Recombinant Mouse Neural Wiskott-Aldrich syndrome protein (Wasl)

1. N-WASP regulates cortical neuron migration mainly through its polyPro and VCA domains. PMID: 29785947
2. It has been shown in a genetic psoriasis model that N-WASP controls IL-23 expression in keratinocytes by regulating the degradation of the histone methyltransferases G9a and GLP, and H3K9 dimethylation of the IL-23 promoter. PMID: 29650963
3. Wound healing was faster in N-WASP(FKO) compared to controls, and N-WASP deficient fibroblasts were found to have enhanced collagen gel contraction properties. These results suggest that N-WASP deficiency in fibroblasts improves wound healing by growth factor-mediated enhancement of keratinocyte proliferation and increased wound contraction. PMID: 27909303
4. Myogenic differentiation depends on the expression regulation patterns of Grb2 and N-WASP. PMID: 27965114
5. Data (including data from studies in knockout mice) suggest that Cnr1 (cannabinoid receptor 1) activation impacts actin cytoskeleton polymerization/stability via Wasl in growth cones of developing neurons and in synaptic spines of mature neurons. PMID: 26496209
6. Our data suggests that the N-WASP-Arp2/3 actin polymerization machinery generates branched-actin arrays at an advanced stage of blood-testis barrier remodeling. PMID: 24967734
7. N-terminus of Cas associates with the FAK-N-WASP complex at the protrusive edge of the cell and that the C-terminus of Cas associates with the immobilized integrin-SFK cluster. PMID: 24481817
8. Toca-1(knockdown) cells have defects in formation of myotubes probably due to reduced activity of actin cytoskeleton regulators such as N-WASP. PMID: 24861867
9. N-WASP plays a unique role in the down-regulation of BCR signaling at the cell surface. PMID: 24223520
10. Our results suggest that N-WASP plays a critical role in normal brain development and implicate actin cytoskeleton regulation as a vulnerable axis frequently deregulated in hydrocephalus. PMID: 24462670
11. These findings elucidate how junctional actin dynamics via Cdc42/N-WASP signaling cell-autonomously control not only epithelial delamination but also cell differentiation during mammalian organogenesis. PMID: 24449844
12. actin dynamics regulated by the balance of N-WASP and cofilin activities determines the biphasic response of GIIS. PMID: 23867458
13. Using mouse embryonic fibroblasts lacking Nck, WIP, or N-WASP, this study investigated whether an interaction of Nck with both WIP and N-WASP is required for their recruitment to vaccinia during Arp2/3-dependent actin assembly. PMID: 23707428
14. N-WASP-mediated actin nucleation of branched microfilament networks is specifically required for the maintenance of foot processes. PMID: 23471198
15. These data highlight similar pathogenic strategies shared by EPEC and vaccinia virus by demonstrating a requirement for both Nck and N-WASP, but not WIP or WIP family members in pathogen-induced actin assembly. PMID: 22966049
16. Nck and Cdc42 co-operate to recruit N-WASP to promote FcgammaR-mediated phagocytosis. PMID: 22454526
17. This study supports a critical role of N-WASP in integrating FAK and Arp2/3 signaling to mediate formation of alpha-SMA-containing cytoplasmic filaments during myofibroblast differentiation and maturation. PMID: 22886502
18. N-WASp is an actin regulator required for muscle-cell fusion in mice PMID: 22736793
19. Paxillin and N-WASP are involved in the reorganization of actin cytoskeleton driving motility of LPS-stimulated cells. PMID: 21898535
20. beta1 integrins regulate fibroblast chemotaxis through control of N-WASP stability. PMID: 21427700
21. Our observations demonstrate that N-WASp plays an essential role in Schwann cell maturation and myelin formation. PMID: 21385763
22. The regulation of actin filament nucleation in Schwann cells by N-WASP is crucial for membrane wrapping, longitudinal extension, and myelination. PMID: 21263026
23. In macrophages, many of the defects associated with the loss of WASP, such as podosome-dependent matrix degradation and chemotaxis were corrected when N-WASP was expressed at equimolar level to that of the wild-type WASP. PMID: 20599953
24. findings show the nebulin-N-WASP complex caused actin nucleation for unbranched actin filament formation from the Z bands without the Arp2/3 complex; N-WASP was required for IGF-1-induced muscle hypertrophy PMID: 21148390
25. Gas7 works through its interaction with N-WASP during neuronal maturation/ differentiation PMID: 20150425
26. Conditional knockout approach to assess the role of neural Wiskott-Aldrich syndrome Wasl protein in mouse skin. PMID: 20071778
27. Results show that DIP/WISH binds to mammalian diaphanous and N-WASP, and functions as a scaffold protein by binding to Nck protein. PMID: 19778379
28. This protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor. PMID: 12477732
29. the function and localization of N-WASP in the cytoplasm are regulated by FBP11 PMID: 14697212
30. N-WASP and the Arp2/3 complex trigger actin polymerization during a late step in clathrin-mediated endocytosis PMID: 15085951
31. Erk phosphorylation liberates the SH3 domain of cortactin from intramolecular interactions with proline-rich regions, causing it to synergize with WASP and N-WASP in activating the Arp2/3 complex PMID: 15169891
32. results imply that both N-WASP and WAVE2 proteins, which are activated downstream of phosphati-dylinositol 3-kinase, are required for the migration through the lamellipodial formation of myocyte C2C12 cells induced by hepatocyte growth factor PMID: 15496413
33. Cortactin regulates cell movement through activation of N-WASP. PMID: 15585574
34. NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function PMID: 15699051
35. CR16 and N-WASP are suggested to play important roles in spermatogenesis PMID: 17573773
36. although WASP serves a unique role for peripheral T cell function, T cell development depends on the combined activity of WASP and N-WASP PMID: 17878299
37. Thus, our data suggest that N-WASP deficiency leads to reduced adhesion to fibronectin and increased cell motility. PMID: 17963692
38. amphiphysin interaction with N-WASP regulates actin assembly PMID: 19759398
39. Study uncovers a strong reciprocal interdependence between Nck and PI(4,5)P(2) in promoting localized N-WASp-mediated actin polymerization in cells. PMID: 19917259

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KEGG: mmu:73178

STRING: 10090.ENSMUSP00000031695

UniGene: Mm.1574