Recombinant Mouse Mitogen-activated protein kinase kinase kinase 5 (Map3k5), partial

1. Findings offer insight into positive regulation of Akt signaling through P2Y12 phosphorylation as well as MAPK signaling in platelets by ASK1. PMID: 28753204
2. This study demonstrated that the first evidence suggesting that ASK1 may play some role in the pathophysiology of Alzheimer's Disease and brain aging. PMID: 29154282
3. Oxidative and endoplasmic reticulum stress-dependent ASK1 activation in steatotic hepatocytes and Kupffer cells sensitizes mice fatty liver to ischemia/reperfusion injury. PMID: 28739531
4. The results of this investigation indicate ASK1 inhibition prolongs keratinocyte and blastemal cell activation leading to ear regeneration. PMID: 29045420
5. These results suggest that the platelet Ask1 plays an important role in regulation of hemostasis and thrombosis. PMID: 28028021
6. These results demonstrate that trans-fatty acids promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of trans-fatty acids-induced atherosclerosis. PMID: 28360100
7. Conversely, treatment with LY294002 (a selective inhibitor of Akt1) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future. PMID: 27450812
8. ASK1 MAP kinase signaling cascade is an important regulator of chondrocyte terminal differentiation. PMID: 26405834
9. ASK1 mediates astrocyte activation and leads to glial scar formation after cerebral ischaemia. PMID: 26797817
10. ASK1 mediates 3-NP toxicity and regulates C1q level through the astrocyte TGF-beta. PMID: 26728245
11. ASK1 signalling regulates brown and beige adipocyte function. PMID: 27045525
12. ASK1 deletion in vivo significantly suppresses hyperoxia-induced elevation of inflammatory cytokines (i.e. IL-1beta and TNF-alpha), cell apoptosis in the lung, and recruitment of immune cells PMID: 26807721
13. data highlight the importance of ASK1/p38 MAPK pathway in the brain and identify Klotho as a possible anti-oxidant effector PMID: 26452228
14. Data show that deletion of either MAPKKK5 ASK1 or MAPKKK6 ASK2 in mice promoted the replication of influenza A virus in the lung. PMID: 26243192
15. Our results provided the evidence that high-fat diet itself causes cognitive impairment and ASK1 participates in such cognitive impairment. PMID: 26044555
16. ASK1 may mediate the teratogenicity of diabetes through activating the JNK1/2-ER stress pathway and inhibiting cell cycle progression, thereby impeding the cardiogenesis pathways essential for ventricular septation and outflow tract development. PMID: 26173459
17. Study demonstrates that ASK1 is not involved in beta-cell function and dysfunction but controls stress-induced beta-cell death. PMID: 25383781
18. ASK1 in sensitized CD41 T cells appears to play a major role in CHS by facilitating IL-17 production. PMID: 24736726
19. Because the phosphorylation site mutants of NR4A2 cannot rescue the cell death-promoting activity, ASK1-p38 pathway-dependent phosphorylation and subsequent cytoplasmic translocation of NR4A2 may be required for oxidative stress-induced cell death. PMID: 25752609
20. Flip preserves cardiac functions and inhibits cardiac hypertrophy partially by blocking ASK1/P38 signaling. PMID: 25087120
21. Inhibition of ASK1 enhances endochondral bone formation by increasing chondrocyte survival. PMID: 25393478
22. ASK1 inhibition reduced apoptosis and reduced mitochondrial reactive oxygen species generation in cardiac hypertrophy. PMID: 25628390
23. Data show that ASK1 plays a causal role in diabetes-induced ER stress and apoptosis. PMID: 25249581
24. ASK1 is an important upstream activator of p38 and JNK signaling in the obstructed kidney PMID: 25298527
25. Chop and Ask1 do not regulate rod survival or retinal degeneration directly but may be involved in regulating secondary pathological responses such as inflammation that are upregulated during later stages of disease progression PMID: 24523853
26. The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling PMID: 24938188
27. ASK1 knockout and ASK1-inhibited mice were protected from cognitive decline due to bilateral common carotid stenosis. The oxidative stress-ASK1-p38 cascade impairs cognition by disrupting endothelial tight junctions in the blood-brain barrier. PMID: 24371084
28. Data indicate that ASK1 activation stimulated the activity of the transcription factor FoxO3a, which increased the abundance of the apoptosis-promoting adaptor protein TRADD, leading to activation of caspase 8. PMID: 23982205
29. ASK1 regulates neurogenesis after ischemic brain injury through the p38 MAP kinase pathway. PMID: 24357833
30. The present study suggests that ROS-inducing ASK1 may be an important step in the pathogenesis of 3-NP infused striatal lesions in murine brains. PMID: 24021285
31. The ASK1 signaling pathway regulates the OVA-induced asthmatic phenotype, specifically airway hyperreactivity sensitivity and cytokine production PMID: 23921222
32. ER stress-induced ASK1-p38 activation, which is triggered by the accumulation of Ins(C96Y), plays an important role in the pathogenesis of diabetes. PMID: 23416061
33. ASK1 accelerates mechanical injury-induced vascular remodeling with activated smooth muscle cell migration. PMID: 23178077
34. Injection of vectorised miR-20a mimics to mice led to a global decrease in ASK1 protein expression. PMID: 23087182
35. ASK-1 is an important regulator of lung injury and apoptosis PMID: 22052879
36. ASK1 and TAK1 function as MAP3 kinases in Cdo-mediated p38MAPK activation to promote myogenic differentiation. PMID: 22337877
37. ASK1 is an important effector of MPTP-induced toxicity. PMID: 22253830
38. TAK1 and its adapter protein, TAB2, reciprocally regulate both TAK1- and ASK1-mediated signaling pathways to direct the activations of NF-kappaB and AP-1. PMID: 22167179
39. Our results suggest the increased Ask1 expression induce apoptotic cell death after ischemia/reperfusion. PMID: 21803338
40. Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase. PMID: 21488081
41. Suggest that ASK1 suppresses hyperlipidemia-induced atherosclerosis via increased macrophage apoptosis and that ASK1 may cause pronounced plaque vulnerability via necrotic core development. PMID: 21527753
42. ASK1 is implicated in cardiac inflammation and fibrosis, and vascular endothelial dysfunction caused by high-salt diet, through the enhancement of oxidative stress PMID: 20935579
43. results suggest that ASK1 activation is involved in normal tension glaucoma-like pathology in both neural and glial cells PMID: 20489729
44. Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer PMID: 21187402
45. ASK1 may be critical for the development of rheumatoid arthritis (RA) and ASK1 may be involved in the production of proinflammatory mediators in response to TNF-alpha stimulation in the RA joint. PMID: 20609399
46. the induction of myostatin by trichostatin A treatment in myocytes is in part through ASK1-MKK3/6-p38 MAPK and ASK1-MKK4-JNK signaling pathways. Activation of p38 MAPK and JNK axis is necessary, but not sufficient for TSA-induced myostatin expression. PMID: 20568119
47. The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging. PMID: 20844314
48. Our findings thus demonstrate novel behavioral functions of ASK1, including regulation of locomotor activity, novelty preference, and motor coordination with dopaminergic transmission. PMID: 20006657
49. ASK1 controls the development of intestinal inflammation and colitis-associated tumorigenesis through the regulation of innate immunity. PMID: 19931259
50. Activation of ASK1 largely co-localizes with TNFR1, and activation of Etk largely co-localizes with TNFR2 in vascular endothelium cells and cardiomyocytes. PMID: 19788501

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KEGG: mmu:26408

STRING: 10090.ENSMUSP00000093485

UniGene: Mm.6595