Product Details

Purity

>85% (SDS-PAGE)

Target Names

Myh14

Uniprot No.

Q6URW6

Alternative Names

Myh14; Myosin-14; Myosin heavy chain 14; Myosin heavy chain; non-muscle IIc; Non-muscle myosin heavy chain IIc; NMHC II-C

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.

Gene References into Functions

that Myh14 may play a beneficial role in the protection of the cochlea after acoustic overstimulation in CBA/CaJ mice PMID: 28101381
we have validated a novel gene, Myh14, as a negative regulator of ISO-induced left ventricular mass hypertrophy in an in vivo mouse model and demonstrated the up-regulation of immediate early gene Myc, fetal gene Nppb, and fibrosis gene Lgals3 in ISO-treated Myh14 deficient hearts compared to controls. PMID: 27385019
NM II-C1C2 may be involved in stabilizing neurites by maintaining their structure at adhesion sites PMID: 23355468
Data indicate that when both NM II-C and II-B are ablated the B-C-/B-C- cardiac myocytes show major defects in karyokinesis. PMID: 20861308
This study provides molecular insight into the role of the structurally disordered tailpiece of non-muscle myosin IIC (NMII-C) in shifting the oligomeric equilibrium of NMII-C toward filament assembly and determining its morphology. PMID: 19959848
a cGMP-independent mechanism for nitric oxide-mediated inhibition of nonmuscle myosin heavy chain II-C induction PMID: 12598534
mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C PMID: 15845534
the alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation PMID: 19240025
myosin II, directly regulates cellular patterning and alignment within the cochlear sensory epithelium PMID: 19439495

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Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family

Tissue Specificity

Highest levels in lung, kidney, brain and colon, very low levels in liver and bladder and no expression in spleen or seminal vesicle (at protein level). Isoform 1 is expressed in liver, kidney and testis with low levels in skeletal muscle and heart. Isofo

Database Links

KEGG: mmu:71960

STRING: 10090.ENSMUSP00000103531

UniGene: Mm.158289

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Recombinant Mouse Myosin-14 (Myh14), partial

Product Details

Customer Reviews and Q&A

Target Background

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