Recombinant Mouse Matrix Gla protein(Mgp)

Code CSB-YP013789MO
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Source Yeast
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Code CSB-EP013789MO
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Source E.coli
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Code CSB-EP013789MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP013789MO
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Source Baculovirus
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Code CSB-MP013789MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Mgp
Uniprot No. P19788
Alternative Names Mgp; Mglap; Matrix Gla protein; MGP
Species Mus musculus (Mouse)
Expression Region 20-104
Target Protein Sequence Y ESHESMESYE ISPFINRRNA NTFMSPQQRW RAKAQKRVQE RNKPAYEINR EACDDYKLCE RYAMVYGYNA AYNRYFRQRR GAKY
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Gene References into Functions
  1. We propose MGP as a strong candidate for the regulation of stiffness in glaucoma. MGP further illustrates the presence of a common function affecting key glaucomatous parameters in the front and back of the eye, and thus offers the possibility for a sole therapeutic target for the disease. PMID: 27593913
  2. the nasal septum to be abnormally mineralized and shortened in Mgp(-/-) mice. Transgenic restoration of Mgp expression in chondrocytes fully corrected the craniofacial anomalies caused by MGP deficiency, suggesting a local role for MGP in the developing nasal septum. PMID: 28487368
  3. loss of MGP causes dysregulation of early endothelial differentiation. PMID: 26364300
  4. Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 deficiency. PMID: 25614167
  5. expression of MGP and OCN increased gradually in the murine developing tibial epiphysis, and the two mineral-associated proteins may occur at the same location during a particular period, but at different levels. PMID: 24956112
  6. Matrix Gla's restricted expression to glaucoma-associated tissues from anterior and posterior segments suggests its involvement in the development of the disease. PMID: 25711639
  7. Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice. PMID: 23857752
  8. The arterial calcification, not MGP deficiency itself, causes the low bone mass phenotype in Mgp-/- mice. PMID: 23994172
  9. Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 and elastin fragmentation associated with induction of adipsin. PMID: 24036114
  10. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways PMID: 23110920
  11. Mgp gene deletion may have a role in arteriovenous malformations PMID: 21765215
  12. role in vascular calcification in vivo PMID: 12391016
  13. MGP is a known inhibitor of mineralization, and mice deficient in Mgp show severe vascular calcification and premature bone mineralization. PMID: 16612082
  14. Inorganic phosphate(Pi) regulates MGP expression in growth plate chondrocytes, thereby suggesting a key role for Pi and ERK1/2 in the regulation of bone formation. PMID: 17068135
  15. PTH regulates MGP via both PKA- and ERK-dependent pathways. PMID: 17407158
  16. Matrix GLA protein is an inhibitory morphogen in pulmonary vascular development PMID: 17670744
  17. MGP in Abcc6-/- mice is largely in inactive form and is unable to prevent the unwanted mineralization of connective tissues in PXE. PMID: 17942075
  18. Extensive hypomineralization was observed in dentin and alveolar bone from transgenic mice expressing matrix Gla protein when compared with that in wild-type tissues. Mineralization was virtually absent in tooth root dentin and cellular cementum. PMID: 18719210
  19. Oral anticoagulant treatment decreased local expression of MGP. PMID: 19350115
  20. Inorganic phosphate regulates MGP expression in osteoblasts through the ERK1/2-Fra-1 pathway. PMID: 19419315
  21. Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein. PMID: 19661459

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Subcellular Location Secreted
Protein Families Osteocalcin/matrix Gla protein family
Database Links

KEGG: mmu:17313

STRING: 10090.ENSMUSP00000032342

UniGene: Mm.243085

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