Recombinant Mouse Natural cytotoxicity triggering receptor 1(Ncr1),partial

Code CSB-YP015549MO
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Source Yeast
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Code CSB-EP015549MO
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Source E.coli
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Code CSB-EP015549MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP015549MO
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Source Baculovirus
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Code CSB-MP015549MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ncr1
Uniprot No. Q8C567
Alternative Names Ncr1; Ly94; Natural cytotoxicity triggering receptor 1; Activating receptor 1; mAR-1; Lymphocyte antigen 94; Natural killer cell p46-related protein; NK-p46; NKp46; mNKp46; CD antigen CD335
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Gene References into Functions
  1. Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral natural killer cells PMID: 29329948
  2. these studies strongly support roles for NCR1 and its ligands in normal pregnancy promotion PMID: 28098245
  3. Ly49E-positive population is negative for NKp46 and CD8alphaalpha, expresses CD49a and CD103, and requires T-bet expression and IL-15 signaling for differentiation and/or survival. PMID: 28514662
  4. this study demonstrates the role of NCR1 in antibody response to mouse cytomegalovirus infection PMID: 28643847
  5. Our findings uncover a detrimental role of T-bet-dependent NKp46(+) ILCs in the development of CNS autoimmune disease. PMID: 28805812
  6. The results identify an unexpected phenotypic instability within NKp46(+) ILC3 that suggests a major role for environmental signals in tuning ILC3 functional plasticity. PMID: 27183613
  7. The authors delineated the fungal ligands to be the Candida glabrata adhesins Epa1, Epa6, and Epa7 and demonstrated that clearance of systemic Candida glabrata infections in vivo depends on their recognition by mouse NCR1. PMID: 27736647
  8. it is demonstrated that NCR1 dampens allergic eosinophilic airway inflammation. PMID: 27580126
  9. this study using Ncr1-deficient mice, shows that NCR1 plays a critical role in controlling human metapneumovirus infection PMID: 28191644
  10. Rag knockout mice that possess fully functional NKp46(+) cells PMID: 26341825
  11. Ncr1-Noe proteins accumulate in the endoplasmic reticulum, and that the expression of Ncr1-Noe proteins, but not WT Ncr1, leads to increased Helios expression PMID: 26371250
  12. NK cell receptor NKp46 regulates graft-versus-host disease. PMID: 24882008
  13. Ifnar1(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack. PMID: 24909889
  14. Data from knockout/transgenic mice suggest that activation of Ncr1 by endogenous (as yet undefined) ligands contributes to activation/maturation of uterine natural killer cells and likely makes critical contributions to implantation/placentation. PMID: 23806179
  15. Here, we demonstrate the regulation of T-cell mediated allergic responses, which is dependent on the NK-cell specific receptor NKp46 (Ncr1 in mice). PMID: 23878025
  16. NKp46 deficiency alone, or in combination with NKG2D deficiency, had no effect on frequency or function of NK cells PMID: 23649470
  17. NCR1 and NKp46 directly recognize a periodontal pathogen. PMID: 22457623
  18. NKp46/NCR1 plays an important role in controlling neoplasm metastasis PMID: 22308311
  19. downregulation of NK activity by NKp46 associated with silencing of Helios in NK cells; NKp46 critical for development of antiviral and antibacterial T cell response PMID: 22267813
  20. Fate mapping experiments demonstrated the stable expression of NKp46 on NK cells and allowed a reappraisal of the sequential steps of NK cell maturation PMID: 22021440
  21. The presence of the NCR1 receptor is imperative for the early clearance of S. pneumoniae. PMID: 21887255
  22. we investigated the molecular mechanisms controlling NKp46 interactions with its beta cell ligand and demonstrate that the recognition is confined to the membrane proximal domain and stalk region of NKp46 PMID: 21849674
  23. NKp46 identifies a functionally distinct NKT subset in that appears to be directly susceptible to leukemic transformation when IL-15 is overexpressed. PMID: 21364281
  24. IL-12 initiated local antitumor immunity by stimulating a subset of NKp46(+) lymphoid tissue-inducer (LTi) cells PMID: 20935648
  25. In vivo growth of 3-methylcholanthrene-derived tumor cells expressing high levels of NKp46 ligands is NKp46 and interferon-gamma dependent. PMID: 20404273
  26. NKp46 is essential for the development of type 1 diabetes PMID: 20023661
  27. NKp46 interacts with both viral hemagglutinins and the unknown tumor ligands via different mechanisms. PMID: 14504081
  28. Mouse NKp46 triggers Natural Killer cell effector function and allows the detection of NK cells in situ. PMID: 17360655
  29. a crucial role for NKp46/NCR1 in the in vivo eradication of some lymphoma cells. PMID: 19201876
  30. NKp46 plays a redundant role in the differentiation of intestinal IL-22(+) cells that mediate innate defense against Citrobacter rodentium PMID: 19846871

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Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Natural cytotoxicity receptor (NCR) family
Tissue Specificity Selectively expressed by NK cells.
Database Links

KEGG: mmu:17086

STRING: 10090.ENSMUSP00000006792

UniGene: Mm.240231

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