Recombinant Mouse Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (Malt1), partial

1. this study shows that Malt1 protease activity plays an important role in the activation of innate immune cells via FcgammaR, and the development of FcgammaR-mediated autoimmune diseases PMID: 29414650
2. the importance of MALT1-mediated inflammation and T cell activation to control ERA virus, providing new insights in the biology of MALT1 and rabies virus infection. PMID: 29367251
3. MALT1 as a key molecule that contributes to immune tolerance at steady-state while facilitating immune reactivity under stress conditions. PMID: 26405015
4. MALT1 function is required in B cells for germinal center formation. PMID: 28031341
5. Studies indicate an important role for mucosa associated lymphoid tissue lymphoma translocation gene 1 protein (MALT1) in the development of experimental autoimmune encephalomyelitis (EAE) PMID: 26386283
6. Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review) PMID: 26787500
7. TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation. PMID: 27068814
8. MALT1-dependent NF-kappaB activation is crucial for the development of EGFR-associated solid-tumor progression PMID: 25982276
9. By regulating linear ubiquitination, MALT1 is both a positive and negative pleiotropic regulator of the canonical NF-kappaB pathway. PMID: 26525107
10. Results demonstrate that MALT1 protease activity plays key roles in both innate and adaptive immune responses, and in regulating immune homeostasis in vivo. PMID: 25965667
11. data demonstrate that MALT1 ubiquitination is critical for the engagement of CBM and IKK complexes, thereby directing platelet signals to the NF-kappaB pathway. PMID: 25748427
12. Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity. PMID: 25319413
13. These results reveal distinct threshold and modulatory functions of Malt1 that differentially control lymphocyte differentiation and activation pathways. PMID: 25456129
14. Trehalose 6,6'-dimycolate-induced Mincle expression is dependent on Dectin-3-mediated NF-kappaB activation through the CARD9-BCL10-MALT1 complex. PMID: 25202022
15. Upon recognition of antigen by the T cell antigen receptor (TCR), roquin and regnase-1 proteins were cleaved by the paracaspase MALT1. PMID: 25282160
16. TCR-stimulated activation of NF-kappaB requires the assembly of cytosolic p62-Bcl10-Malt1-IKK signalosomes, which may ensure highly regulated activation of NF-kappaB in response to TCR engagement. PMID: 24825920
17. MALT1-knockout mice do not develop any clinical symptoms of experimental autoimmune encephalomyelitis; MALT1-deficient effector T cells are unable to induce demyelinating inflammation in the central nervous system. PMID: 23401595
18. MALT1 is a central, cell-intrinsic factor that determines the encephalitogenic potential of inflammatory Th17 cells in vivo. PMID: 23114599
19. work establishes a molecular link between MALT lymphoma and ABC-DLBCL, and provides mouse models to test MALT1 inhibitors. Finally, our results suggest that hematopoietic stem/progenitor cells may be involved in the pathogenesis of human B-cell lymphomas PMID: 22689981
20. Authors provide biochemical and structural evidence that MALT1 activation is dependent on its dimerization and show that mutations at the dimer interface abrogate activity in cells. PMID: 22366302
21. findings demonstrate that primary T and B lymphocytes from paracaspase (MALT1)-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation PMID: 14576442
22. Malt1 is an essential positive mediator of IgE receptor Fc epsilon RI-dependent mast cell activation that selectively uncouples NF-kappa B-induced proinflammatory cytokine production from degranulation and leukotriene synthesis. PMID: 16432253
23. Data show that IRAK-1 acts as the essential upstream adaptor that recruits BCL10 to the TLR4 signaling complex and mediates signaling to NF-kappaB through the BCL10-MALT1-TRAF6-TAK1 cascade. PMID: 16831874
24. Bcl10 and Malt1 control lysophosphatidic acid-induced NF-kappaB activation and cytokine production. PMID: 17095601
25. both Bcl10 and Malt1 are essential for TCR signaling in thymocytes as a genetic disruption of either molecule blocks TCR-induced NF-kappaB activation in these cells PMID: 17202357
26. Bcl-10 and MALT1 differentially regulated B cell receptor-induced activation of RelA and c-Rel. PMID: 17660823
27. Proliferative defects of CD4-positive T cells from caspase-like protein Malt1-deficient mice are primarily due to failure to activate NF-kappa B in response to T cell receptor ligation, whereas NF-KB activation in CD8+ T cells is independent of Malt1. PMID: 18941215
28. a novel role for MALT1 in biological outcomes induced by BAFF-mediated signal transduction. PMID: 19917778

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KEGG: mmu:240354

STRING: 10090.ENSMUSP00000048376

UniGene: Mm.132613