Recombinant Mouse Metalloproteinase inhibitor 3 (Timp3)

1. Loss of TIMP3 is associated with germinal matrix hemorrhage-intraventricular hemorrhage. PMID: 29456135
2. altered cortical and trabecular bone mineralization and increased compositional heterogeneity were found in Timp-3 (-/-) bone, all being indicative of high bone remodeling PMID: 28236102
3. In a clinically relevant CADASIL mouse model, we show that exogenous ADAM17 or HB-EGF restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3-induced deficits. PMID: 27476853
4. TIMP3 promotes normal microvascular endothelial cell barrier function, at least partially, through inhibition of metalloproteinase-dependent disruption of adherens junctions, and septic downregulation of TIMP3 may contribute to septic MVEC barrier dysfunction. PMID: 26993226
5. data strongly suggest that TIMP3 has direct neuroprotective effects that can mitigate the deleterious effects associated with TBI, an area with few if any therapeutic options. PMID: 26299440
6. Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions. PMID: 26648042
7. 4-Hydroxyisoleucine improved insulin resistant-like state in 3T3-L1 adipocytes by targeting TACE/TIMP3 and the insulin signaling pathway. PMID: 26527864
8. In a mouse model of prostate cancer, increased tumor growth, proliferation index, increased microvascular density, and invasion was observed in Pten(-/-), Timp3(-/-) prostate tumors compared to Pten(-/-), Timp3(+/+) tumors. PMID: 26332574
9. Timp3 status determines p53, p38 and Notch coactivation to instruct hepatic cell fate and transformation. PMID: 25347747
10. lack of TIMP3 increases inflammation and polarizes macrophages towards a more inflammatory phenotype resulting in increased atherosclerosis. PMID: 24943223
11. TIMP-3 KO mice exhibit enhanced metabolism, as reflected by a higher body temperature than WT mice, possibly due to increased mitochondrial activity. PMID: 24736588
12. TIMP3 protects kidney from damage PMID: 23760282
13. TIMP3 reduction is due, at least in part, to increased expression of certain TIMP3-targeting microRNAs in diabetic kidneys compared to healthy controls. PMID: 23797704
14. Demonstrate a critical role for TIMP3, among all TIMPs, in preserving arterial remodelling in response to Ang II-induced hypertension. PMID: 23524300
15. TIMP-3 functions to moderate the differentiation of macrophages into proinflammatory (M1) cells. PMID: 23742180
16. DNA methylation changes were noted in the Timp3 gene during chronic cystitis in a murine model. PMID: 23806407
17. Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II. PMID: 23144462
18. Loss of TIMP3 selectively exacerbates diabetic nephropathy. PMID: 22896043
19. Pericyte-derived TIMP3 stabilized and ADAMTS1 destabilized the capillary tubular networks PMID: 22383695
20. we show that TIMP3 produced by the hepatic stroma regulates the basal lymphocyte populations in the liver and prevents autoimmune hepatitis PMID: 22323541
21. Data suggest that focal ischemia leads to proliferation of immature oligodendrocytes in white matter and that TIMP-3 contributes to a caspase-3-dependent immature OL death via TNF-alpha/TACE-mediated neuroinflammation. PMID: 21871134
22. macrophage-specific overexpression of TIMP3 protects from metabolic inflammation and related metabolic disorders such as insulin resistance, glucose intolerance, and nonalcoholic steatohepatitis. PMID: 22228717
23. TIMP3 differentially impacts apoptosis and inflammatory cell influx, based on involvement of TNF, during the process of mammary involution. PMID: 22053204
24. macrophage-specific overexpression of TIMP3 decreases the inflammatory content and the amplitude of atherosclerotic plaques in low-density lipoprotein receptor knockout mice PMID: 22015660
25. Placental growth factor finely tunes a balanced regulation of the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-alpha-converting enzyme axis and the consequent TNF-alpha activation in response to transverse aortic constriction. PMID: 21900081
