Recombinant Mouse P2X purinoceptor 1 (P2rx1), partial

1. authors proposed a tentative intracellular signaling pathway of the acetylcholine-induced ciliary beat, in which the pannexin-1-purinergic P2X receptor unit may play a central role in ciliary beat regulation PMID: 29676177
2. Quite the reverse is seen in P2X1(-/-) mice, which had markedly lower cytokine levels and less coagulation activation compared to controls after exposure to uropathogenic Escherichia coli. PMID: 28428949
3. secretion of IL-22 in the regenerating liver is modulated by the ATP receptor, P2X1 PMID: 26853442
4. Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism. PMID: 25921923
5. This study reveals a major role for the P2X1 receptor in LPS-induced lethal endotoxemia through its critical involvement in neutrophil emigration from venules. PMID: 25480563
6. NTPDase1 controls male fertility via the regulation of P2X1 activation. PMID: 25160621
7. The presence of the P2X1 receptor on both polymorphonuclear neutrophils and platelets is important for fibrin generation and thrombus formation in vivo. PMID: 25150292
8. Male contraception via simultaneous knockout of alpha1A-adrenoceptors and P2X1-purinoceptors in mice. PMID: 24297884
9. P2X(1) ion channels play a protective role in endotoxemia by negatively regulating systemic neutrophil activation, thereby limiting the oxidative response, coagulation, and organ damage. PMID: 22212928
10. loss of Dicer may impair the expression of miRNAs that are capable of targeting P2x mRNAs. PMID: 22796409
11. The activity of P2X2/3 receptors in nodose ganglion neurons is involved in the transmission of myocardial ischemic nociceptive signal. PMID: 20615761
12. The P2X receptor phenotype in megakaryocytes and (by inference) platelets is due to expression of homomeric P2X1 receptors. PMID: 11815371
13. P2X(1) receptor-deficient mice establish the native P2X receptor and a P2Y6-like receptor in arteries. PMID: 12435812
14. Data suggest that the P2X1 receptor contributes to the formation of platelet thrombi, particularly in arteries in which shear forces are high. PMID: 12913094
15. P2X1 receptors have a role in renal microvascular autoregulatory behavior PMID: 14679185
16. altered function of P2X receptors may be an important contributor to pathogenic Ca2+ entry in dystrophic mouse muscle and may have implications for the pathogenesis of muscular dystrophies PMID: 16581969
17. analysis of a novel interaction between platelet P2X1 and thrombin receptors, with P2X1 functioning to amplify aggregation responses at low levels of thrombin receptor stimulation PMID: 16634759
18. The data support the hypothesis that jCaTs represent Ca(2+) that enters smooth muscle cells through P2X(1) receptors activated by neurally released ATP and this Ca(2+) is involved in the initial rapid component of the sympathetic neurogenic contraction. PMID: 16920810
19. The absence of a correlation between DE and neuroeffector calcium transient amplitudes suggests that the NCT amplitude is a poor measure of quantal size. PMID: 17629625
20. Thus an increased SR Ca(2+) content, occurring in the absence of cAMP accumulation or L-type Ca(2+) channel activation, is the principal mechanism by which cardiac P2X receptor mediates a stimulatory effect on cardiac myocyte contractility. PMID: 17873021
21. Mouse peritoneal macrophages that are minimally activated demonstrate membrane currents in response to ATP and alpha beta meATP that have the predominate features of P2X1 receptors PMID: 17934511
22. analysis of ectodomain lysines and suramin block of P2X1 receptors PMID: 18765669
23. Activation of P2X1 ion channels by adenosine triphosphate (ATP) promotes neutrophil chemotaxis via Rho kinase-dependent actomyosin-mediated contraction at the cell rear. PMID: 19635923

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KEGG: mmu:18436

STRING: 10090.ENSMUSP00000021141

UniGene: Mm.25722