energy expenditure to prevent the development of obesity. PMID: 25534853
4. The current study demonstrates that deletion of the IRAP gene protects the brain from ischemic damage PMID: 21895534
5. IRAP-deficient mice are less sensitive to the development of acute pentylenetetrazol-induced seizures, demonstrating that IRAP may be involved in generalized seizure generation. PMID: 21612947
6. requirement of IRAP in cross-presentation extends to steady-state conventional dendritic cells (cDCs);data suggest increased recruitment of an IRAP(+)/Rab14(+) compartment to Ag-containing vesicles contributes to cross-presentation efficacy of CD8(+)cDCs PMID: 22238454
7. These findings suggest that the IRAP binding protein, vimentin, plays an important role in retention of GLUT4 storage vesicles. PMID: 21216232
8. IRAP functions in GLUT4 sorting from endosomes to GLUT4-specialized compartments. PMID: 20410133
9. study shows the high-affinity binding site for angiotensin IV is absent in IRAP knockout mice brain sections in parallel with loss of IRAP immunostaining, providing irrefutable proof that IRAP is the specific high-affinity binding site for AT(4) ligands PMID: 19660563
10. Data suggest that the physiological significance of circulating insulin-regulated aminopeptidase during human pregnancy cannot be addressed by investigations on mice. PMID: 19647771
11. Initial characterization of knockout mice in which IRAP/P-LAP was deleted revealed that GLUT4 protein levels were dramatically decreased in all fat and muscle tissues. PMID: 12700100
12. GLUT4 overexpression or deficiency affects the amount of other GLUT4-vesicle proteins including IRAP and VAMP2. PMID: 14985357
13. GLUT4 and IRAP content of early endosome-derived sorting vesicles and of intracellular membrane vesicles are coordinately regulated. PMID: 15231875
14. The sub-cellular localization of IRAP in neurons demonstrated in the present study bears striking parallels with distribution of IRAP in insulin responsive cells, where the enzyme plays a role in insulin-regulated glucose uptake. PMID: 17504262
15. Changes in plasma and brain vasopressin levels in IRAP(-/-) mice suggest a significant role for IRAP in regulating vasopressin. PMID: 17684103
16. GGA clathrin adaptors are not required for the re-entry of IRAP from the cell surface back into the IRC, whereas the Q-SNARE syntaxin 6 is required for this process PMID: 18388312
17. Data suggest that modulation of glucose uptake by angiotensin IV and LVV-hemorphin 7 is dependent on colocalisation between IRAP and GLUT4, and confirm a role for IRAP and GLUT4 in activity-dependent glucose uptake in hippocampal neurones. PMID: 18702730
18. lumenal interactions between Glut4 and IRAP play an important role in the assembly of the Glut4 storage vesicles PMID: 18713752
19. Results suggest that placental leucine aminopeptidase might be involved in the increased oxytocin (OT) sensitivity just prior to onset of labor and also in the onset of labor by degradation of OT. PMID: 19249316
20. study found a role for peptide trimming by IRAP in cross-presentation; in dendritic cells, IRAP was localized to a Rab14+ endosomal storage compartment in which it interacted with MHC class I molecules PMID: 19498108
21. AngIV-AT4R signaling has a key role in fibrinolysis and the subsequent formation of arterial thrombosis after vascular injury. PMID: 19745198

Show More

Hide All

KEGG: mmu:240028

STRING: 10090.ENSMUSP00000036998

UniGene: Mm.328807