Recombinant Mouse Mitochondrial antiviral-signaling protein (Mavs), partial

1. Data show that interferon-beta promotor stimulator-1 (IPS-1) deficiency predisposed to severe pneumonia virus of mice (PVM) bronchiolitis. PMID: 28539639
2. MAVS deficiency is associated with allergic skin disease. PMID: 30249647
3. these data suggest that while MAVS signaling has a considerable impact on Treg identity, this effect is not mediated by intrinsic MAVS signaling but rather is likely an effect of the overproduction of pro-inflammatory cytokines generated in MAVS-deficient mice after WNV infection. PMID: 28094802
4. MAVS was identified as a main player in HDV detection and adaptive immunity was found to be involved in the amplification of the innate immune response. PMID: 28527664
5. MAVS is essential for spontaneous high basal expression of IFN-beta in cardiac myocytes and the heart. PMID: 28822807
6. findings suggest that oxidative stress-induced MAVS oligomerization in SLE patients may contribute to the type I IFN signature that is characteristic of this syndrome. PMID: 27899525
7. this study shows that keratinocytes are an important source of IFN-beta and MAVS is critical to this function, and demonstrates how the epidermis triggers unwanted skin inflammation under disease conditions PMID: 27438769
8. RIPK3 regulates type I IFN both transcriptionally, by interacting with MAVS and limiting RIPK1 interaction with MAVS, and post-transcriptionally. PMID: 28410401
9. Taken together, these results suggest that MAVS is essential for boosting optimal primary CD4(+) T cell responses upon NS4B-P38G West Nile virus vaccination and yet is dispensable for host protection and recall T cell responses during secondary wild-type West Nile virus infection. PMID: 28077630
10. this study demonstrates that the capacity of hepatitis A virus to evade MAVS-mediated type I interferon responses defines its host species range. PMID: 27633528
11. Hepatitis C virus NS3-4A inhibits the peroxisomal MAVS-dependent antiviral signaling response. PMID: 26865163
12. An autoinhibitory mechanism modulates MAVS activity in unstimulated cells and, on viral infection, individual regions of MAVS are released following MAVS filament formation to activate antiviral signalling cascades. PMID: 26183716
13. indicate comparable activation of the IFN response by pex- and mito-mitochondrial antiviral-signaling protein in hepatocytes and efficient counteraction of both MAVS species by the HCV nonstructural protein 3 protease PMID: 26588843
14. Transmembrane motif T6BM2-mediated TRAF6 binding is required for MAVS-related antiviral response. PMID: 26385923
15. Data show that intracellular adaptor protein Cardif-/- natural killer cells (NK cells) are more apoptotic and less proliferative. PMID: 26232430
16. Elucidate the structural mechanism of MAVS polymerization, and explain how an alpha-helical domain uses distinct chemical interactions to form self-perpetuating filaments. PMID: 24569476
17. MAVS plays an essential role in host immunity against metapneumovirus infection. PMID: 25953917
18. results indicate that Lyn plays a positive regulatory role in RIG-I-mediated interferon expression as a downstream component of IPS-1 PMID: 25585356
19. In lung epithelial cells, retinoic acid-inducible gene-1 (RIG-I) was identified as the major RIG-I-like receptor required for RSV-induced protease expression via MAVS. PMID: 25005357
20. This study has identified a previously unrecognized role of MAVS in the regulation of inflammasome signaling PMID: 25847972
21. These results establish a dominant protective role for MAVS, IRF-3 and IRF-7, and IFNAR in restricting Oropouche virus infection and tissue injury and suggest that IFN signaling in nonmyeloid cells contributes to the host defense. PMID: 25717109
22. findings demonstrate that IFN-beta, but not IFN-lambda2/3, produced via an IPS-1-IRF3 signaling pathway, is important for hMPV clearance. PMID: 24726644
23. Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis. PMID: 24743949
24. that Smurf2 is an important nonredundant negative regulator of virus-triggered type I IFN signaling by targeting VISA for K48-linked ubiquitination and degradation. PMID: 24729608
25. Data indicate that IPS-1-dependent pathway plays a crucial role in type III IFN production by CD8(+) dendritic cells (DCs) and hepatocytes in response to hepatitis C virus (HCV), leading to cytoplasmic antiviral protein expressions. PMID: 24532585
