Recombinant Mouse Mitogen-activated protein kinase kinase kinase 14 (Map3k14), partial

1. Pathological activation of hepatic NIK likely blocks hepatocyte replication, contributing to liver disease progression. PMID: 30070632
2. Nik(-/-) mice could be useful as a spontaneous model of specific features of Eosinophilic esophagitis. PMID: 29259025
3. global or thymus-specific ablation of the NIK gene results in fatal autoimmune liver disease in mice. PMID: 28267623
4. These findings highlight the importance of NIK in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK and Drp1. PMID: 27889261
5. constitutive activation of NIK in the hematopoietic system leads to bone marrow (BM) failure and postnatal lethality. PMID: 27733012
6. results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100. PMID: 27678221
7. NIK pathways in both hepatocytes and immune cells act in concert to promote liver steatosis and glucose production in the setting of obesity. PMID: 28379340
8. this study demonstrates that although NIK is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells PMID: 26912039
9. Using a novel conditional mutant of NIK, the authors could show in vivo that NIK signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production. PMID: 26637788
10. NIK not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1/RIP1-dependent cell death independently of the alternative NF-kappaB pathway. PMID: 26045047
11. This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS. PMID: 26778773
12. results assign NIK-induced alternative NF-kappaB signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined PMID: 26593098
13. Deletion of NIK in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF. PMID: 26116508
14. We identify NIK as a critical negative regulator of beta cell function, as pharmacological NIK activation results in impaired glucose-stimulated insulin secretion in mouse and human islets. PMID: 26122662
15. the NIK in thymic stroma may be critically involved in the differentiation of most NKT cell subsets (although the level of NIK dependence may vary among the subsets), and also the NIK in NKT-alphabeta cells may be dispensable for their effector function. PMID: 25988531
16. CHIP/TRAF3/NIK interactions recruit NIK to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK at low levels PMID: 25792747
17. The results suggest a pivotal role of NIK in the thymic stroma in establishing self-tolerance by orchestrating cross-talk between medullary thymic epithelial cells and dendritic cells as well as thymocytes. PMID: 25261487
18. These studies provide evidence for a role of NF-kappaB-inducing kinase (NIK) and subsequent non-canonical NF-kappaB signalling in pathological angiogenesis PMID: 25043127
19. Our results therefore establish that the negative feedback control of IKKalpha-mediated NIK turnover occurs via a novel proteasome-dependent and cIAP-independent mechanism. PMID: 24942881
20. The role of Peyer's patches and/or mesenteric lymph nodes in bacterial translocation was evaluated in mice deficient for both due to a mutation of NF-kappa B-inducing kinase. PMID: 24745143
21. Results show that nuclear factor-kappa B inducing kinase has a role in graft-versus-host disease by maintaining the viability of activated alloreactive T lymphocytes. PMID: 20823135
22. NIK could be involved in thymic positive selection of some alphabeta T cells and that NIK in non-haematopoietic cells is important for the optimal development and/or maintenance of gammadelta T cells. PMID: 24117043
23. These results demonstrate a cell-intrinsic requirement for NIK in the generation and/or maintenance of memory T cells in response to acute viral infection. PMID: 24006459
24. IKKalpha and its activator, NF-kappaB-inducing kinase (NIK), support the expansion of tumor-initiating cells. PMID: 23602409
25. ATP consumption and peptide phosphorylation assays confirm that phosphorylation of NIK does not increase enzymatic activity. PMID: 22921830
26. overactivation of liver NIK in obesity promotes hyperglycemia and glucose intolerance by increasing the hyperglycemic response to glucagon and other factors that activate CREB. PMID: 22581287
27. Results suggest a possible role of NIK in the liver and renal tissues of insulin-resistant mice. PMID: 22340218
28. NIK activity in nonhematopoietic cells controls Th2 cell development and prevents eosinophil-driven inflammatory disease, most likely using a signaling pathway that operates independent of the known NIK substrate IKKalpha. PMID: 22474019
29. NIK was not needed for antigen receptor signaling. It was required for costimulation via OX40. Conditional overexpression of NIK in T cells caused rapid, fatal autoimmunity with hyperactive effector T cells & poorly suppressive Foxp3(+) Tregs. PMID: 22045568
30. Cigarette smoke and TNFalpha increase NIK levels causing phosphorylation of IKKalpha, which leads to histone acetylation. PMID: 21887257
31. a population of thymic DCs requires NIK to shape the formation of most alphabeta CD4(+) T effector lineages during early development. PMID: 21807870
32. Data show that OC-specific NIK lacking its TRAF3 binding domain (NT3) transgenic mice have an exaggerated osteolytic response to arthritis. PMID: 21151480
33. Lipopolysaccharide induces activation of both canonical and non-canonical pathways of NF-kappaB and the non-canonical pathway requires phosphorylations of BCL10 (serine 138) and NIK. PMID: 20466000
34. NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells. PMID: 18663224
35. A role is established for NIK in Nod2-dependent signaling. PMID: 16552041
36. the degradation of NIK occurs upon assembly of a regulatory complex through TRAF3 recruitment of NIK and TRAF2 recruitment of cIAP1 and cIAP2 PMID: 18997794
37. These findings indicate an upstream signaling role for BCL10, in addition to its effects on IKKgamma, the regulatory component of the IKK signalosome, and a requirement for BCL10 in both canonical and noncanonical pathways of NF-kappaB activation. PMID: 19897484
38. results suggest critical roles for NIK in setting the threshold for T cell activation, and partly account for the immunodeficiency in aly mice. PMID: 12133934
39. Results show that NF-kappa B-inducing kinase is necessary for RelB activation upon triggering of surface receptors. PMID: 12810685
40. NIK plays an essential role in the organization of the thymic microenvironment that is required for the establishment of self-tolerance. PMID: 14764671
41. Nuclear factor-inducing kinase plays a role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation PMID: 15247285
42. While Nik-/- mice had inflammation equivalent to that of Nik+/+ controls, they showed significantly less periarticular osteoclastogenesis and less bone erosion. PMID: 15937549
43. NIK plays a pivotal role in controlling the development and expansion of CD4+CD25+ regulatory T (Treg) cells. PMID: 16034105
44. a novel role for NIK as a histone H3 modifierin in the endotoxin response through modification of nucleosomal structure. PMID: 16675465
45. NIK acts as crucial regulator in MMP-9 activation thereby controlling melanoma cell motility and chemoinvasion PMID: 16691505
46. deregulation of the canonical NF-kappaB pathway in TRAF3-deficient cells results from accumulation of NF-kappaB-inducing kinase PMID: 18292232
47. NIK in stromal cells has a specific role in the regulation of S1P-mediated trafficking of peritoneal B ce PMID: 18292290
48. The absence of functional NIK impairs primary HTLV-1 proliferation and abolishes the maintenance of provirus. PMID: 18312467
49. Deletion of p100 restores the capacity of NIK-deficient osteoclast (OC) precursors to differentiate and normalizes RelB and p65 signaling. PMID: 18322009
50. NIK mediates synergistic activation of STAT3 by T-cell receptor and IL-6 receptor signals.NIK as an important signaling factor that regulates Th17 differentiation and experimental autoimmune encephalitis induction. PMID: 19411637

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KEGG: mmu:53859

STRING: 10090.ENSMUSP00000021324

UniGene: Mm.158981