26. TIMP3 was identified as a potential miR-206 target by TargetScan prediction analysis; further, in cultured cardiac fibroblasts, miR-206 gain- and loss-of-function studies and luciferase reporter assays showed that TIMP3 is a direct target of miR-206. PMID: 21731608
27. deficiency in TIMP-3 increases cardiac rupture post-myocardial infarction PMID: 21243368
28. Timp3, an endogenous regulator of metalloproteinases, stimulates hematopoietic stem cells proliferation by recruiting quiescent hematopoietic stem cells into the cell cycle. PMID: 20798233
29. demonstrated that TNF signaling promoted hepatotoxicity, while excessive TNF receptor 1 (TNFR1) shedding in Timp3-/- mice was protective. PMID: 20628198
30. TIMP3 functions to promote the resolution of inflammation in the lung. PMID: 20008147
31. We have identified novel mechanisms, governed by the TACE-Timp3 interaction, involved in the determination of insulin resistance and liver steatosis during overfeeding in mice. PMID: 19877183
32. Overexpression of TIMP-3 can inhibit angiogenesis and associated tumor growth, and that the antiangiogenic effects of TIMP-3 appear to be mediated through the inhibition of functional capillary morphogenesis. PMID: 12384438
33. The gene expression and protein distribution of Timp-3 was analyzed during molar development. PMID: 12950084
34. TIMP-3 deficiency disrupts matrix homeostasis and the balance of inflammatory mediators, eliciting the transition to cardiac dilation and dysfunction. PMID: 15262835
35. Here we show that deletion of the mouse gene Timp3 resulted in an increase in TNF-alpha converting enzyme activity, constitutive release of TNF and activation of TNF signaling in the liver. PMID: 15322543
36. Timp3 has a role in diabetes and vascular inflammation through the insulin receptor and TNF-alpha PMID: 16294222
37. loss of TIMP3 impacts innate immunity by dysregulating cleavage of TNF and its receptors PMID: 16393953
38. TIMP-3 provides an inherent regulation over the kinetics of pro-MMP-2 processing, serving at a level distinct from that of TIMP-2 and TIMP-4 PMID: 16469749
39. TIMP-3 regulates MMP-2 activation to limit tumor cell extravasation and subsequent colonization of the lung, without augmenting inflammatory cell response. PMID: 16702949
40. Timp-3 plays an important role in the maintenance of renal macrostructure after unilateral ureteral obstruction PMID: 16778336
41. TIMP3 can indirectly regulate epithelial cell proliferation via MMP inhibitory activity. While others have demonstrated that TIMP3 controls proliferation in vitro, this is the first evidence of TIMP3 regulating proliferation in vivo. PMID: 16890932
42. TIMP3 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events. PMID: 17030988
43. Physiologically, Timp3(-/-) mammary glands displayed accelerated mammary ductal elongation during pubertal morphogenesis. PMID: 17327279
44. Results indicate that TIMP-3 deficiency results in mild cartilage degradation similar to changes seen in patients with osteoarthritis. PMID: 17328064
45. Laparotomy induced a downregulation of TIMP-3 and an upregulation of PI3-kinase, which increased cancer cell growth, invasion and cell cycle activity in comparison to laparoscopy. PMID: 17342361
46. The alveolar macrophage is essential for the TIMP-3 null sepsis-induced compliance alterations. PMID: 17586692
47. Timp-3 plays an important role in L-NAME-induced hypertension and myocardial vascular remodeling. PMID: 17664861
48. Role of DPPI and TIMP-3 in development of pulmonary fibrosis in early inflammation following bleomycin instillation. PMID: 17673693
49. TIMP-3 deficiency accelerated maladaptive cardiac remodeling after a myocardial infarction by promoting matrix degradation and inflammatory cytokine expression. PMID: 17945252
50. TIMP-3 facilitates Fas-mediated neuronal cell death following oxigen-glucose deprivation and plays a pro-apoptotic role in mild cerebral ischemia PMID: 17962815

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KEGG: mmu:21859

STRING: 10090.ENSMUSP00000020234

UniGene: Mm.4871