26. In virus-infected cells, a Bax/Bak-independent pathway involves dsRNA-induced innate immune signaling via mitochondrial antiviral signaling (MAVS) and caspase-8. PMID: 24391214
27. MAVS participates in the initial induction of type I IFN in bone marrow-derived dendritic cells and IFNAR protects against MV spreading. PMID: 24096085
28. data suggest that IPS-1 plays a dual function in inducing murine melanoma B16F10 cell apoptosis PMID: 23784981
29. MAVS binds to voltage-dependent anion channel 1 (VDAC1) and induces apoptosis by caspase-3 activation, which is independent of its role in innate immunity. PMID: 23754752
30. La Crosse virus infection induced the RNA helicase, RIG-I, and mitochondrial antiviral signaling protein (MAVS) signaling pathway, resulting in upregulation of the sterile alpha and TIR-containing motif 1 (SARM1), an adaptor molecule that we found to be directly involved in neuronal damage PMID: 23499490
31. IPS-1 is essential for protection and control of an attenuated Sindbis virus. PMID: 23084425
32. Viral clearance and inflammation resolution are strongly affected by the absence of an initial IPS-1-mediated interferon (IFN)-beta response. PMID: 23136205
33. novel residue of MAVS that is crucially involved in the recruitment of TRAF3/TRAF6 and in downstream propagation of MAVS signaling PMID: 22844514
34. UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction. PMID: 22131337
35. Bone marrow transplantation experiments revealed that MAVS in cells of nonhematopoietic origin plays a dominant role in the protection against colitis. PMID: 21960441
36. found that PB1-F2 inhibited IFN production at the level of the mitochondrial antiviral signaling protein PMID: 21695240
37. Viral infection induces the formation of very large MAVS aggregates, which potently activate IRF3 in the cytosol; results suggest that a prion-like conformational switch of MAVS activates and propagates the antiviral signaling cascade. PMID: 21782231
38. Regulation of Igh-1b (RIG-I) or melanoma differentiation-associated (MDA)5 signaling through MAVS is required for activation of interferon (IFN)-beta production by rotavirus-infected intestinal epithelium. PMID: 21187438
39. these results showed that conjunctival epithelial cells express RIG-I and MDA5, and IPS-1, an adaptor molecule common to RIG-I and MDA5, contributes to polyI:C-inducible cytokine production in conjunctival epithelial cells. PMID: 21130742
40. gammaHV68 hijacks the antiviral MAVS-IKKbeta pathway to promote viral transcription and lytic infection, whereby viral replication is coupled to host immune activation PMID: 20686657
41. IPS-1 is essential for both bone marrow derived DC activation and IFN production in rabies PMID: 20661430
42. Our data define an innate/adaptive immune interface mediated through IPS-1-dependent RIG-I-like receptor signaling in response to West Nile virus infection PMID: 20140199
43. show that interferon-beta promoter stimulator 1 (IPS-1) binds DAP3 and induces anoikis by caspase activation. PMID: 19644511
44. The overexpression of mitochondrial antiviral signaling(MAVS)induces the expression of IFN-beta through activation of NF-kappaB and IRF 3, thus boosting antiviral immunity. PMID: 16125763
45. Data suggest that VISA is critically involved in both virus-triggered TLR3-independent and TLR3-mediated antiviral interferon signaling. PMID: 16153868
46. IPS-1 is the sole adapter in both retinoic acid-inducible gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5) signaling that mediates effective responses against a variety of RNA viruses. PMID: 16785313
47. These results define IPS-1-dependent signaling as an essential feature of host immunity to RNA virus infection. PMID: 17942531
48. RIG-1 - MAVS interacts with cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I - NF- kappa B-inducing kinase signaling pathway PMID: 18550535
49. provide an example of a normal and effective adaptive immune response in the absence of innate immunity mediated by MAVS and MyD88 PMID: 18780793
50. Upon Sendai virus (SeV) infection, TBK1s is induced in both human and mouse cells and binds to RIG-1, disrupting the interaction between RIG-I and VISA PMID: 18977754

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KEGG: mmu:228607

STRING: 10090.ENSMUSP00000038339

UniGene: Mm.287226